Abstract: Elastogenic nanoparticles including a polymeric core having a surface that is functionalized with a cationic amphiphilic compound, and comprising an active agent having pro-elastogenic and/or anti-proteolytic activity, are described herein. The elastogenic nanoparticles can be used in method of stimulating elastogenesis in a subject by administering to the subject a therapeutically effective amount of elastogenic nanoparticles.

Abstract: Fibrinolytic nanoparticles including a polymeric core having a surface that is functionalized with a cationic amphiphilic compound, and a fibrinolytic agent dispersed within the core, are described herein. The fibrinolytic nanoparticles can be used in method of dissolving a blood clot in a subject by administering to the subject a therapeutically effective amount of fibrinolytic nanoparticles.

Abstract: Fibrinolytic nanoparticles including a polymeric core having a surface that is functionalized with a cationic amphiphilic compound, and a fibrinolytic agent dispersed within the core, are described herein. The fibrinolytic nanoparticles can be used in method of dissolving a blood clot in a subject by administering to the subject a therapeutically effective amount of fibrinolytic nanoparticles.

Abstract: Fibrinolytic nanoparticles including a polymeric core having a surface that is functionalized with a cationic amphiphilic compound, and a fibrinolytic agent dispersed within the core, are described herein. The fibrinolytic nanoparticles can be used in method of dissolving a blood clot in a subject by administering to the subject a therapeutically effective amount of fibrinolytic nanoparticles.

Abstract: Elastogenic nanoparticles including a polymeric core having a surface that is functionalized with a cationic amphiphilic compound, and comprising an active agent having pro-elastogenic and/or anti-proteolytic activity, are described herein. The elastogenic nanoparticles can be used in method of stimulating elastogenesis in a subject by administering to the subject a therapeutically effective amount of elastogenic nanoparticles.

Abstract: Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers, optionally in conjunction with growth factors and/or a source of copper ions. The elastogenic cues can up-regulate elastin matrix synthesis and by vascular smooth muscle cells. In addition to encouraging synthesis of elastin in a cellular matrix and organization into elastic fibers, the elastogenic cues can also stabilize the formed ECM matrix through suppression of elastin-laminin receptor (ELR). In addition, the elastogenic cues can inhibit cell hyper-proliferation (e.g., hyperplasia) common in inflammatory vascular disease.

Abstract: The improved bandwidth provisioning solution of the present invention enables the provision of bandwidth on demand by dynamically establishing and terminating one or more dynamic virtual circuits (SVCs) (137) to supplement a subscriber's default broadband connection. The improved bandwidth provisioning solution includes a client-side application (107) residing on the subscriber's data processing system (105) and a connection-management application (142) residing on a proxy signaling server (140). The client-side application (107) transmits a subscriber's request for a bandwidth-on-demand session to the connection-management application (142), which communicates with an asynchronous transfer mode (ATM) edge device (120) using User Network Interface (UNI) signaling to initiate the one or more VCs (137). When the subscriber no longer desires the additional bandwidth, the supplemental VCs (137) may be terminated.

Abstract: The improved bandwidth provisioning solution of the present invention enables the provision of bandwidth on demand by dynamically establishing and terminating one or more dynamic virtual circuits (SVCs) (137) to supplement a subscriber's default broadband connection. The improved bandwidth provisioning solution includes a client-side application (107) residing on the subscriber's data processing system (105) and a connection-management application (142) residing on a proxy signaling server (140). The client-side application (107) transmits a subscriber's request for a bandwidth-on-demand session to the connection-management application (142), which communicates with an asynchronous transfer mode (ATM) edge device (120) using User Network Interface (UNI) signaling to initiate the one or more VCs (137). When the subscriber no longer desires the additional bandwidth, the supplemental VCs (137) may be terminated.