Abstract: The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, leading to modulation of the expression of HTRA1. Modulation of HTRA1 expression is beneficial for a range of medical disorders, such as macular degeneration, e.g. age-related macular degeneration.

Abstract: The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, leading to modulation of the expression of HTRA1. Modulation of HTRA1 expression is beneficial for a range of medical disorders, such as macular degeneration, e.g. age-related macular degeneration.

Abstract: The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, leading to modulation of the expression of HTRA1. Modulation of HTRA1 expression is beneficial for a range of medical disorders, such as macular degeneration, e.g. age-related macular degeneration.

Abstract: The differentiation between ulcerative colitis and Crohn's disease is made possible by a multi-gene approach where gene expression profiles in biopsy samples obtained from inflamed, and optionally also non-inflamed, areas in the intestines of a patient are studied.

Abstract: The differentiation between ulcerative colitis and Crohn's disease is made possible by a multi-gene approach where gene expression profiles in biopsy samples obtained from inflamed, and optionally also non-inflamed, areas in the intestines of a patient are studied.

Abstract: The differentiation between ulcerative colitis and Crohn's disease is made possible by a multi-gene approach where gene expression profiles in biopsy samples obtained from inflamed, and optionally also non-inflamed, areas in the intestines of a patient are studied.

Abstract: The present invention relates antisense oligonucleotide compounds for use in modulating the function of nucleic acid molecules encoding neutrophil gelatinase associated lipocalin (NGAL). More specifically, the invention provides compounds of 8 to 50 nucleobases in length capable of specifically hybridising with nucleic acid molecules encoding NGAL and thereby inhibiting the expression of the NGAL protein product, as well as pharmaceutical compositions thereof and methods of their use.

Abstract: The present invention relates antisense oligonucleotide compounds for use in modulating the function of nucleic acid molecules encoding mammalian MMP-12. More specifically, the invention provides compounds of 8 to 50 nucleobases in length capable of specifically hybridising with nucleic acid molecules encoding MMP-12 and thereby inhibiting the expression of the MMP-12 protein product, as well as pharmaceutical compositions thereof and methods of its use.

Abstract: An emergency support member is provided for a vehicle wheel and tire assembly having a pneumatic tire that is mounted on a wheel rim. The support member is embodied as a dished annular member within the tire, and has an emergency support surface for supporting the tire in the event of damage thereto. The annular member extends axially from the center of the rim and symmetrically over a portion of the width thereof. The annular member has a curved contour, with the two axially outer wall regions being supported upon the wheel rim via annular support elements. The dished annular member is embodied as a split ring that is not closed over its periphery, and is provided with a closure device for closing off the slit. The closure device includes two flanges that extend essentially radially inwardly relative to the rim. The closure device also includes at least one locking clamp for connecting the flanges.

Abstract: Vehicle wheel includes a rim and a pneumatic tire which includes a tread, two side walls, a carcass, reinforcing elements, and two tire beads with bead cores. An emergency running support body is supported on the rim which is arranged to support one of the pneumatic tire and an interior of the tread in an event of an emergency condition. The emergency running support body includes a shell-shaped ring body located inside the pneumatic tire and an emergency running surface on its exterior. At least one container, which contains a lubricant, is positioned inside a first ring chamber. This Abstract is not intended to define the invention disclosed in the specification , nor intended to limit the scope of the invention in any way.

Abstract: Motor vehicle wheel having a tire mounted on a rim and method of making the same. The wheel includes a ring made of a sound-absorbing material positioned inside the interior of the tire and encircling the rim. Threads are arranged to cover the ring to fix the ring to the rim. The threads are stretched over both sides of the ring one of towards or onto the rim. The method includes positioning the ring made of sound-absorbing material onto a circumferential area of the rim and stretching threads over the ring made of sound-absorbing material one of toward and onto the rim.

Abstract: An emergency support member is provided for a vehicle wheel and tire assembly having a pneumatic tire that is mounted on a wheel rim. The support member is embodied as a dished annular member within the tire, and has an emergency support surface for supporting the tire in the event of damage thereto. The annular member extends axially from the center of the rim and symmetrically over a portion of the width thereof. The annular member has a curved contour, with the two axially outer wall regions being supported upon the wheel rim via annular support elements. The dished annular member is embodied as a split ring that is not closed over its periphery, and is provided with a closure device for closing off the slit. The closure device includes two flanges that extend essentially radially inwardly relative to the rim. The closure device also includes at least one locking clamp for connecting the flanges.

Abstract: A method for testing bus connections of electronic circuits, in particular memory components, selects address and data bit test patterns such that, in a first step of write and read steps, respectively, the bits in the address bit test pattern have a first binary value and, in the first step of write steps, the bits in the data bit test pattern have a second value and, for each following step, starting with the lowest-value or highest-value bit, the respective adjacent bit is assigned a binary value which is complementary to that in the preceding step until, in the final step, all the bits in the address or data bit test pattern have a complementary value.