Abstract: To simplify the optical calibration of an optical observation apparatus, a stand for an optical observation unit including a calibration object arranged directly on the stand in a fixed location is specified. Moreover, an optical observation apparatus, which includes such a stand and an optical observation unit connected to the stand, a method for calibrating such an optical observation apparatus, and a computer program are specified.

Abstract: According to one aspect, a vehicle safety system includes an actuatable controlled restraint (ACR) comprising a seatbelt for restraining a vehicle occupant. The ACR is actuatable to control payout and retraction of the seatbelt. The system also includes a controller configured to determine operating conditions of the vehicle and to control the actuation of the ACR in response to the determined operating conditions of the vehicle. The ACR has a normal restraint condition and an enhanced restraint condition, the controller being configured to actuate the ACR from the normal restraint condition to the enhanced restraint condition in response to determining abnormal driving conditions of the vehicle.

Abstract: The present disclosure relates to a telecommunication method for monitoring with a mobile end user telecommunication device a telecommunication process on a digital telecommunication system using a telecommunication process monitoring server. The telecommunication process monitoring server is connectable with the mobile end user telecommunication device via a mobile wireless cellular digital telecommunication network. The telecommunication process monitoring server further is connectable with a real-time database. The digital telecommunication system further comprising a plurality of second telecommunication devices being connectable with the telecommunication control server via one or more second digital telecommunication networks. The telecommunication process comprises sending one or more telecommunication messages to the plurality of second telecommunication devices.

Abstract: A through-type furnace for substrates comprises a furnace with a channel and a transport system for the transport of the substrates through the channel. The channel is bounded by a base, a front side wall, a rear side wall and a top part. The base contains a plurality of first holes which are connectable to a protective gas source so that protective gas can be supplied during operation. The front side wall of the channel comprises a longitudinal slit which extends parallel to the passage direction and which is bounded by a bottom edge and an upper edge. The transport system comprises at least one clamp for transporting the substrates through the channel. The clamp is movable back and forth along the longitudinal slit of the channel. Such a through-type furnace is in particular suitable for use in a soft solder die bonder.

Abstract: The present disclosure relates to a telecommunication method for monitoring with a mobile end user telecommunication device a telecommunication process on a digital telecommunication system using a telecommunication process monitoring server. The telecommunication process monitoring server is connectable with the mobile end user telecommunication device via a mobile wireless cellular digital telecommunication network. The telecommunication process monitoring server further is connectable with a real-time database. The digital telecommunication system further comprising a plurality of second telecommunication devices being connectable with the telecommunication control server via one or more second digital telecommunication networks. The telecommunication process comprises sending one or more telecommunication messages to the plurality of second telecommunication devices.

Abstract: A through-type furnace for substrates comprises a furnace with a channel and a transport system for the transport of the substrates through the channel. The channel is bounded by a base, a front side wall, a rear side wall and a top part. The base contains a plurality of first holes which are connectable to a protective gas source so that protective gas can be supplied during operation. The front side wall of the channel comprises a longitudinal slit which extends parallel to the passage direction and which is bounded by a bottom edge and an upper edge. The transport system comprises at least one clamp for transporting the substrates through the channel. The clamp is movable back and forth along the longitudinal slit of the channel. Such a through-type furnace is in particular suitable for use in a soft solder die bonder.

Abstract: A discovery process beginning with an in vivo screening of proteins, peptides, natural products, classical medicinal compound or other substances. The administration of compounds to the animal can be either direct or indirect, such as by the administration and expression of cDNA-containing plasmids. Since the discovery process of the invention is based on a non-preconceived hypothesis and whole organism multi-organ analysis, a compound can be selected for testing in the absence of any biological selection criteria. The resulting organism-wide pattern of the gene expression changes in the transcriptome provides an overview of the activities at the molecular and organism-wide levels. The discovery process of the invention then integrates in vivo profiling and internal and external genomic databases to elucidate the function of unknown proteins.

Abstract: A method of determining the acute allograft rejection status of a subject, the method comprising the steps of: determining the nucleic acid expression profile of one or more than one nucleic acid markers, or one or more than one proteomic markers in a biological sample from the subject; comparing the expression profile of the one or more than one nucleic acid markers to a control profile; and determining whether the expression level of the one or more than one nucleic acid markers is increased relative to the control profile, wherein the increase of the one or more than one nucleic acid markers is indicative of the acute rejection status of the subject.

Abstract: The invention relates to the analysis and identification of genes that are modulated in transplant rejection. This alteration of gene expression provides a molecular signature to accurately detect transplant rejection.

Abstract: A discovery process beginning with an in vivo screening of proteins, peptides, natural products, classical medicinal compound or other substances. The administration of compounds to the animal can be either direct or indirect, such as by the administration and expression of cDNA-containing plasmids. Since the discovery process of the invention is based on a non-preconceived hypothesis and whole organism multi-organ analysis, a compound can be selected for testing in the absence of any biological selection criteria. The resulting organism-wide pattern of the gene expression changes in the transcriptome provides an overview of the activities at the molecular and organism-wide levels. The discovery process of the invention then integrates in vivo profiling and internal and external genomic databases to elucidate the function of unknown proteins, typically within few months.

Abstract: A peptide of phospholipase A2 had been detected in human plasma and synthesised. The peptide was injected into mice and gene expression profiling on many organs performed. Phospholipase A2 showed significant effects on regulation of gene expression in the liver. The genes affected are members of the integrin signalling pathway, wnt pathway and PTEN pathway. The changes in gene expression indicate a positive effect of phospholipase A2 on cell proliferation and invasiveness. The gene annotation points at colorectal cancer.

Abstract: Methods are disclosed for, early diagnosing chronic rejection (CR) in a transplanted subject, monitoring CR in a transplanted subject at risk of developing CR, preventing, inhibiting, reducing or treating CR in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of CR, based on genes which are differentially expressed in transplant biopsy tissues, before any overt clinical or histological manifestation of CR is detected in the transplanted subject.