Abstract: The present disclosure provides methods and intermediates for making Compound A or a pharmaceutical salt thereof, and/or a solvate of, which are useful as methods and intermediates for producing compounds for treating diseases and conditions related to mutant KIT and PDGFRA.

Abstract: A handle for an oral-care implement for safe and hygienic use by multiple users includes an electrical motor and a detachable head. The handle has a display for displaying instructions to control functional operation of the handle, a microcontroller for controlling the motor and the display, and at least one switch to allow a user to control the functional operation of the handle, including causing the output element to vibrate in at least one oral-hygiene mode having an oral-hygiene frequency and causing the output element to vibrate in a disinfection mode when the handle is being disinfected before or after being used for the oral-hygiene routine. The disinfection mode has a modulated frequency, different from the oral-hygiene frequency, and alternating up and down between a low modulated frequency and a high modulated frequency, wherein the high modulated frequency is at least 50 percent greater than the low modulated frequency.

Abstract: Various embodiments of the teachings herein include a method for electrically charging vehicle batteries for a group of member vehicles. The method may include: predicting a total energy requirement for charging batteries for the group in a future time period; predicting a temporal distribution of the charging power requirement for the group over the future time period; calculating a total charging power profile optimized in respect of one or more optimization criteria according to the predicted total energy requirement and the predicted temporal distribution of the charging power requirement; purchasing an amount of energy in accordance with the optimized total charging power profile on a relevant energy market; and chronometrically controlling the charging processes of each member vehicle with a respective charging profile so the sum of the respective charging profiles of the individual member vehicles corresponds to the optimized total profile of the charging power.

Abstract: A sensor system is adapted for use with an article of footwear and includes an insert member including a first layer and a second layer, a port connected to the insert and configured for communication with an electronic module, a plurality of force and/or pressure sensors on the insert member, and a plurality of leads connecting the sensors to the port.

Abstract: A sensor system is adapted for use with an article of footwear and includes an insert member including a first layer and a second layer, a port connected to the insert and configured for communication with an electronic module, a plurality of force and/or pressure sensors on the insert member, and a plurality of leads connecting the sensors to the port.

Abstract: The present invention relates to a highly efficient method for producing oil-in-water emulsions, preferably for parenteral administration, which method is characterized in that large parts of the water phase are added only after the energy-intensive homogenization of the pre-emulsion, i.e. an emulsion having low water content is first produced and said emulsion is subsequently “diluted”.

Abstract: In a method for predicting future driving conditions for a vehicle (1), sensor data (2) are gathered while the vehicle (1) is traveling on a route. A position of the vehicle (1) is also determined. The gathered data are associated with the determined vehicle position. A map (9) is created depending on the associated data. When the route is traveled again, the map is updated in real time depending on associated data from the repeated traveling. Finally, a prediction of future driving conditions is obtained based on the determined vehicle position and the map (9).

Abstract: In a method for predicting future driving conditions for a vehicle (1), sensor data (2) are gathered while the vehicle (1) is traveling on a route. A position of the vehicle (1) is also determined. The gathered data are associated with the determined vehicle position. A map (9) is created depending on the associated data. When the route is traveled again, the map is updated in real time depending on associated data from the repeated traveling. Finally, a prediction of future driving conditions is obtained based on the determined vehicle position and the map (9).

Abstract: A data memory, a computing unit and a method for performing a function of a vehicle are described, wherein values of an item of information relating to predefined local areas of a digital map are taken into account when the function is performed, the values of the information being stored in the form of an expected value and a distribution of the values around the expected value.

Abstract: A sensor system is adapted for use with an article of footwear and includes an insert member including a first layer and a second layer, a port connected to the insert and configured for communication with an electronic module, a plurality of force and/or pressure sensors on the insert member, and a plurality of leads connecting the sensors to the port.

Abstract: A sensor system is adapted for use with an article of footwear and includes an insert member including a first layer and a second layer, a port connected to the insert and configured for communication with an electronic module, a plurality of force and/or pressure sensors on the insert member, and a plurality of leads connecting the sensors to the port.

Abstract: This invention relates to peptide-exchange proteins comprising the luminal domain of TAP-binding protein-related (TAPBPR), which functions as a MHC class I peptide-exchange catalyst when presented to mammalian cells either as a soluble extracellular protein or as a membrane bound cell surface protein. This may be useful in modulating immune responses, including for example loading immunogenic peptide onto tumours or other disease cells to induce their recognition by T cells. Peptide-exchange proteins and methods for their use are provided.