Abstract: A wheel of a vehicle, in particular a motor vehicle, has a rim, a hub portion, and at least two spokes connecting the hub portion to the rim. At least one free space between the spokes is covered at least in part by a substantially planar covering element. The covering element is produced from two different material layers.

Abstract: The present invention relates to polysaccharide soft tissue fillers comprising heparosan and processes for their preparation. The polysaccharide soft tissue fillers of the present invention are advantageously used in therapeutic or cosmetic applications such as for the filling of wrinkles.

Abstract: The present invention generally relates to a modified hyaluronic acid (HA) and to a method for making same, more specifically to a (poly)glycerol-modified HA derivative prepared by grafting glycidol to HA. The present invention also relates to the use of the HA derivative for preparing a dermal filler composition, a hydrogel comprising cross-linked HA and the (poly)glycerol-modified HA derivative, and a method for preparing said hydrogel. Furthermore, the present invention relates to the use of the hydrogel as a cosmetic and/or aesthetic product, in particular as a dermal filler for tissue filling, replacing and/or augmenting.

Abstract: The present invention relates to a dosing regimen for (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one.

Abstract: A bicycle saddle includes a saddle shell and a saddle cushion being connected with the top surface thereof. Further, a saddle frame is provided, having a front end connected with the saddle shell in a region of a saddle tip. A holding element is connected with a rear end of the saddle frame. A damper element is arranged between the holding element and a lower side of the saddle shell, the damper element being in surface connection with the lower side.

Abstract: Systems and methods for the crowdsourced clustering of data items in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining categories for a set of source data includes obtaining a set of source data, determining a plurality of subsets of the source data, where a subset of the source data includes a plurality of pieces of source data in the set of source data, generating a set of pairwise annotations for the pieces of source data in each subset of source data, clustering the set of source data into related subsets of source data based on the sets of pairwise labels for each subset of source data, and identifying a category for each related subset of source data based on the clusterings of source data and the source data metadata for the pieces of source data in the group of source data.

Abstract: A downhill grip for a bicycle comprises an inner sleeve. The inner sleeve is enclosed by a grip element. For fixing the downhill bicycle grip to a bicycle handlebar, a fixing element is connectible to the inner sleeve. The grip element has a larger circumference in an outer region than at in an inner region.

Abstract: The present invention relates to a sterile in situ cross-linkable polysaccharide compositions for augmenting, filling or replacing soft tissues in various cosmetic and therapeutic applications. The composition comprises a first polysaccharide derivative functionalized with a nucleophilic group and a second polysaccharide derivative functionalized with an electrophilic group. Said nucleophilic and electrophilic functional groups spontaneously form in situ covalent linkages following co-injection in the body of a patient, resulting in the formation of a cross-linked hydrogel at the site of co-injection.

Abstract: The present invention relates to a process for depleting epoxide species in epoxy-crosslinked polysaccharide gel compositions. In addition, the present invention relates to crosslinked polysaccharide gel compositions made by said process and their use in cosmetic and therapeutic applications.

Abstract: A method for producing a lignocellulose plastic composite material, in particular a simpler and more cost-effective option for producing lignocellulose plastic composite materials. Thermoplastic particles and a mixture of water and lignocellulose-containing particles are supplied to a refiner, and the lignocellulose-containing particles are reduced to fibres in the refiner. The thermoplastic particles are supplied to the refiner in a melted or fused state, or are melted or fused in the refiner, so that the melted or fused thermoplastic particles and the lignocellulose-containing particles that are reduced to fibres form material composite particles in the refiner.

Abstract: A bicycle saddle comprises a saddle shell. A seat cushion is arranged on an upper side of the saddle shell. A support element that is connected to a saddle frame is also provided. An elastomer body is arranged between the saddle shell and the support element in order to decouple the saddle shell from the support element.

Abstract: The present invention relates to a dosing regimen for (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one.

Abstract: A bicycle handle has an inner sleeve surrounded by a handle element. In a clamping region, the inner sleeve is surrounded by a clamping element, in particular in a clip-like manner. The clamping element is at least partly surrounded by a protective sleeve, wherein it is preferred that the protective sleeve is surrounded with softer material, in particular the material of the handle element.

Abstract: The present invention relates to a fuel pump for pumping fuel, comprising a piston (2) and a diaphragm seal element (3), which seals on an inner annular seal seat (4) and an outer annular seal seat (5), wherein the following equation is satisfied: (Ra2?ra2)/(ri+L)2=ra/ri, where ri is the inner radius of the inner seal seat (4), ra is the inner radius of the outer seal seat (5), Ra is the outer diameter of the piston (2) and L is a difference between an outer radius (Ria) of the inner seal seat (4) and the inner radius (ri) of the inner seal seat (4). The invention further relates to a method for operating a fuel pump.

Abstract: The present invention relates to a dosing regimen for (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one.

Abstract: A downhill grip for a bicycle comprises an inner sleeve. The inner sleeve is enclosed by a grip element. For fixing the downhill bicycle grip to a bicycle handlebar, a fixing element is connectible to the inner sleeve. The grip element has a larger circumference in an outer region than at in an inner region.