Patents by Inventor Andrea Adamo
Andrea Adamo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240050874Abstract: Devices and methods for separating multi-phase fluids, comprising a first porous medium portion and a second porous medium portion. The device comprises a fluidic channel comprising an inlet; the first porous medium portion between the fluidic channel and a first auxiliary outlet; and the second porous medium portion between the fluidic channel and a second auxiliary outlet. The method comprises presenting a combined flow comprising a first fluid phase and a second fluid phase to a separator, wherein the first porous medium portion has a higher affinity for the first fluid phase than for the second fluid phase, and the second porous medium portion has a higher affinity for the second fluid phase than for the first fluid phase.Type: ApplicationFiled: January 7, 2022Publication date: February 15, 2024Applicant: Zaiput Flow Technologies LLCInventors: Andrea Adamo, Kevin Sheehan, Colin O'Shea
-
Patent number: 11878996Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: GrantFiled: December 18, 2020Date of Patent: January 23, 2024Assignee: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
-
Publication number: 20230416217Abstract: The present disclosure is related to the separation of chemical species using multiple liquid phases.Type: ApplicationFiled: January 6, 2023Publication date: December 28, 2023Applicant: Zaiput Flow Technologies LLCInventors: Lorenzo Milani, Trevor Charles Murray, Robert Viano, Andrea Adamo
-
Publication number: 20230405489Abstract: The present disclosure is related to the continuous liquid-liquid chromatographic separation of chemical species using multiple liquid phases and related systems and articles.Type: ApplicationFiled: June 15, 2022Publication date: December 21, 2023Applicant: Zaiput Flow Technologies LLCInventors: Lorenzo Milani, Trevor Charles Murray, Robert Viano, Andrea Adamo, Róbert Örkényi
-
Publication number: 20230201787Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.Type: ApplicationFiled: December 21, 2022Publication date: June 29, 2023Applicant: Massachusetts Institute of TechnologyInventors: Klavs F. Jensen, Timothy F. Jamison, Allan Stuart Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang
-
Publication number: 20230174572Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.Type: ApplicationFiled: May 18, 2022Publication date: June 8, 2023Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
-
Publication number: 20230130686Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.Type: ApplicationFiled: October 25, 2021Publication date: April 27, 2023Applicant: Massachusetts Institute of TechnologyInventors: Armon R. Sharei, Andrea Adamo, Robert S. Langer, Klavs F. Jensen
-
Patent number: 11565230Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.Type: GrantFiled: August 10, 2020Date of Patent: January 31, 2023Assignee: Massachusetts Institute of TechnologyInventors: Klavs F. Jensen, Timothy F. Jamison, Allan S. Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang
-
Patent number: 11548864Abstract: The present disclosure is related to the separation of chemical species using multiple liquid phases.Type: GrantFiled: June 15, 2022Date of Patent: January 10, 2023Assignee: Zaiput Flow Technologies LLCInventors: Lorenzo Milani, Trevor Charles Murray, Robert Viano, Andrea Adamo
-
Publication number: 20220275021Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: ApplicationFiled: December 21, 2021Publication date: September 1, 2022Applicant: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
-
Publication number: 20220118379Abstract: Method of separation of a radiometal ion from a target metal ion, comprising a first liquid-liquid extraction step in which an organic phase comprising an extractant and an interfacial tension modifier is mixed with an aqueous phase comprising the radiometal ion and the target metal ion in order that the radiometal ion is at least partially transferred to the organic phase, followed by a first phase separation step, wherein the phase separation is carried out in flow comprising the use of a microfiltration membrane to separate the phases based on the interfacial tension between the phases such that a permeate phase passes through the membrane and a retentate phase does not.Type: ApplicationFiled: August 6, 2019Publication date: April 21, 2022Inventors: Fedor ZHURAVLEV, Kristina Søborg PEDERSEN, Jesper FONSLET, Joseph Michael IMBROGNO, Andrea ADAMO, Klavs F. JENSEN
-
Patent number: 11185839Abstract: The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.Type: GrantFiled: May 2, 2017Date of Patent: November 30, 2021Assignee: Massachusetts Institute of TechnologyInventors: Andrea Adamo, Dale Arlington Thomas, III, Klavs F. Jensen, Timothy F. Jamison, Aaron A. Bedermann, Kosisochukwu C. Aroh
-
Publication number: 20210190062Abstract: Liquid pumps and related systems and methods are generally described.Type: ApplicationFiled: October 20, 2020Publication date: June 24, 2021Applicant: Zaiput Flow Technologies LLCInventors: Andrea Adamo, Kevin Sheehan
-
Publication number: 20210188901Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.Type: ApplicationFiled: October 30, 2020Publication date: June 24, 2021Applicant: Massachusetts Institute of TechnologyInventors: Dale Arlington Thomas, III, Alexander James Mijalis, Bradley L. Pentelute, Mark David Simon, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
-
Publication number: 20210188899Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: ApplicationFiled: December 18, 2020Publication date: June 24, 2021Applicant: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
-
Publication number: 20210188900Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: ApplicationFiled: December 18, 2020Publication date: June 24, 2021Applicant: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
-
Patent number: 10988504Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: GrantFiled: September 5, 2017Date of Patent: April 27, 2021Assignee: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
-
Patent number: 10987671Abstract: Reservoir-based management of volumetric flow rates in fluidic systems is generally described. Inventive systems and methods for liquid-liquid separations and/or liquid-gas separations are also described.Type: GrantFiled: April 5, 2019Date of Patent: April 27, 2021Assignee: Zaiput Flow Technologies LLCInventors: Andrea Adamo, Robert Andrew Butters, Trevor Charles Murray
-
Patent number: 10889613Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.Type: GrantFiled: May 22, 2017Date of Patent: January 12, 2021Assignee: Massachusetts Institute of TechnologyInventors: Mark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
-
Publication number: 20200368710Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.Type: ApplicationFiled: August 10, 2020Publication date: November 26, 2020Applicant: Massachusetts Institute of TechnologyInventors: Klavs F. Jensen, Timothy F. Jamison, Allan S. Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang