Abstract: The system includes: an assortment (10) of sensors (10a, 10b, 10c), wherein the working electrode (14a) of each sensor is covered with a specific reagent of a given proteolytic enzyme, including a substrate capable of releasing leaving groups (LG) via the action of the enzyme; a measuring apparatus (20) having an electronic circuit imposing a current, whose intensity or voltage may or may not be variable, between the electrodes, and for receiving in return a signal representative of the release of the LG; and an electronic apparatus (30) for processing the transmitted signal and displaying, on a display screen (32), an indication representative of the release of the LG as a function of time. The system may be used to determine, in a plasma or whole blood sample, factors responsible for a coagulation anomaly.

Abstract: The system includes an assortment (10) of sensors (10a, 10b, 10c), the working electrode (14a) of each sensor being covered with a specific reagent of a given proteolytic enzyme, including a substrate capable of releasing leaving groups (LG) via the action of said enzyme, a measuring apparatus (20) having an electronic circuit imposing a current, whose intensity or voltage may or may not be variable, between the electrodes, and for receiving in return a signal representative of the release of the LG, and an electronic apparatus (30) for processing the transmitted signal and displaying, on a display screen (32), an indication representative of the release of the LG as a function of time. Application to determination, in a plasma or whole blood sample, of the factors responsible for a coagulation anomaly.

Abstract: Electrochemical system for measuring a value representing the coagulation time of a drop of whole blood including: an electrochemical sensor in the shape of a strip of small dimensions bearing at least a reference electrode and a working electrode on which a specific reagent is immobilized, including at least one chemical substrate one terminal link of which can be cut off by the thrombin enzyme to give charged groups (LG), and a measuring apparatus intended to receive said sensor allowing a given voltage or current to be imposed across the electrodes of the sensor, the electric signal resulting from the migration of the charged groups to be processed, said signal to be correlated with a value representing the coagulation time, and said value to be displayed on a display panel. The specific reagent preferably includes an oligopeptidic derivative as a substrate, a thromboplastin and a buffer medium.