Abstract: The present disclosure relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations within the bioprocessing system (80), the bioprocessing system (80) comprising: a base unit (60) comprising a plurality of valve actuators, wherein at least one of the plurality of valve actuators is configured to releasably engage with a membrane valve cassette (200, 300, 400) that is removably attachable to the base unit (60), and wherein the at least one of the plurality of valve actuators is actuatable to regulate fluid flow through the membrane valve cassette (200, 300, 400); and a control system (20) operable to selectively actuate respective ones of the plurality of valve actuators to provide a valve configuration within the membrane valve cassette (200, 300, 400) to enable the base unit (60) and the membrane valve cassette (200, 300, 400) together to perform one of the predetermined set of bioprocessing operations.

Abstract: The present invention relates to a reconfigurable bioprocessing system (80) operable to perform a predetermined set of bioprocessing operations therein. The reconfigurable bioprocessing system (80) comprises a base unit (60) comprising a plurality of valve actuators (102). At least one of the plurality of valve actuators (102) is operable to releasably engage with at least part of a pinch valve cassette (103, 203) to control fluid flow through the pinch valve cassette (103, 203). At least part of the pinch valve cassette (103, 203) is removably attachable to the base unit (60) and the pinch valve cassette (103, 203) is provided adjacent to said plurality of valve actuators (102).

Abstract: The present invention relates to a method of case hardening a Group IV metal or a Group IV metal alloy and to components hardened in the method. The method comprising the steps of: providing a workpiece of a Group IV metal or a Group IV metal alloy, the workpiece being in its final shape; nitriding the workpiece in a nitriding atmosphere comprising NHs as a nitriding species at a first temperature in the range of 450° C. to 750° C. for a nitriding duration of at least 16 hours to provide a hydrogen containing diffusion zone; removing hydrogen from the hydrogen containing diffusion zone at a second temperature of up to 750° C. and a partial pressure of H2 of up to 10?4 mbar over a hydrogen removal duration of at least 4 hours to provide a hydrogen depleted diffusion zone. The method and the component are useful for implants, in particular dental implants.

Abstract: A diapharagm pump for a bioprocess system comprises a pump head (1; 101; 201; 301) comprising: a common inlet (3); a common outlet (5); a plurality of pump cavities (7) each including at least one cooperating pair of one-way valves, the at least one pair of one-way valves including an inlet valve (9) and an outlet valve (11), wherein the respective inlet valves (9) are in fluid communication with the common inlet (3) and the respective outlet valves (11) are in fluid communication with the common outlet (5) and wherein a centre of the outlet valve (11) for each pump cavity is positionable above a centre of the inlet valve (9) for the same pump cavity when the diaphragm pump is oriented for use to inhibit trapped gas; and a plurality of moveable diaphragms (13) each respectively provided in a respective of said pump cavities (7) for varying a volume of the pump cavities.

Abstract: A flow distribution device for bioprocess systems, comprising: a flow distribution manifold (12; 112) comprising: at least four fluid connection conduits (14), wherein each fluid connection conduit (14) comprises a first end (18) for fluid connection and an opposite second end (20), and wherein at least three of the fluid connection conduits comprise a membrane (19a) and a valve seat (19b), which membrane (19a) can be put in at least two different positions in relation to the valve seat (19b) for allowing or preventing fluid flow between the first end (18) and the second end (20) of the fluid connection conduit (14); and a central common compartment (30) to which the second ends (20) of each of the fluid connection conduits (14) are connected, whereby the first ends (18) of each of the fluid connection conduits (14) can be in fluid communication with the central common compartment (30) and wherein the fluid connection conduits (14) are entering the central common compartment (30) from at least three different

Abstract: A flow distribution device for bioprocess systems, comprising: ?—a flow distribution manifold (12; 112; 212; 312) comprising: ?o at least four fluid connection tubes (14), wherein each fluid connection tube (14) comprises a first end (18) for fluid connection and an opposite second end (20) ?o a central common compartment (30; 130; 230; 330) to which the second ends (20) of each of the fluid connection tubes (14) are connected, whereby the first ends (18) of each of the fluid connection tubes (14) can be in fluid communication with the central common compartment (30; 130; 230; 330) ?—at least three pinching members (41) which are provided in connection with one fluid connection tube (14) of the flow distribution manifold (12; 112; 212; 312) each, wherein each of said pinching members (41) can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members (41) the pinching member pinches one of the fluid connection tubes (14) such that fluid flow is pr

Abstract: A bandage for fixation of a limb is disclosed, the bandage comprising at least one flexible, thermoplastic polymer splint which is shaped and in plasticized condition attached to the surface of a longitudinal strip of fabric which is elastic in its length direction, the fabric and splint having a length sufficient for wrapping in layers about a limb. The splint is formed to the shape of a wave wherein adjacent splint ribs are interconnected at a wave crest or a wave trough respectively, wherein at least one of the wave crests and the wave troughs is located near, i.e. in the region of, a longitudinal edge of the strip of fabric. A method for manufacture of the splint-armored bandage is likewise disclosed.

Abstract: A connection device (1; 101) configured for connecting a separation system (3) with a separation device (5), wherein a fluid can be flowed from a separation system outlet connection (19), through a bypass fluid path (27) of the connection device to the separation system inlet connection (15) while a connected separation device (5) is by passed. For achieving this at least one of an inlet and an outlet valve (31, 33) provided in the connection device is provided in a closed state and at least one bypass valve (35, 35a, 35b) provided in the connection device is provided in an open state.

Abstract: A chromatography column comprises a tubular member (1) having an open inlet end and an outlet end and being adapted to receive a packing material, and an end piece (2) inserted through the inlet end of the tubular member (1). The end piece (2) comprises a generally planar inner end portion 4, and a rounded outer end portion (5), adapted to accommodate pressure forces acting on the inner end. The end piece (2) is fixed to the inner surface of the tubular member (1) by a weld- or bond-forming joining technique based on non-contact energy transfer, preferably laser welding. A method for manufacturing a pre-packed chromatography column is also disclosed.

Abstract: A chromatography column comprises a tubular member (1) having an open inlet end and an outlet end and being adapted to receive a packing material, and an end piece (2) inserted through the inlet end of the tubular member (1). The end piece (2) comprises a generally planar inner end portion 4, and a rounded outer end portion (5), adapted to accommodate pressure forces acting on the inner end. The end piece (2) is fixed to the inner surface of the tubular member (1) by a weld- or bond-forming joining technique based on non-contact energy transfer, preferably laser welding. A method for manufacturing a pre-packed chromatography column is also disclosed.