Abstract: Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.

Abstract: Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.

Abstract: Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.

Abstract: Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.

Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.

Abstract: Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.

Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.

Abstract: The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.

Abstract: The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.

Abstract: The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.

Abstract: Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.

Abstract: The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.

Abstract: The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.

Abstract: The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.

Abstract: An improved multiplex ligation-dependent amplification method is disclosed for detecting the presence of specific methylated sites in a single stranded target nucleic acid, while simultaneously, the quantification of the target nucleic acid sequence can be performed, using a plurality of probe sets of at least two probes, each of which includes a target specific region and non-complementary region containing a primer binding site. At least one of the probes further includes the sequence of one of the strands of a double stranded recognition site of a methylation sensitive restriction enzyme. The probes belonging to the same set are ligated together when hybridised to the target nucleic acid sequence, the hybrid is subjected to digestion by the methylation sensitive restriction enzyme, resulting in non-methylated recognition sites being cleaved. The probes of the uncleaved (methylated) hybrid are subsequently amplified by a suitable primer set.

Abstract: An electric switching device for alternating current comprises two branches (2, 3) connected in parallel in a current path and having each at least two contact members (4–7) connected in series. A semiconductor device (8) is adapted to interconnect the midpoints between the two contact members of each branch. When opening the current path a first contact member (5) of one, first branch located before said midpoint as seen in the current direction existing is controlled to open and a second contact member (6) of the second branch located after the midpoint as seen in the current direction is controlled to open for transferring the current to a temporary current path through the semiconductor device. The current path through the switching device is then broken when the semiconductor device is in a blocking state by opening a contact member (4, 7) of the switching device arranged in the temporary current path.

Abstract: The magnetic circuit of a generator in a hydro-generator plant is arranged to directly supply a high supply voltage of 20-800 kV, preferably higher than 36 kV. The generator is provided with solid insulation and its winding includes a cable (6) comprising one or more current-carrying conductors (31) with a number of strands (36) surrounded by at least one outer and one inner semiconducting layer (34, 32) and intermediate insulating layers (33). The outer semiconducting layer (34) is at earth potential. The stator winding may be produced with full or fractional slot winding, the phases of the winding being Y-connected. The Y-point may be insulated and protected from over-voltage by means of surge arresters, or else the Y-point may be earthed via a suppression filter. The invention also relates to a hydro-generator plant, a generator included in the plant and a procedure for building such a plant.

Abstract: An electric high voltage AC machine intended to be directly connected to a distribution or transmission network (16) comprises at least one winding. This winding comprises at least one current-carrying conductor, a first layer having semiconducting properties provided around said conductor, a solid insulating layer provided around said first layer, and a second layer having semiconducting properties provided around said insulating layer. In addition grounding means (18, 24, 26, 28) are provided to connect at least one point of said winding to ground.

Abstract: A synchronous machine for power and/or voltage control comprises a stator with a stator winding and a rotor with a field winding. The stator winding comprises a high-voltage cable with solid insulation. A rotor has a thermally based rotor current limit intersecting with a thermally based stator current limit in a capability graph at a power factor considerably below the rated power factor or has the thermally based rotor current limit above the thermally based stator current limit. In the capability graph. Means are provided for limiting the currents in order to avoid thermal damage. In a method for power and/or voltage control of such a synchronous machine, the machine operates with the stator current exceeding the thermally based stator current limit for a certain time period less than the maxim an permissible time limit, whereafter the overload is reduced by reduction of either the active power or the field current or a combination of both.

Abstract: A high power static electromagnetic device with variable inductance has a magnetic circuit with a flux bearing region. A main winding and at least one control winding surrounds the portions of the flux bearing region. A control device is coupled to the control winding for varying the distribution of flux. The winding is formed of a magnetically permeable, field-confining insulating cable.