Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: The present invention refers to the use of HMP (a secondary metabolite obtained from Aspergillus fungi) as an agent that intensifies the mechanism of macrophage activation, leading to the death of L. (Leishmania) amazonensis, the etiologic agent of cutaneous leishmaniasis. The main mechanism of action of this agent is the activation of the microbicidal activity of host cells, through increased superoxide production, number of lysosomes, actin and microtubule filament polymerization and increased spreading, typical of activated cells. Additionally, HMP represents a molecule of easy acquisition, presents an efficient combat mechanism with no adverse reactions and capacity to inhibit the development of promastigotes and amastigotes forms. Finally, results suggest HMP to be a potential candidate for use against cutaneous leishmaniasis at a minimal concentration of 50 ?g/mL.

Abstract: A universal fuel injection system for liquid and gaseous fuels and mixes thereof the universal fuel injection system having a universal fuel injection module interposed between a liquid fuel injector nozzle the universal fuel injection module having a spring-biased gaseous fuel valve connected to a pressurized gaseous fuel source and to a conical poppet mixing valve in the fuel injector nozzle where liquid fuel from the liquid fuel actuator unit and gaseous fuel selectively admitted through the spring-biased gaseous fuel valve mix for discharge through a fuel nozzle discharge orifice.

Abstract: A high pressure internal combustion engine having a triple thermal cycle system for improved cooling and combustion utilizing an annular volume surrounding the cylinder having a connecting passage to the combustion chamber allowing air to enter the volume on compression, and a water injection system for injecting water into the volume during initiation of combustion, the water spray changing to steam to drive the air into the combustion chamber during combustion, the air, steam and combustion gases mixing and improving the engine efficiency, the system being combinable with an injection system that conserves energy by pumping high pressure fluid only during the injection process.

Abstract: A universal fuel injection system for liquid and gaseous fuels and mixes thereof the universal fuel injection system having a universal fuel injection module interposed between a liquid fuel injector nozzle the universal fuel injection module having a spring-biased gaseous fuel valve connected to a pressurized gaseous fuel source and to a conical poppet mixing valve in the fuel injector nozzle where liquid fuel from the liquid fuel actuator unit and gaseous fuel selectively admitted through the spring-biased gaseous fuel valve mix for discharge through a fuel nozzle discharge orifice.

Abstract: A compressed gas dispensing station having a high pressure gas compressor with a cyclic control system for selective recirculation of cooled, ultra high pressure gas through the compression chamber after the end of the compression stroke for scavenging hot compressed gas from the compression chamber and providing a residual, partially-expanded replacement gas for the expansion stroke which is mixed with the incoming, new charge of gas for a cryogenic gas at the start of compression and a relatively low temperature gas at the end of compression for a single stage compressor.

Abstract: A fuel injection system for an engine having a combustion chamber, the fuel injection system in a preferred embodiment having a hydraulic actuator module with a hydraulic actuating fluid for activating a fuel injection piston with fluid in an actuating chamber of an injector defined in part by a large head, amplifying piston connected to the fuel injection piston the actuating fluid communicating with a hydraulic pulse pump driven by the pressure in the combustion chamber, the injector including a sub-module to provide a multi-pulse discharge to fuel and a discharge nozzle having an orifice with a poppet valve having a structure to provide a pulsed, conical, swirling spray of fuel.

Abstract: A power plant system particularly useful for hybrid vehicles driven by electric motors, the power plant system including a positive displacement engine with a bifurcated exhaust forming first and second exhaust passages for expansion gases, each passage being separately controlled by an independently operated engine exhaust valve, the first exhaust passage supplying expansion gases to a turbine connected to a compressor delivering compressed air to the engine and the second exhaust passage supplying expansion gases to a turbine connected to an electric generator, the power plant system having a system control module independently controlling each exhaust valve for optimum air compression for the load and speed of engine operation.

Abstract: A fuel injection system for an engine having a combustion chamber, the injection system having at least one fuel injector with a hydraulically operated actuator for amplifying the pressure of fuel injected from the injector into the combustion chamber, the hydraulic actuator communicating with a hydraulic pulse pump having a slide piston displaced by the pressure of compression and combustion gases within the combustion chamber, the fuel pressure having an amplified pressure profile paralleling the developed pressure profile of gases compressed and combusted in the combustion chamber, and in an alternate embodiment the pulse pump delivers high pressure hydraulic fluid to a common rail for use by multiple injectors and including a further embodiment where the high pressure fluid in the common rail is used as the motive fluid for actuating the engine combustion chamber valves.

Abstract: A high pressure gas compressor in one embodiment having an internal two staged compression with a compression chamber formed in part by a positive displacement, stepped piston and cylinder configuration, providing a first stage compression by an enlarged diameter segment of the piston and a second stage compression provided by a smaller diameter segment of the piston, and in another embodiment having an internal, single stage compression with a high compression ratio.

Abstract: A fuel injector system for a high speed, high pressure engine, the fuel injector system including a pressurized fuel supply, a fuel distributor with an electronically controlled and electronically monitored fuel metering mechanism and a fuel injector with an electronically monitored needle valve wherein the fuel system includes an electronic control module to receive signals from the positioning of the needle valve and the signals from the fuel metering mechanism for analysis and electronic regulation of the metering system to effect injection according to optimum operating conditions.

Abstract: A high pressure gas compressor having an internal two staged compression with a compression chamber formed in part by a positive displacement, stepped piston and cylinder configuration, providing a first stage compression by an enlarged diameter segment of the piston and a second stage compression provided by a smaller diameter segment of the piston. Temperature is maintained within design limits by the admission to the compression chamber of an expanded gas from a high pressure storage, which on adiabatic expansion of the admission gas reduces the temperature of the mixed charge for final compression at a resultant temperature that is within the design limits of the compressor unit.

Abstract: A fuel injection system for an engine having a combustion chamber, the injection system having at least one fuel injector with a hydraulically operated actuator for amplifying the pressure of fuel injected from the injector into the combustion chamber, the hydraulic actuator communicating with a hydraulic pulse pump having a slide piston displaced by the pressure of compression and combustion gases within the combustion chamber, the fuel pressure having an amplified pressure profile paralleling the developed pressure profile of gases compressed and combusted in the combustion chamber.

Abstract: A high pressure gas compressor in one embodiment having an internal two staged compression with a compression chamber formed in part by a positive displacement, stepped piston and cylinder configuration, providing a first stage compression by an enlarged diameter segment of the piston and a second stage compression provided by a smaller diameter segment of the piston, and in another embodiment having an internal, single stage compression with a high compression ratio.

Abstract: A universal combustion system for positive displacement thermal engines enabling use of different kinds and types of fuels the combustion system including a premix and precombustion module that is connected to the main combustion chamber of the engine for premixing air and fuel in a premix chamber in the module that is isolated from the main combustion chamber, the module having automatic control means coordinated with the compression cycle of the engine for premixing fuel and air in the premix chamber and releasing the mixture into the main combustion chamber at an opportune time in the engine cycle.

Abstract: A universal internal combustion engine that is electronically and reversibly convertible from four stroke operation to two stroke operation, the engine having intake and exhaust valves with an electro-hydraulic actuator system for actuating the valves in accordance with electronic control signals from an electronic control module, the electro-hydraulic actuator system having an electronic actuator for each valve coupled to a slide valve for discrete supply of a pressurized hydraulic fluid to a hydraulic piston for each valve, the electronic control module having a program for independent activation of each electronic actuator for select operation of each intake and exhaust valve at any time during the operating cycle.

Abstract: A thermal engine utilizing a positive displacement rotary expander and preferably a positive displacement rotary compressor in conjunction with an external substantially steady-state thermal source, such as a continuous fuel combustor, the external source heating a high pressure gas that is directed from the thermal source to the rotary expander wherein the gases expand driving a rotor in the positive displacement rotary engine before discharge. An additional embodiment of the thermal engine includes a modified epitrochoidal chamber configuration for the compression cycle and the expansion cycle to utilize the total internal volume for each compression pulse and expansion pulse for obtaining improved thermal efficiency in a manner similar to super long stroke reciprocal piston engines.

Abstract: An internal combustion unit having a cylinder with at least one power piston with thermal means for reciprocating the power piston in the cylinder, the power piston and cylinder defining a combustion chamber, and a generator unit having a linear inductor piston coupled to the power piston for reciprocation together with the power piston and a stationary coil stator constructed in the configuration of an annulus, wherein the inductor piston reciprocates in the annulus of the coil stator and electrical current is generated in the stator.

Abstract: A high pressure fuel injector having high pressure fuel admission passages and low pressure fuel return passages with a needle valve hydraulically operated by high pressure fuel from the high pressure fuel admission passage by a distributor valve which selectively directs a hydraulic pressure fuel against one side or the other of a piston body forming part of the needle valve whereby the needle valve is urged to a position closing discharge orifices or position opening discharge orifices the distributor valve being controlled by an electronic actuator.

Abstract: A rotary air compressor with a housing forming an epitrochoidal chamber in which a multilobed rotor with a ring gear eccentrically rotates on an internal central gear in the housing, the rotor dividing the chamber into multiple subchambers of changing volume as the rotor rotates, the chamber having intake ports of variable size opening to change the quantity of gas that is compressible and outlet ports having spring biased plunger valves to prevent flow of discharged compressed air back into the compressor.