Patents by Inventor Andreas Crameri

Andreas Crameri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES
    Publication number: 20200277659
    Abstract: Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy.
    Type: Application
    Filed: March 30, 2020
    Publication date: September 3, 2020
    Inventors: Andreas CRAMERI, Malcolm Leithhead HILL, David Graham TEW
  • Processes for the production of oligonucleotides
    Patent number: 10640812
    Abstract: Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: May 5, 2020
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Andreas Crameri, Malcolm Leithhead Hill, David Graham Tew
  • Biologically active proteins having increased in vivo and/or in vitro stability
    Patent number: 9938331
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: April 10, 2018
    Assignee: Amunix Operating Inc.
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-Wei Wang, Michael D. Scholle, Nathaniel C. Gordon, Andreas Crameri, Mikhail Popkov
  • NOVEL PROCESSES FOR THE PRODUCTION OF OLIGONUCLEOTIDES
    Publication number: 20180023122
    Abstract: Disclosed herein are novel processes for the production of oligonucleotides that are suitable for use in the production of chemically modified oligonucleotides, such as those for use in therapy.
    Type: Application
    Filed: July 7, 2017
    Publication date: January 25, 2018
    Inventors: Andreas CRAMERI, Malcolm Leithhead Hill, Sarah Louise Lovelock, Markus Schober, David Graham Tew, Pamela Joan Thomas
  • MODIFIED THERAPEUTIC AGENTS AND COMPOSITIONS THEREOF
    Publication number: 20160287713
    Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. One or more half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents (mTAs) comprising one or more half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.
    Type: Application
    Filed: September 12, 2014
    Publication date: October 6, 2016
    Inventors: Weijun SHEN, Peter G. SCHULTZ, Avinash MUPPIDI, Andreas CRAMERI, Insha AHMAD, Pengyu YANG
  • BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY
    Publication number: 20160280753
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: December 16, 2015
    Publication date: September 29, 2016
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-Wei Wang, Michael D. Scholle, Nathaniel C. Gordon, Andreas Crameri, Mikhail Popkov
  • BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY
    Publication number: 20140356326
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: December 10, 2013
    Publication date: December 4, 2014
    Applicant: Amunix Operating Inc.
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-Wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • Unstructured recombinant polymers and compositions comprising same
    Patent number: 8492530
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: July 23, 2013
    Assignee: Amunix Operating Inc.
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-Wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • METHODS FOR GENERATING POLYNUCLEOTIDES HAVING DESIRED CHARACTERISTICS BY ITERATIVE SELECTION AND RECOMBINATION
    Publication number: 20120252701
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Application
    Filed: August 18, 2011
    Publication date: October 4, 2012
    Applicant: CODEXIS, INC.
    Inventors: Willem P.C. Stemmer, Andreas Crameri
  • BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY
    Publication number: 20120230947
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: April 4, 2012
    Publication date: September 13, 2012
    Applicant: AMUNIX OPERATING INC.
    Inventors: VOLKER SCHELLENBERGER, WILLEM P. STEMMER, CHIA-WEI WANG, MICHAEL D. SCHOLLE, MIKHAIL POPKOV, NATHANIEL C. GORDON, ANDREAS CRAMERI
  • UNSTRUCTURED RECOMBINANT POLYMERS AND USES THEREOF
    Publication number: 20120220011
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: February 14, 2012
    Publication date: August 30, 2012
    Applicant: Amunix Operating Inc.
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • OLIGONUCLEOTIDE MEDIATED NUCLEIC ACID RECOMBINATION
    Publication number: 20120040871
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: September 23, 2011
    Publication date: February 16, 2012
    Applicant: CODEXIS MAYFLOWER HOLDINGS, LLC
    Inventors: Andreas Crameri, Willem PC Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A Patten
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 8058001
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: November 15, 2011
    Assignee: Codexis Mayflower Holdings LLC
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, John E. Ness, Claes Gustafsson, Phillip A. Patten
  • Oligonucleotide mediated nucleic acid recombination
    Patent number: 8029988
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: October 4, 2011
    Assignee: Codexis Mayflower Holdings, LLC
    Inventors: Andreas Crameri, Willem P. C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • Integrated systems and methods for diversity generation and screening
    Patent number: 8014961
    Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: September 6, 2011
    Assignee: Codexis Mayflower Holdings, LLC
    Inventors: Steven H. Bass, Simon Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy S. Minshull, Mark Welch, Claus Gustafsson, Brian Carr, Stephan J. Jenne, Sun Ai Raillard, Andreas Crameri, Willem P. C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
  • Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
    Patent number: 7981614
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: July 19, 2011
    Assignee: Codexis Mayflower Holdings LLC
    Inventors: Willem P. C. Stemmer, Andreas Crameri
  • UNSTRUCTURED RECOMBINANT POLYMERS AND COMPOSITIONS COMPRISING SAME
    Publication number: 20110171687
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: November 3, 2010
    Publication date: July 14, 2011
    Applicant: Amunix Operating, Inc.
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • METHODS FOR PRODUCTION OF UNSTRUCTURED RECOMBINANT POLYMERS AND USES THEREOF
    Publication number: 20110151433
    Abstract: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
    Type: Application
    Filed: November 3, 2010
    Publication date: June 23, 2011
    Applicant: Amunix Operating, Inc.
    Inventors: Volker Schellenberger, Willem P. Stemmer, Chia-Wei Wang, Michael D. Scholle, Mikhail Popkov, Nathaniel C. Gordon, Andreas Crameri
  • Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
    Patent number: 7868138
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: January 11, 2011
    Assignee: Codexis, Inc.
    Inventors: Willem P. C. Stemmer, Andreas Crameri
  • Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
    Publication number: 20100331193
    Abstract: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
    Type: Application
    Filed: September 11, 2009
    Publication date: December 30, 2010
    Applicant: Maxygen, Inc.
    Inventors: Willem P.C. Stemmer, Andreas Crameri