Patents by Inventor Andreas Linkwitz

Andreas Linkwitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulation for electrically assisted delivery of lidocaine and epinephrine
    Patent number: 6295469
    Abstract: The invention relates to formulations for the electrically assisted transdermal delivery of lidocaine and epinephrine. The present invention further provides methods and devices for the electrically assisted delivery of local anesthetics, preferably lidocaine.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: September 25, 2001
    Assignee: Alza Corporation
    Inventors: Andreas Linkwitz, Ivan W. Chin, J. Richard Gyory, Ronald V. Thompson, Paul J. Urbanski
  • Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
    Patent number: 5318558
    Abstract: A drug delivery capsule from which the delivery of the drug is driven by the osmotic infusion of moisture by the capsule from a physiological environment is provided with a delivery orifice which opens intermittently to achieve a pulsatile delivery effect. The wall in which the orifice is formed is constructed of an elastic material, preferably an elastomer, which stretches under a pressure differential caused by the pressure rise inside the capsule as the osmotic infusion progresses. The orifice is small enough that when the elastic wall is relaxed, the flow rate of drug through the orifice is substantially zero, but that when the elastic wall is stretched due to the pressure differential across the wall exceeding a threshold, the orifice expands sufficiently to allow the release of the drug at a physiologically beneficial rate.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: June 7, 1994
    Assignee: ALZA Corporation
    Inventors: Andreas Linkwitz, Judy A. Magruder, Sonya Merrill
  • Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
    Patent number: 5221278
    Abstract: A drug delivery capsule from which the delivery of the drug is driven by the osmotic infusion of moisture by the capsule from a physiological environment is provided with a delivery orifice which opens intermittently to achieve a pulsatile delivery effect. The wall in which the orifice is formed is constructed of an elastic material, preferably an elastomer, which stretches under a pressure differential caused by the pressure rise inside the capsule as the osmotic infusion progresses. The orifice is small enough that when the elastic wall is relaxed, the flow rate of drug through the orifice is substantially zero, but that when the elastic wall is stretched due to the pressure differential across the wall exceeding a threshold, the orifice expands sufficiently to allow the release of the drug at a physiologically beneficial rate.
    Type: Grant
    Filed: March 12, 1992
    Date of Patent: June 22, 1993
    Assignee: Alza Corporation
    Inventors: Andreas Linkwitz, Judy A. Magruder, Sonya Merrill