Patents by Inventor Andreas Schirbel

Andreas Schirbel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9814789
    Abstract: A radiopharmaceutical composition is disclosed comprising novel iodometomidate derivatives of formula (I) which bind specifically to adrenal enzymes and which exhibit an improved stability. The compounds of formula (I) are suitable for use in a diagnostic imaging method, e.g. for diagnosis of adrenocortical carcinoma. The compounds of formula (I) are further suitable for use in the treatment of adrenocortical carcinoma, by means of radionuclide therapy.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: November 14, 2017
    Assignee: Julius-Maximilians-Universität Würzburg
    Inventors: Bruno Allolio, Andreas Schirbel, Stefanie Hahner
  • Publication number: 20150328341
    Abstract: A radiopharmaceutical composition is disclosed comprising novel iodometomidate derivatives of formula (I) which bind specifically to adrenal enzymes and which exhibit an improved stability. The compounds of formula (I) are suitable for use in a diagnostic imaging method, e.g. for diagnosis of adrenocortical carcinoma. The compounds of formula (I) are further suitable for use in the treatment of adrenocortical carcinoma, by means of radionuclide therapy.
    Type: Application
    Filed: September 26, 2013
    Publication date: November 19, 2015
    Applicant: Julius-Maximillians-Universitat Wurzburg
    Inventors: Bruno Allolio, Andreas Schirbel, Stefanie Hahner
  • Publication number: 20130089502
    Abstract: A functional PET imaging method is disclosed for differentiation between bilateral hyperplasia and unilateral adenoma comprising (1) introducing a radioactively labelled CYP11 B2 (aldosterone synthase) inhibitor which binds selectively to CYP11 B2 (aldosterone synthase) relative to CYP11 B1 (11?-hydroxylase) into a mammal with adrenal glands and (2) conducting positron emission tomography (PET) in the region of the adrenal glands to obtain a functional PET image of the adrenal glands. Also disclosed are radioactive tracer compounds suitable for use in this method, precursors for making the same, and a process for making the radioactive tracer compounds capable of being conducted as a rapid one-pot reaction.
    Type: Application
    Filed: June 1, 2011
    Publication date: April 11, 2013
    Applicants: UNIVERSITAT DES SAARLANDES, JULIUS-MAXIMILIANS-UNIVERSITAT
    Inventors: Bruno Allolio, Stefanie Hahner, Andreas Schirbel, Rolf Hartmann, Christina Zimmer