Patents by Inventor Andreas Calatzis
Andreas Calatzis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11977601Abstract: A computer-implemented method for supplementing measurement results of automated analyzers is presented. The method includes obtaining, at a computer device, a result of a measurement performed by an automated analyzer, the computer device and the automated analyzer being located within a privileged computer network, obtaining a context related algorithm associated with the result of the measurement defining one or more triggering conditions and context related information from a computer device residing outside of the privileged computer network at the computer device and processing the result of the measurement by using the context related algorithm to generate a context specific supplement to the result of the measurement at the computer device.Type: GrantFiled: November 10, 2020Date of Patent: May 7, 2024Assignee: Roche Diagnostics Operations, Inc.Inventors: Andreas Calatzis, Felix Dross, Marianne Wilmer, Simon Davidson
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Publication number: 20220119550Abstract: The invention relates to therapies for a patient with bleeding disorders, comprising the application of certain blood coagulation (clotting) factors in combination with antibodies.Type: ApplicationFiled: April 20, 2021Publication date: April 21, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Andreas Calatzis, Katharina Lechner
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Patent number: 11150256Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.Type: GrantFiled: August 20, 2018Date of Patent: October 19, 2021Assignee: Roche Diagnostics Operations, Inc.Inventors: Friedrich Ackermann, Andreas Calatzis, Rik Harbers, Roland Hutter, Jean-Pierre Bolliger, Theresa Kitcoff, Patrick Sascha Labud
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Publication number: 20210056163Abstract: A computer-implemented method for supplementing measurement results of automated analyzers is presented. The method includes obtaining, at a computer device, a result of a measurement performed by an automated analyzer, the computer device and the automated analyzer being located within a privileged computer network, obtaining a context related algorithm associated with the result of the measurement defining one or more triggering conditions and context related information from a computer device residing outside of the privileged computer network at the computer device and processing the result of the measurement by using the context related algorithm to generate a context specific supplement to the result of the measurement at the computer device.Type: ApplicationFiled: November 10, 2020Publication date: February 25, 2021Applicant: Roche Diagnostics Operations, Inc.Inventors: Andreas Calatzis, Felix Dross, Marianne Wilmer, Simon Davidson
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Patent number: 10909213Abstract: A computer-implemented method for supplementing measurement results of automated analyzers is presented. The method includes obtaining, at a computer device, a result of a measurement performed by an automated analyzer, the computer device and the automated analyzer being located within a privileged computer network, obtaining a context related algorithm associated with the result of the measurement defining one or more triggering conditions and context related information from a computer device residing outside of the privileged computer network at the computer device and processing the result of the measurement by using the context related algorithm to generate a context specific supplement to the result of the measurement at the computer device.Type: GrantFiled: November 13, 2017Date of Patent: February 2, 2021Assignee: Roche Diagnostics Operations, Inc.Inventors: Andreas Calatzis, Felix Dross, Marianne Wilmer, Simon John Davidson
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Patent number: 10379014Abstract: A method for preparing a biological sample for analysis is provided that includes moving a continuous substrate film past a sample applicator unit including one or more sample applicators and applying at least one trace of a biological sample to be analyzed onto the continuous substrate film by the sample applicator unit.Type: GrantFiled: November 21, 2016Date of Patent: August 13, 2019Assignee: Roche Diagnostics Operations, Inc.Inventors: Andreas Calatzis, Harald Leyser
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Patent number: 10337048Abstract: The present invention concerns diagnostic methods for coagulation testing involving determining anticoagulant activity elicited by a first anticoagulant in a sample comprising measuring a first Factor Xa activity in a body fluid test sample of said subject, measuring a second Factor Xa activity in at least one calibrator sample comprising a predefined anticoagulation activity for a second anticoagulant, calculating an universal parameter for the anticoagulation activity comprised in the test sample based on the first and the second measured Factor Xa activities and comparing the said parameter for the anticoagulation activity with predefined ranges of expected anticoagulation activity for at least three anticoagulants. Further provided is a computer program code assisting the method as well as a system for carrying out the said method as well as a kit.Type: GrantFiled: December 11, 2015Date of Patent: July 2, 2019Assignee: Roche Diagnostics Operations, Inc.Inventors: Friedrich Ackermann, Andreas Calatzis
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Publication number: 20190004075Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.Type: ApplicationFiled: August 20, 2018Publication date: January 3, 2019Applicant: Roche Diagnostics Operations, Inc.Inventors: Friedrich Ackermann, Andreas Calatzis, Rik Harbers, Roland Hutter, Jean-Pierre Bolliger, Theresa Kitcoff, Patrick Sascha Labud
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Patent number: 10082517Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.Type: GrantFiled: March 30, 2016Date of Patent: September 25, 2018Inventors: Friedrich Ackermann, Andreas Calatzis, Rik Harbers, Roland Hutter, Jean-Pierre Bolliger, Theresa Kitcoff, Patrick Sascha Labud
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Publication number: 20180244798Abstract: The invention relates to therapies for a patient with bleeding disorders, comprising the application of certain blood coagulation (clotting) factors in combination with antibodies.Type: ApplicationFiled: October 16, 2017Publication date: August 30, 2018Applicant: Hoffmann-La Roche Inc.Inventors: Andreas Calatzis, Katharina Lechner
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Publication number: 20180143944Abstract: A computer-implemented method for supplementing measurement results of automated analyzers is presented. The method includes obtaining, at a computer device, a result of a measurement performed by an automated analyzer, the computer device and the automated analyzer being located within a privileged computer network, obtaining a context related algorithm associated with the result of the measurement defining one or more triggering conditions and context related information from a computer device residing outside of the privileged computer network at the computer device and processing the result of the measurement by using the context related algorithm to generate a context specific supplement to the result of the measurement at the computer device.Type: ApplicationFiled: November 13, 2017Publication date: May 24, 2018Applicant: Roche Diagnostics Operations, Inc.Inventors: Andreas Calatzis, Felix Dross, Marianne Wilmer, Simon John Davidson
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Publication number: 20170261526Abstract: A method for monitoring the performance of an analyzer for biological samples having an automated preparation device is presented. The method comprises receiving an instruction that a monitoring procedure shall be executed, after receipt of the instruction that a monitoring procedure shall be executed, obtaining, by the automated preparation device, at least two quality control ingredients from a repository including a plurality of quality control ingredients, and mixing, by the automated preparation device, the at least two quality control ingredients in a sample preparation receptacle to obtain a quality control which mimics the properties of a biological sample to be analyzed by the analyzer. The method further comprises determining at least one parameter of the quality control and determining a status of the analyzer based on the determined parameter of the quality control.Type: ApplicationFiled: March 6, 2017Publication date: September 14, 2017Inventors: Andreas Calatzis, Felix Dross
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Publication number: 20170146437Abstract: A method for preparing a biological sample for analysis is provided that includes moving a continuous substrate film past a sample applicator unit including one or more sample applicators and applying at least one trace of a biological sample to be analyzed onto the continuous substrate film by the sample applicator unit.Type: ApplicationFiled: November 21, 2016Publication date: May 25, 2017Inventors: Andreas Calatzis, Harald Leyser
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Publication number: 20160326568Abstract: The present invention concerns diagnostic methods for coagulation testing involving determining anticoagulant activity elicited by a first anticoagulant in a sample comprising measuring a first Factor Xa activity in a body fluid test sample of said subject, measuring a second Factor Xa activity in at least one calibrator sample comprising a predefined anticoagulation activity for a second anticoagulant, calculating an universal parameter for the anticoagulation activity comprised in the test sample based on the first and the second measured Factor Xa activities and comparing the said parameter for the anticoagulation activity with predefined ranges of expected anticoagulation activity for at least three anticoagulants. Further provided is a computer program code assisting the method as well as a system for carrying out the said method as well as a kit.Type: ApplicationFiled: December 11, 2015Publication date: November 10, 2016Inventors: Friedrich Ackermann, Andreas Calatzis
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Publication number: 20160299164Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.Type: ApplicationFiled: March 30, 2016Publication date: October 13, 2016Inventors: Friedrich Ackermann, Andreas Calatzis, Rik Harbers, Roland Hutter, Jean-Pierre Bolliger, Theresa Kitcoff, Patrick Sascha Labud
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Patent number: 8877510Abstract: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyzer.Type: GrantFiled: November 22, 2013Date of Patent: November 4, 2014Assignee: F. Hoffmann-La Roche AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Publication number: 20140154810Abstract: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyser.Type: ApplicationFiled: November 22, 2013Publication date: June 5, 2014Applicant: F. HOFFMANN-LA ROCHE AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Patent number: 8591816Abstract: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyzer.Type: GrantFiled: February 17, 2011Date of Patent: November 26, 2013Assignee: F. Hoffmann-La Roche AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Patent number: 8465978Abstract: Methods and devices for conducting platelet aggregation analysis. A method for conducting platelet aggregation analysis by a cartridge device, including providing a blood sample in the cartridge device, stirring the blood sample within the cartridge device, measuring the electrical impedance between electrodes to obtain measured electrical impedance values, comparing measured electrical impedance values, discarding and repeating the measurements of the electrical impedance in case a variation of the measurements is outside a predetermined threshold range, or reporting the measured electrical impedance values in case the variation of the measurements is within the predetermined threshold range. Reported measured electrical impedance values indicate platelet aggregation in a blood sample.Type: GrantFiled: February 17, 2011Date of Patent: June 18, 2013Assignee: F. Hoffmann-la Roche AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Publication number: 20110136164Abstract: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyser.Type: ApplicationFiled: February 17, 2011Publication date: June 9, 2011Inventors: Andreas Calatzis, Ben Krüger, Marc Wittwer