Abstract: The present disclosure provides methods and intermediates for making Compound A or a pharmaceutical salt thereof, and/or a solvate of, which are useful as methods and intermediates for producing compounds for treating diseases and conditions related to mutant KIT and PDGFRA.

Abstract: A sheet-like element made of brittle material includes two opposing side faces and a peripheral edge face which determines an outer contour of the sheet-like element. The edge face has at least one first region and at least one second region. The at least one first region differs from the at least one second region in terms of its surface structure. The at least one first region has an etched surface and the at least one second region constitutes a fractured surface. A surface area of the at least one first region is larger than a surface area of the at least one second region. The at least one first region and the at least one second region are arranged next to one another in a direction along the edge face.

Abstract: A process for recovering isoprenol essentially free of formaldehyde from a stream of crude isoprenol containing isoprenol, water and formaldehyde, the process comprising subjecting the stream of crude isoprenol or an isoprenol containing fraction thereof to distillation in a low-boiler separation tower operated at a pressure of 2.5 bara or higher to obtain a distillate stream containing aqueous formaldehyde and a bottoms stream containing isoprenol. The process of the invention allows for obtaining isoprenol essentially free of formaldehyde. Further provided is a plant for recovering isoprenol essentially free of formaldehyde from a stream of crude isoprenol containing isoprenol, water and formaldehyde, the plant comprising a first low-boiler separation tower, a second low-boiler separation tower, and a finishing tower.

Abstract: The present invention relates to dust-free preparations dispersible in cold water. These preparations consist of particles comprising water-insoluble or only sparingly water-soluble active substance(s), said particles being coated with one or more layers, the outermost layer comprising as principal component one or more hydrophobic powdering agents on which at least one dispersant is absorbed. The invention also relates to a process for producing these particles and to the use thereof in food supplements, foodstuffs, animal feeds, personal-care products, and medicaments.

Abstract: A nonwoven web is made by displacing an air-permeable mesh-belt conveyor in a horizontal travel direction and spinning and then depositing crimped continuous filaments as a web at a deposit region on the air-permeable mesh-belt conveyor. A first preconsolidation stage is provided downstream of the deposit region and a second preconsolidation separated by a suction gap from the first stage. Air is drawn air through the web and the conveyor at the deposit region at a first predetermined speed, the first and second consolidation stages at a second and third predetermined speeds, and at the suction gap either not at all or at a fourth predetermined equal to at most substantially less than the second predetermined speed.

Abstract: A method for determining a nonlinearity characteristic of a receiver path includes generating a set of N×M digital samples by repeating N times selecting an scaling factor from a set of N scaling factors, generating a version of a test signal, the version of the test signal corresponding to a test signal scaled by the respective scaling factor, processing the respective version of the test signal in at least a part of the receiver path to generate a respective processed signal, and storing M digital samples corresponding to the respective processed signal. Fourier-transformed data are generated using at least a portion of the set of N×M digital samples and a nonlinearity characteristic of the receiver path is determined based on the Fourier-transformed data.

Abstract: Embodiments disclosed herein include electronic package and methods of forming such packages. In an embodiment, an electronic package comprises a mold layer and a first die embedded in the mold layer. In an embodiment, the first die comprises first pads at a first pitch and second pads at a second pitch. In an embodiment, the electronic package further comprises a second die embedded in the mold layer, where the second die comprises third pads at the first pitch and fourth pads at the second pitch. In an embodiment, a bridge die is embedded in the mold layer, and the bridge die electrically couples the second pads to the fourth pads.

Abstract: A method includes producing filamentary damages in a volume of a glass or glass ceramic element that are adjacently aligned along a separation line and that extend obliquely relative to a surface of the glass or glass ceramic element, and separating a portion from the glass or glass ceramic element along the separation line. The step of producing the filamentary damages includes directing laser pulses of an ultrashort pulse laser obliquely on the surface so that the laser pulses have a light propagation direction that extends obliquely relative to the surface and so that the filamentary damages resulting from the laser pulses have the longitudinal extension that extends obliquely relative to the surface, generating a plasma within the volume with the laser pulses, and displacing the laser pulses at points of incidence over the surface along the separation line.

Abstract: A method for processing glass is provided. The method includes the steps of providing a glass element and removing glass material from the glass element by etching with an alkaline etching medium in an organic solvent.

Abstract: A system for producing plastic containers with a heating device for heating plastic preforms, wherein the heating device has a transport device for transporting plastic preforms along a predetermined first transport path, and a plurality of holding devices for holding the plastic preforms and at least one heating device which heats the plastic preforms during the transport thereof and comprising a forming device for forming the plastic preforms to form plastic containers. The forming device is configured for expanding the plastic preforms heated by the heating device by applying a flowable medium, and includes a plurality of forming stations which form the plastic preforms to form the plastic containers. Both the heating device and the forming device have changeable elements, wherein the system has a changing device configured for changing both changeable elements of the heating device and changeable elements of the forming device.

Abstract: A chip assembly having a carrier having a cavity and at least one carrier contact, a chip arranged in the cavity and having at least one chip contact, and a wirebond wire, which electrically conductively connects the at least one chip contact to the at least one carrier contact, wherein the wirebond wire is flat-pressed in at least one subregion.

Abstract: An electrical circuit for providing an output signal based on a first input signal and a second input signal has: a mixer which is configured to receive and mix the first and second input signals in order to generate a mixer output signal and to switch on or off based on the first input signal, wherein a DC signal component of the mixer output signal depends on whether the mixer is switched on or off; and a downstream circuit which is configured to switch on or off based on the DC signal component of the mixer output signal and to provide the output signal based on the mixer output signal.

Abstract: A method and apparatus for producing glass products from tubular glass precursors is provided. In particular, a method and apparatus for separating tube glass into sized glass tube portions, produced glass tube portions, glass precursor portions, or glass product portions, and their use as pharmaceutical packaging are provided. The tube glass or the glass precursor or the glass product is provided with filaments along predetermined breaking planes. The filaments extend obliquely to the local wall radius and allow for clean separation of the tube glass or the glass precursor or the glass product.

Abstract: A method of producing a lipid-encapsulated RNA nanoparticle, comprising the steps a) flowing an aqueous solution comprising an RNA through a 1st tube having an inner diameter (ID) of between about 0.1? and 0.132?; b) flowing an ethanol solution comprising lipids through a 2nd tube having an ID of between about 0.005? and 0.02? at one third the flow rate of the aqueous solution through the 1st tube, wherein the lipids comprise a cationic lipid; and c) mixing the ethanol solution with the aqueous solution by flowing the ethanol solution and the aqueous solution into a mixing module consisting of the 2nd tube perpendicularly joined to the 1st tube; wherein the mixing produces an output solution flowing in the 1st tube comprising a turbulent flow of the RNA and the lipids in between about 10% to 75% ethanol v/v, and wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.

Abstract: A water drainage duct for draining water from a dual gasket assembly, wherein the dual gasket assembly is suitable for sealing an abutment joint between two wall panels, the dual gasket assembly comprising a support coupling, a compressible interior gasket, and a compressible weather gasket, with the support coupling comprising a base having at least one gutter channel for directing water, the water drainage duct comprising a body having an attachment accessory for attachment to the support coupling of a dual gasket assembly, the body further having a water collection area, a water drainage channel, and a compressible gasket having an exterior port, wherein the water collection area is in fluid communication with the exterior port in the compressible gasket via the water drainage channel to allow water to move by gravity from the water collection area to and through the exterior port.

Abstract: Process for making a wall panel module comprising a wall panel and at least one dual gasket assembly, the process including steps of a) forming a first dual gasket assembly comprising a compressible interior gasket, a support coupling, and a compressible weather gasket, b) providing a first wall panel, having major faces that form parallel planes, c) positioning the first dual gasket assembly adjacent to the first edge face of the first panel, the lengths of the compressible interior gasket and the compressible weather gasket being parallel to the edge face length, with both gaskets further bounded by the parallel planes, d) attaching the support coupling of the first dual gasket assembly to the first edge face of the first wall panel.

Abstract: Gaps between adjacent members in a building construction are sealed by applying a self-adhering barrier sheet to the adjacent members to span the gap. The self-adhering barrier sheet includes a flexible sheet of a barrier material. The flexible sheet has opposing edges, of which at least one is tapered. A pressure sensitive adhesive is applied to at least a portion of at least one major surface of the flexible sheet. The edges of the self-adhering barrier sheet are adhered to the adjacent structural elements by means of the pressure sensitive adhesive. The pressure sensitive adhesive has a thickness equal to or less than the maximum thickness of the flexible sheet. Where two self adhering barrier sheets overlap at an angle on a substrate, the tapered edge of the underlying sheet allows a smooth transition for the overlapping sheet, preventing the formation of an open gap between the barrier sheets and the substrate where air and moisture can penetrate.

Abstract: A computer system, processor, and method for processing information is disclosed that includes at least one computer processor; a main register file associated with the at least one processor, the main register file having a plurality of entries for storing data, one or more write ports to write data to the main register file entries, and one or more read ports to read data from the main register file entries; one or more execution units including a dense math execution unit; and at least one accumulator register file having a plurality of entries for storing data. The results of the dense math execution unit in an aspect are written to the accumulator register file, preferably to the same accumulator register file entry multiple times, and the data from the accumulator register file is written to the main register file.

Abstract: Processes for making a tilt wall comprising a sealed abutment joint between two concrete wall panels comprising a first wall panel, a dual gasket assembly, and a second wall panel, wherein the dual gasket assembly comprises an interior gasket, a support coupling, and a weather gasket, with the support coupling attached to a first edge face of the first wall panel by the metallic channel, wherein the first and second wall panels are aligned adjacent to one another in the same plane, with the support coupling positioned between the first edge face of the first wall panel and a second edge face of the second wall panel, the second edge face of the second wall panel positioned relative to the first wall panel a desired distance proximate the first edge face to form a desired breadth of the abutment joint between the edge faces; and the interior gasket and the outer weather gasket in contact with and compressed against both the first and second edge faces to seal the abutment joint between the edge faces.

Abstract: A wall panel module comprising a first wall panel and one or more dual gasket assembly, the dual gasket assembly being suitable for sealing an abutment joint between edge faces of two wall panels and comprising a support coupling, a compressible interior gasket, and a compressible weather gasket, the support coupling comprising a base having a top surface having an interior gasket support and an exterior gasket support on opposing ends of the support coupling, the compressible interior gasket attached to the interior gasket support and the compressible outer weather gasket attached to the exterior gasket support, the compressible interior gasket and the compressible outer weather gasket mounted on the support coupling with the lengths of the compressible interior gasket and the compressible outer weather gasket parallel to one another and also being parallel to the dual gasket assembly length, the bottom surface of the support coupling base further having an attachment area with the dual gasket assembly attac