Patents by Inventor Andrea Mattevi

Andrea Mattevi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGIOSELECTIVE HYDROXYLATION OF ISOPHORONE
    Publication number: 20210108234
    Abstract: The present invention relates to novel process for the production of ketoisophorone via biocatalytic conversion of isophorone, in particular a one-pot biocatalytic system for conversion of ?-isophorone in a two-step oxidation process, with a first oxidation being catalyzed by a heme containing oxidoreductase such as a cytochrome P450 monooxygenase followed by another oxidation which can be either a chemical reaction or a biocatalytic reaction, in particular wherein the oxidation is catalyzed by an NAD(P) or NADP(H)-dependent oxidoreductase. The invention further provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified (higher) substrate selectivity, total turnover numbers and/or (re)activity compared to the wild-type enzyme. Ketoisophorone is useful as building block in the synthesis of vitamins and carotenoids.
    Type: Application
    Filed: April 6, 2018
    Publication date: April 15, 2021
    Inventors: Werner BONRATH, Martin SCHÜRMANN, Michele TAVANTI, Fabio PARMEGGIANI, Nicholas TURNER, Andrea MATTEVI, Jose Ruben CASSTELLANOS
  • Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
    Patent number: 8765820
    Abstract: Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: July 1, 2014
    Assignees: Universita Degli Studi di Roma “La Sapienza”, Fondazione IEO, Universita Degli Studi di Pavia, Universita Degli Studi di Milano
    Inventors: Saverio Minucci, Antonello Mai, Andrea Mattevi
  • TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2
    Publication number: 20130035377
    Abstract: Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.
    Type: Application
    Filed: April 15, 2011
    Publication date: February 7, 2013
    Applicants: UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA", UNIVERSITÀ DEGLI STUDI DI MILANO, UNIVERSITÀ DEGLI STUDI DI PAVIA, FONDAZIONE IEO
    Inventors: Saverio Minucci, Antonello Mai, Andrea Mattevi