Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.

Abstract: A one-way wrench having a catching device with two catches and a catch holder and having differential teeth is provided and characterized in that: the catching device is disposed in a catching chamber laterally disposed beside a driving hole of the one-way wrench; the catching device has two catches, two position-restoring elements, and a catch holder; the catch holder pushes the two catches simultaneously, such that a single stable base structure pushes the two catches simultaneously; and starting ends of tooth portions of the two catches are dentate to different extents, so as to effectuate a small transmission-oriented tooth-changing angle, achieve stable control, as well as cut production and maintenance costs.

Abstract: A one-way wrench having a catching device with two catches and a catch holder and having differential teeth is provided and characterized in that: the catching device is disposed in a catching chamber laterally disposed beside a driving hole of the one-way wrench; the catching device has two catches, two position-restoring elements, and a catch holder; the catch holder pushes the two catches simultaneously, such that a single stable base structure pushes the two catches simultaneously; and starting ends of tooth portions of the two catches are dentate to different extents, so as to effectuate a small transmission-oriented tooth-changing angle, achieve stable control, as well as cut production and maintenance costs.

Abstract: A multiple size socket is provided with a base, a socket body, and a positioning unit. The base is provided with a connecting portion, two pivot portions and a pivot hole formed in each of the pivot portions. The socket body is pivoted between the two pivot portions and includes a plurality of engaging cavities and an inserting hole aligned with the two pivot holes. The positioning unit is inserted in the two pivot holes and the inserting hole. The engaging cavities are different in size and shape from one another, so that the socket is capable of driving different sized fasteners.

Abstract: A multiple size socket is provided with a base, a socket body, and a positioning unit. The base is provided with a connecting portion, two pivot portions and a pivot hole formed in each of the pivot portions. The socket body is pivoted between the two pivot portions and includes a plurality of engaging cavities and an inserting hole aligned with the two pivot holes. The positioning unit is inserted in the two pivot holes and the inserting hole. The engaging cavities are different in size and shape from one another, so that the socket is capable of driving different sized fasteners.

Abstract: A ratchet wrench adjustable in clamping size is provided with a body, a ratchet wheel, an adjustment member, two engaging members and a spring. The body includes a head portion, a handle and a switch member. The two engaging members are oppositely located on the ratchet wheel and the adjustment member and each include an engaging portion, a neck portion connected to the engaging portion and located in the ratchet wheel, and an upper portion connected to the neck portion and located in the adjustment cavity of the adjustment member. By such arrangements, rotating the rotating portion of the adjustment member adjusts relative positions of the upper portions of the two engaging members in the adjustment cavity of the adjustment member, and makes the neck portions of the engaging members to move along the guide slot so as to change a distance between the two engaging portions.

Abstract: An anti-abrasion open end quick turn wrench is suitable for rotating a fastener with a head portion and includes: a body and an assistant engaging member. When the head portion of the fastener is completely engaged in the engaging slot, the wrench is provided with anti-abrasion concaves to provide enough room to prevent the open end wrench from interfering with the angles of the head portion of the fastener, and consequently preventing abrasion of the head portion of the fastener. Meanwhile, at least three lateral surfaces of the head portion of the fastener will be clamped by the wrench, when one or two of the clamped four lateral surfaces of the fastener is damaged or worn out, the fastener still has at least two intact lateral surfaces clamped by the open end quick turn wrench, so it can still be rotated by the wrench.

Abstract: A ratchet wrench adjustable in clamping size is provided with a body, a ratchet wheel, an adjustment member, two engaging members and a spring. The body includes a head portion, a handle and a switch member. The two engaging members are oppositely located on the ratchet wheel and the adjustment member and each include an engaging portion, a neck portion connected to the engaging portion and located in the ratchet wheel, and an upper portion connected to the neck portion and located in the adjustment cavity of the adjustment member. By such arrangements, rotating the rotating portion of the adjustment member adjusts relative positions of the upper portions of the two engaging members in the adjustment cavity of the adjustment member, and makes the neck portions of the engaging members to move along the guide slot so as to change a distance between the two engaging portions.

Abstract: An anti-abrasion open end quick turn wrench is suitable for rotating a fastener with a head portion and includes: a body and an assistant engaging member. When the head portion of the fastener is completely engaged in the engaging slot, the wrench is provided with anti-abrasion concaves to provide enough room to prevent the open end wrench from interfering with the angles of the head portion of the fastener, and consequently preventing abrasion of the head portion of the fastener. Meanwhile, at least three lateral surfaces of the head portion of the fastener will be clamped by the wrench, when one or two of the clamped four lateral surfaces of the fastener is damaged or worn out, the fastener still has at least two intact lateral surfaces clamped by the open end quick turn wrench, so it can still be rotated by the wrench.

Abstract: A locking structure for the box body is provided with a box body, a handle, and a cover. The handle is a rotatable structure which can support the box body to make the box body stand in an inclined manner, so as to allow the user to have a full clear view of the hand tools inside the tool box. On top of that, the tool box offers an antitheft feature, when the tool box is closed, the cover cannot be opened and removed from the box body unless the locking ends of the retainers are destroyed. Therefore, the hand tools cannot be taken out of the tool box without permission.

Abstract: A covering device for a drain includes a first cover and a second cover. The first cover defines a plurality of openings. The second cover defines a plurality of openings corresponding to the openings of the first cover. The second cover is rotationally connected to the first cover. In a position, the openings of the second cover are aligned with the openings of the first cover in order to open the drain. In another position, the first cover blocks the openings of the second cover while the second cover blocks the openings of the first cover in order to close the drain.

Abstract: A wrench suspension rack assembly has a suspension base including two spaced protrusions on a side thereof and a wrench support rack for holding a plurality of tools. The wrench support rack includes a first side and a second side. Two spaced through-holes extend from the first side to the second side of the wrench support rack. The protrusions of the suspension base are respectively extended through the through-holes to thereby allow removable attachment of the wrench support rack to the suspension base.

Abstract: A close end wrench includes a shank and a close end in which an elongated hole is defined therethrough. A symmetric axis “S” passes through a middle position of the close end and intersects at a first point S1 and a second point S2 of an inner periphery of the elongated hole. A first inner surface and a second inner surface in the inner periphery of the elongated hole are formed and separated by the symmetric axis “S”. A first recess surface defined in the first inner surface and starts from the first point S1. A convex is connected to the first recess surface and a first protrusion surface is connected to the convex. A second recess surface is connected to the first protrusion surface and a second protrusion surface is connected to the second recess surface. The second protrusion surface is ended at the second point S2. The second inner surface is shaped as a mirror image of the first inner surface about the symmetric axis “S”.

Abstract: A wrench suspension rack assembly comprises a suspension base including two spaced protrusions on a side thereof and a wrench support rack for holding a plurality of tools. The wrench support rack includes a first side and a second side. Two spaced through-holes extend from the first side to the second side of the wrench support rack. The protrusions of the suspension base are respectively extended through the through-holes to thereby allow removable attachment of the wrench support rack to the suspension base.

Abstract: A wrench support rack assembly includes a support rack having a base plate having a first side and a second side, a side plate mounted on the first side of the base plate, a top plate mounted on the side plate and arranged in parallel with the base plate, and a plurality of spaced support plates each mounted on the side plate, thereby defining a plurality of receiving chambers between the top plate and the base plate each having a closed wall and an open wall. A retaining piece is mounted on the support plates of the support rack for sealing the open wall of each of the receiving chambers and has a first end pivotally mounted on the second side of the base plate and a second end detachably secured on the top plate.