Patents by Inventor Ananth Srinivasan
Ananth Srinivasan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220370648Abstract: Embodiments of the present disclosure provide compositions comprising compounds useful to make radiotracers for positron emission tomography imaging, as well as methods for making and using these compositions.Type: ApplicationFiled: May 7, 2021Publication date: November 24, 2022Applicant: CellSight Technologies Inc.Inventors: Jelena Levi, Ananth Srinivasan, Alexander Hoepping, Rene Smits
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Patent number: 10881749Abstract: Embodiments of the present disclosure provide for labeled probes such as labeled maltoside probes and labeled maltotriose probes, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, and the like.Type: GrantFiled: April 12, 2016Date of Patent: January 5, 2021Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mohammad Namavari, Gayatri Gowrishankar, Sanjiv S. Gambhir, Ananth Srinivasan
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Patent number: 10675366Abstract: The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [18F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.Type: GrantFiled: August 11, 2017Date of Patent: June 9, 2020Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Corrine Gaye Beinat, Israt Shamima Alam, Michelle L. James, Sanjiv S. Gambhir, Ananth Srinivasan
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Publication number: 20180043040Abstract: The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [18F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.Type: ApplicationFiled: August 11, 2017Publication date: February 15, 2018Inventors: Corinne Gaye Beinat, Israt Shamima Alam, Michelle L. James, Sanjiv S. Gambhir, Ananth Srinivasan
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Publication number: 20160303259Abstract: Embodiments of the present disclosure provide for labeled probes such as labeled maltoside probes and labeled maltotriose probes, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, and the like.Type: ApplicationFiled: April 12, 2016Publication date: October 20, 2016Inventors: Mohammad Namavari, Gayatri Gowrishankar, Sanjiv S. Gambhir, Ananth Srinivasan
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Patent number: 8557776Abstract: The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.Type: GrantFiled: September 7, 2007Date of Patent: October 15, 2013Assignee: Bayer Pharma AGInventors: Lutz Lehmann, Ananth Srinivasan, Thomas Brumby, Detlef Suelzle, Timo Stellfeld, Keith Graham, Mylene Tania Karramkam, Simon Ametamey
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Publication number: 20120241171Abstract: A hanger assembly provided for multiple hanging opportunities. If liner is being run and the primary hanger doesn't work then a backup hanger is available to set near the nonfunctional primary hanger. In drilling with casing applications when there is a steering equipment malfunction or an MWD breakdown or bit wear requiring the BHA to be pulled, the liner can be hung where it is and the BHA pulled. Upon running back in with the BHA on a running tool the initial hanger can be released and the running tool configured to only set a different hanger when the total depth is reached in drilling with the liner. The running tool is then retrieved and the completion can go on.Type: ApplicationFiled: March 24, 2011Publication date: September 27, 2012Applicant: BAKER HUGHES INCORPORATEDInventors: Ananth Srinivasan, Alex D. Harris, Todd J. Talbot
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Publication number: 20110137063Abstract: The present invention relates to novel perfluorinated precursors for the production of F-18 labeled radiotracers for Positron Emission Tomography (PET) and processes for radiolabeling and purification using these precursors. The invention also comprises radiopharmaceutical kits using these precursors and processes.Type: ApplicationFiled: June 24, 2009Publication date: June 9, 2011Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Ananth Srinivasan, Mathias Berndt, Keith Graham, Matthias Friebe, Heribert Schmitt-Willich
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Publication number: 20110112293Abstract: The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and lime-saving way to purity the desired product S-X from non-reacted precursors S-L-M and by-products L-M.Type: ApplicationFiled: April 9, 2009Publication date: May 12, 2011Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: John Cyr, Ananth Srinivasan, Mathias Berndt, Keith Graham, Dae Yoon Chi, Byoung Se Lee, So Young Chu, Song-Yi Lim, Sang Ju Lee, Jin-Sook Ryu, Seung Jun Oh
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Publication number: 20090317326Abstract: The present invention relates to radiolabelled substitute benzene compounds for diagnostic imaging. The present invention provides methods for preparation of such compounds, in particular, preparation of novel compounds which serve as precursors for 18F-labeling, and the use of thus 18F-labeled compounds for diagnostic imaging.Type: ApplicationFiled: September 7, 2007Publication date: December 24, 2009Inventors: Ananth Srinivasan, Timo Stellfeld
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Publication number: 20090035215Abstract: The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characerized by Formula II, wherein the moieties F, R1, R2, B1,2, Y1,2, Z1,2 and E have the meaning as defined in the specification and claims.Type: ApplicationFiled: September 7, 2007Publication date: February 5, 2009Inventors: Ananth Srinivasan, Ulrich Klar, Lutz Lehmann, Ulrike Voigtmann, Timo Stellfeld, Aileen Hohne, Linjing Mu, Simon Ametamey
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Publication number: 20090022664Abstract: The present invention relates to novel compounds suitable for or already radiolabelled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging.Type: ApplicationFiled: September 7, 2007Publication date: January 22, 2009Inventors: Ananth Srinivasan, Thomas Brumby, Timo Stellfeld, Keith Graham, Ulrike Voigtmann, Jessica Becaud, Linjing Mu
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Publication number: 20080292548Abstract: The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.Type: ApplicationFiled: September 7, 2007Publication date: November 27, 2008Inventors: Lutz Lehmann, Ananth Srinivasan, Thomas Brumby, Detlef Suelzle, Timo Stellfeld, Keith Graham, Mylene Karramkam, Simon Ametamey
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Publication number: 20080207523Abstract: The object of the present invention is solved by compositions of peptide linkers and their use for synthesis and annealing of aptamer oligonucleotides in form of dimers. The present invention in particularly provides said compositions for the use as a diagnostic and/or therapeutic agent. In another preferred embodiment the present invention relates to a kit for preparing a radiopharmaceutical preparation, said kit comprising a vial comprising a quantity of the compound according to the invention. A further preferred embodiment of the present invention relates to methods of producing said compounds, comprising synthesis of said compound in an automated peptide synthesizer. In another preferred embodiment the present invention concerns the use of said compounds according to the present invention for the manufacture of a medicament, preferably for diagnosis or therapy of proliferative diseases.Type: ApplicationFiled: September 7, 2007Publication date: August 28, 2008Inventors: Matthias Friebe, Andrew Stephens, Ananth Srinivasan, Maren Hecht
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Publication number: 20080170993Abstract: The present invention relates to nucleoside analogues and more particularly to labeled nucleoside analogues. It has been found new thymidine analogues can be stably labeled with a detectable label moiety. Further the present invention relates to methods of making above compounds and use of such compounds for diagnostic imaging of tumor cells and/or treatment of proliferative diseases. In addition, the present invention relates to the preparation and use of positron emitting compounds for positron emission tomography (PET). A kit is also disclosed.Type: ApplicationFiled: October 24, 2007Publication date: July 17, 2008Inventors: Ananth SRINIVASAN, Ulrike Voigtmann, Mathias Berndt, Keith Grahan, Sabine Zitzmann, Lutz Lehmann, Ansgar Fitzner
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Publication number: 20070066516Abstract: The present invention concerns compounds comprising novel cyclized peptides with increased selectivity towards binding to the somatostatin receptor 5 (SSTR5) its production and use in the diagnosis and treatment of somatostatin-responsive diseases or diseases characterized by up-regulation of somatostatin receptors, in particular proliferative diseases.Type: ApplicationFiled: April 27, 2006Publication date: March 22, 2007Inventors: Ananth Srinivasan, Leonard Luyt
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Publication number: 20070021349Abstract: The present invention concerns novel orthogonally protected amino acids, there production and use for the synthesis of binding compounds usable in the diagnosis and treatment of proliferative diseases, in particular tumor diseases.Type: ApplicationFiled: April 25, 2006Publication date: January 25, 2007Inventors: Ananth Srinivasan, Leonard Luyt