Patents by Inventor Andrea Castellin

Andrea Castellin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF BRINZOLAMIDE
    Publication number: 20110118461
    Abstract: The present invention relates to a process for the preparation of Brinzolamide, or 2H-thieno[3,2-e]-1, 2-thiazin-6-sulfonamide, 4-(ethyl amino)-3, 4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide,(4R)- via intermediates 2,3-dihydro-4H-thieno[3,2-e]-1, 2-thiazin-4-ones, 1,1-dioxide. Further objects of the present invention are the intermediates mentioned above and other intermediates of the synthesis.
    Type: Application
    Filed: June 15, 2009
    Publication date: May 19, 2011
    Inventors: Alessandro Falchi, Ottorino De Lucchi, Andrea Castellin
  • PROCESS FOR THE PREPARATION OF OLOPATADINE
    Publication number: 20110065936
    Abstract: The present invention relates to a novel process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
    Type: Application
    Filed: March 23, 2010
    Publication date: March 17, 2011
    Inventors: Andrea Castellin, Clark Ferrari, Marco Galvagni
  • Intermediates for the preparation of citalopram and escitalopram
    Patent number: 7687645
    Abstract: Methods for manufacture of 5-alkoxycarbonylphthtalides are disclosed. The 5-alkoxycarbonylphthtalides are useful in syntheses of the well-known antidepresssants citalopram and escitalopram.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: March 30, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Thomas Pittelkow, Andrea Castellin, Federico Sbrogiò, Poul D. Nielsen, Jacobo Zanon, Steen Sogaard, Rikke E. Humble
  • Process for the preparation of ziprasidone
    Patent number: 7608711
    Abstract: A process for the preparation of ziprasidone and a novel intermediate useful in its preparation. The process comprises the reduction of a compound (III) to give a compound (V) which is then reduced to compound (II). This is reacted with compound (IV) to give the desired compound.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: October 27, 2009
    Assignee: Dipharma Francis Srl
    Inventors: Jacopo Zanon, Oscar Martini, Francesco Ciardella, Luca Gregori, Federico Sbrogio, Andrea Castellin
  • Process for the synthesis and purification of (4-methoxybutyl) (4-trifluoromethylphenyl) methanone
    Publication number: 20090264680
    Abstract: A process for the preparation of 4-trifluoromethylvalerophenone is described. The process described is a three step process comprising the synthesis of organomagnesium specie, coupling reaction between the organomagnesium specie and trifluoromethylbenzonitrile or trifluoromethylbenzoyl chloride and preferably a purification of the product obtained in suitable reaction conditions. In the process an extraction phase of the final product is not required.
    Type: Application
    Filed: July 7, 2004
    Publication date: October 22, 2009
    Inventors: Andrea Castellin, Luca Gregori, Guadalupe Gonzales Trueba, Albino Rubello, Andrea Nicole
  • Method for the Preparation of Escitalopram
    Publication number: 20090247772
    Abstract: The invention relates to intermediates and the use thereof in a method for the preparation of escitalopram:
    Type: Application
    Filed: November 14, 2006
    Publication date: October 1, 2009
    Applicant: H. Lundbeck A/S
    Inventors: Antonio Paulon, Ottorino De Lucchi, Andrea Castellin, Fabrizio Fabris, Federico Sbrogio, Emanuele Ceron, Hans Petersen, Robert Dancer
  • Process for the preparation of ziprasidone
    Publication number: 20070117810
    Abstract: A process for the preparation of ziprasidone and a novel intermediate useful in its preparation. The process comprises the reduction of a compound (III) to give a compound (V) which is then reduced to compound (II). This is reacted with compound (IV) to give the desired compound.
    Type: Application
    Filed: November 13, 2006
    Publication date: May 24, 2007
    Applicants: DIPHARMA S. P. A., LUNDBECK PHARMACEUTICALS ITALY S. P. A.
    Inventors: Jacopo Zanon, Oscar Martini, Francesco Ciardella, Luca Gregori, Federico Sbrogio, Andrea Castellin
  • Process for the preparation of pure citalopram
    Patent number: 6855834
    Abstract: A process for the preparation of citalopram of formula (I) in which a compound of formula (II) wherein Z is iodo, bromo, chloro or CF3—(CF2)n—SO2—O— n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction in which the group Z is exchanged with cyanide by reaction with a cyanide source; the resultant crude citalopram product is optionally subjected to some initial purification and the crude citalopram base is subsequently subjected to a film distillation process; the resulting citalopram product is then optionally further purified and worked up and isolated as the base or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: February 15, 2005
    Assignee: H. Lundbeck A/S
    Inventors: Andrea Castellin, Giulio Volpe, Federico Sbrogiò
  • Process for the preparation of pure citalopram
    Publication number: 20030178295
    Abstract: A process for the preparation of citalopram of formula (I) 1
    Type: Application
    Filed: February 10, 2003
    Publication date: September 25, 2003
    Applicant: H. LUNDBECK A/S
    Inventors: Andrea Castellin, Giulio Volpe, Federico Sbrogio
  • Method for the preparation of citalopram
    Publication number: 20020128497
    Abstract: A method for the manufacture of citalopram characterized in (i) reaction of 1-(4-fluorophenyl)-1-(3-dimethylaminopropyl)-5-halophthalane with an activated magnesium to form the Grignard reagent [3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1-yl]propyl]dimethylamine 5-magnesium halide followed by (ii) reaction of [3-[1-(4-fluorophenyl)-1,3 dihydro-isobenzofuran-1-yl]propyl)dimethylamine 5-magnesium halide with a compound containing a —CN group bound to a leaving group to form citalopram.
    Type: Application
    Filed: March 6, 2002
    Publication date: September 12, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Eva Bolzonella, Andrea Castellin, Andrea Nicole
  • Process for the preparation of pure citalopram
    Publication number: 20020087012
    Abstract: A process for the preparation of citalopram of formula (I) 1
    Type: Application
    Filed: December 20, 2001
    Publication date: July 4, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Andrea Castellin, Giulio Volpe, Federico Sbrogio