Abstract: A method and system for calibrating molecular arrays to a reference molecular array, and for subsequently calibrating the molecular arrays to maintain a constant signal-intensity-to-label-concentration ratio. In the first step of the two-step calibration method, a reference array coated with the fluorophore or chromophore used to label probe molecules is employed, while in the second step of the two-step method, a reference array coated with a stable dye is employed.

Abstract: A method and system for calibrating molecular arrays to a reference molecular array, and for subsequently calibrating the molecular arrays to maintain a constant signal-intensity-to-label-concentration ratio. In the first step of the two-step calibration method, a reference array coated with the fluorophore or chromophore used to label probe molecules is employed, while in the second step of the two-step method, a reference array coated with a stable dye is employed.

Abstract: A method of bonding a microarray to a package uses optional surface treatments on the microarray and on the package to enhance the adhesion of the microarray to the package using an adhesive. The adhesive bonds to the microarray and the package with sufficient bond strength and flexibility to withstand the stress caused by different expansion rates during exposure to temperature extremes. A method of attaching the microarray to the package uses a plurality of adhesives to provide the bond strength and flexibility. A packaged microarray apparatus comprises a microarray of biological features, a package, and an adhesive bond between the microarray and the package. The apparatus may have surface treatment and/or the adhesive bond may comprise a plurality of adhesives.