Abstract: A compound of general formula I and pharmaceutical compositions, kits, methods of making, and methods for treating cancer using the same.

Abstract: Disclosed implementations relate to using mutual constraint satisfaction to sample from different stochastic processes and identify coherent inferences across domains. In some implementations, a first domain representation of a semantic concept may be used to conditionally sample a first set of candidate second domain representations of the semantic concept from a first stochastic process. Based on second domain representation(s) of the first set, candidate third domain representations of the semantic concept may be conditionally sampled from a second stochastic process. Based on candidate third domain representation(s), a second set of candidate second domain representations of the semantic concept may be conditionally sampled from a third stochastic process. Pairs of candidate second domain representations sampled across the first and second sets may be evaluated. Based on the evaluation, second domain representation(s) of the semantic concept are selected, e.g., as input for a downstream computer process.

Abstract: Drug conjugates having formula [D-(X)b-(AA)w-(T)g-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, (I) wherein D is covalently attached via a hydroxy or amine group to (X)b if any, or (AA)w if any, or to (T)g if any, or (L); that are useful in the treatment of cancer.

Abstract: A workload management system includes a workload management tool configured to generate a workload context associated with a workload generated based on interactions of a user with workload initiation controls presented within a user interface (UI) of a client application. The workload context includes instructions for transmitting the workload context from a main browser session to a first background browser session; executing the workload within the first background session; and for configuring a first event handler within the main session to wait for a first event generated within the first background session in association with execution of the workload and, in response to receipt of the first event, transmit the client application an instruction to present workload status information in the user interface.

Abstract: In some aspects, a computing system can determine a set of attributes based on analyzing input data using attribute templates written in a production-ready programming language. The computing system can generate attribute definitions for the set of attributes using the attribute templates and deploy the attribute definitions for the set of attributes to a production environment of a software program. The software program is written in a programming language compatible with the production-ready programming language. The computing system can monitor the performance of the set of attributes in the production environment of the software program and cause the attribute definitions of the plurality of attributes to be modified based on the monitoring.

Abstract: An exemplary robotic system includes a plurality of controllable joints and a controller. An exemplary control method provides for controlling the controllable joints by the controller. The control method provides for determining a configuration space for the robotic system and determining a reference movement path within the configuration space. The control method then provides for assigning a plurality of streamlines in the configuration space to yield a flow field based on the reference movement path. The control method then provides for measuring actual velocity vectors of the robotic system in the configuration space. The control method then provides for determining an error velocity vector based on a difference between the actual velocity vector and the desired velocity vector given by the flow field corresponding to the current robot configuration.

Abstract: The disclosure herein describes analyzing queries and dynamically modifying those queries based on the analysis. An indication that a query is to be executed by a first process is detected. It is determined that an analysis results data store does not include an active analysis result for the query using a query identifier of the query and, as a result, a modified instance of the query is generated using a modification pattern. The query and the modified instance of the query are analyzed based on a performance metric using a second process that is independent of the first process. An active analysis result of the query is recorded based on the analysis, wherein the analysis result indicates whether future executions of the query should be modified using the modification pattern. Further, in some examples, analysis results expire, such that associated queries are reanalyzed to generate active analysis results periodically.

Abstract: In some aspects, a computing system can determine a set of attributes based on analyzing input data using attribute templates written in a production-ready programming language. The computing system can generate attribute definitions for the set of attributes using the attribute templates and deploy the attribute definitions for the set of attributes to a production environment of a software program. The software program is written in a programming language compatible with the production-ready programming language. The computing system can monitor the performance of the set of attributes in the production environment of the software program and cause the attribute definitions of the plurality of attributes to be modified based on the monitoring.

Abstract: In some aspects, a computing system can determine a set of attributes based on analyzing input data using attribute templates written in a production-ready programming language. The computing system can generate attribute definitions for the set of attributes using the attribute templates and deploy the attribute definitions for the set of attributes to a production environment of a software program. The software program is written in a programming language compatible with the production-ready programming language. The computing system can monitor the performance of the set of attributes in the production environment of the software program and cause the attribute definitions of the plurality of attributes to be modified based on the monitoring.

Abstract: A method for improving a fluid dynamic profile and fouling properties of a marine vessel with a welding seam which forms a cap protruding above a surface being under the waterline of a vessel. The method comprising amending the welding seam by applying a fairing to the underwater surface, e.g. by use of filler. A vessel with a fairing, and a coating system for a vessel and including a fairing.

Abstract: The present application describes novel antifouling coating compositions comprising carbon-based hydrolysable polymers of ethylenically unsaturated monomers of which some include cyclic carbonates or cyclic ethers, e.g. (2,2-dimethyl-1,3-dioxolan-4-yl)methyl (meth)acrylate (IPGA/IPGMA), isopropylidene glycerol ethoxylated acrylate (iPGEOA), isopropylidene glycerol ethoxylated methacrylate (iPGEOMA) and (2-oxo-1,3-dioxolan-4-yl)methyl (meth)acrylate (GCA/GCMA), and their use in antifouling coating compositions. Novel polymers are also described.

Abstract: In some aspects, a computing system can determine a set of attributes based on analyzing input data using attribute templates written in a production-ready programming language. The computing system can generate attribute definitions for the set of attributes using the attribute templates and deploy the attribute definitions for the set of attributes to a production environment of a software program. The software program is written in a programming language compatible with the production-ready programming language. The computing system can monitor the performance of the set of attributes in the production environment of the software program and cause the attribute definitions of the plurality of attributes to be modified based on the monitoring.

Abstract: An exemplary robotic system includes a plurality of controllable joints and a controller. An exemplary control method provides for controlling the controllable joints by the controller. The control method provides for determining a configuration space for the robotic system and determining a reference movement path within the configuration space. The control method then provides for assigning a plurality of streamlines in the configuration space to yield a flow field based on the reference movement path. The control method then provides for measuring actual velocity vectors of the robotic system in the configuration space. The control method then provides for determining an error velocity vector based on a difference between the actual velocity vector and the desired velocity vector given by the flow field corresponding to the current robot configuration.

Abstract: A computer-implemented method comprises analyzing an advertisement presented to a user during a first time period to identify a plurality of ingredients; and analyzing documents related to a medical condition of the user to determine a respective first relevance rank for each ingredient. The method further comprises selecting a subset of the ingredients having a highest number of occurrences based on the respective first relevance rank for each of the ingredients; performing sentiment analysis of the documents for the selected subset; determining a respective second relevance rank for each of the ingredients in the selected subset based on the sentiment analysis; and computing a product risk score based on the respective second relevance rank for each of the ingredients in the subset. The method further comprises modifying a display on a device associated with the user such that the display indicates the product risk score during the first time period.

Abstract: A method for improving a fluid dynamic profile and fouling properties of a marine vessel with a welding seam which forms a cap protruding above a surface being under the waterline of a vessel. The method comprising amending the welding seam by applying a fairing to the underwater surface, e.g. by use of filler. A vessel with a fairing, and a coating system for a vessel and including a fairing.

Abstract: The present application describes novel antifouling coating compositions comprising carbon-based hydrolysable polymers of ethylenically unsaturated monomers of which some include cyclic carbonates or cyclic ethers, e.g. (2,2-dimethyl-1,3-dioxolan-4-yl)methyl (meth)acrylate (IPGA/IPGMA), isopropylidene glycerol ethoxylated acrylate (iPGEOA), isopropylidene glycerol N ethoxylated methacrylate (iPGEOMA) and (2-oxo-1,3-dioxolan-4-yl)methyl (meth)acrylate (GCA/GCMA), and their use in antifouling coating compositions. Novel polymers are also described.

Abstract: A computer-implemented method comprises analyzing an advertisement presented to a user during a first time period to identify a plurality of ingredients; and analyzing documents related to a medical condition of the user to determine a respective first relevance rank for each ingredient. The method further comprises selecting a subset of the ingredients having a highest number of occurrences based on the respective first relevance rank for each of the ingredients; performing sentiment analysis of the documents for the selected subset; determining a respective second relevance rank for each of the ingredients in the selected subset based on the sentiment analysis; and computing a product risk score based on the respective second relevance rank for each of the ingredients in the subset. The method further comprises modifying a display on a device associated with the user such that the display indicates the product risk score during the first time period.

Abstract: An assay device including a loading zone for a sample that may contain an analyte, an activator in communication with the loading zone from which at least one activator is displaced by presence of the analyte, an amplifier in an inactive state in communication with the activator that becomes activated in the presence of the activator, a biomatrix barrier in communication with the activated amplifier that is degraded or modified by the activated amplifier, and an indicator responsive to the degradation or modification of the biomatrix barrier, which in turn reflects a concentration of the analyte in the sample loaded on the device. The selection of analyte or displacement of the activator by presence of the analyte may occur off-platform and/or may rely on use of non-covalent interactions. The activator may include an enzyme or other reagent that activates the amplifier. Also, associated methods.

Abstract: A system using a URN scheme and having a server 50 connected to a global computer network 40, and registered computerized station 20 connected to a cellular network 10, with both networks interconnected through an SMS gateway 30, having an application that resides in each computerized station. The application or the server is capable of encrypting SMS messages to prevent unauthorized third-parties from intercepting sensitive data. The SMS messages travel encrypted until reaching their intended recipient upon which time the application residing in the registered user computer station will decrypt and use the original message.

Abstract: The present disclosure relates to the production of platelets from megakaryocytes (Mks). In particular, the present disclosure provides systems and methods for the in vitro production of platelets from Mks using a microfluidic bioreactor having a center flow channel and uniform high-shear micrometer slits. Use of this microfluidic bioreactor enables the continuous production of millions of platelets and facilitates real-time and long-term visualization of proplatelet and platelet generation.