Patents by Inventor Andrei Kovalenko

Andrei Kovalenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical Compositions and Diagnostic Methods for Inflammatory Skin Diseases, Disorders or Conditions
    Publication number: 20150329867
    Abstract: The invention relates to the treatment or prevention of an inflammatory skin disease, disorder or condition, by modulating a protein that is normally regulated by caspase-8 in the skin or by increasing caspase-8 activity or level in the skin. Another aspect of the invention relates to methods for diagnosing an inflammatory skin disease, disorder or condition or a predisposition to develop said disease disorder or condition in an individual. Further aspects of the invention relate to methods for identifying target proteins involved in the course or pathology of an inflammatory skin disease, disorder or condition and to methods of screening a candidate compound for treating said disease, disorder or condition. In particular, the invention relates to inflammatory skin diseases such as atopic dermatitis and psoriasis.
    Type: Application
    Filed: July 2, 2015
    Publication date: November 19, 2015
    Inventors: David WALLACH, Andrei KOVALENKO, Tae-Bong KANG, Jin Chul KIM
  • SIVA 3, its preparation and use
    Patent number: 8377433
    Abstract: The present invention relates to a splice variant of SIVA, SIVA3, and to its use.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: February 19, 2013
    Assignee: Yeda Research and Development Co., Inc., Weizmann Institute of Science.
    Inventors: David Wallach, Parameswaran Ramakrishnan, Andrei Kovalenko
  • Method of treating a disease by administering caspase-8
    Patent number: 8318660
    Abstract: The invention relates to caspases and to extracellular use of caspases for regulating cell functions.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: November 27, 2012
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Elena Appel, Andrei Kovalenko, Rajput Akhill
  • SIVA ubiquitination and/or degradation-related activity and modulators thereof
    Patent number: 8273545
    Abstract: The present invention relates to the ubiquitination and/or degradation-related activity of a SIVA polypeptide and to agents capable of modulating said activity.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: September 25, 2012
    Assignees: Yeda Research and Development Co. Ltd, Weizmann Institute of Science
    Inventors: David Wallach, Parameswaran Ramakrishnan, Wang Wangxia, Andrei Kovalenko
  • Modulators of TNF receptor associated factor (TRAF), their preparation and use
    Patent number: 8236507
    Abstract: A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: August 7, 2012
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Nikolai Malinin, Mark Boldin, Andrei Kovalenko, Igor Mett
  • CASPASE-8 AND SKIN DISEASE
    Publication number: 20120144504
    Abstract: The invention relates to the treatment or prevention of an inflammatory skin disease, disorder or condition, by modulating a protein that is normally regulated by caspase-8 in the skin or by increasing caspase-8 activity or level in the skin. Another aspect of the invention relates to methods for diagnosing an inflammatory skin disease, disorder or condition or a predisposition to develop said disease disorder or condition in an individual. Further aspects of the invention relate to methods for identifying target proteins involved in the course or pathology of an inflammatory skin disease, disorder or condition and to methods of screening a candidate compound for treating said disease, disorder or condition. In particular, the invention relates to inflammatory skin diseases such as atopic dermatitis and psoriasis.
    Type: Application
    Filed: October 16, 2006
    Publication date: June 7, 2012
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Andrei Kovalenko, Tae-Bong Kang, Jin Chul Kim
  • SIVA 2 STABILIZATION
    Publication number: 20110293593
    Abstract: The present invention relates to modulation of SIVA2 stability by N-acetylglucosamine, phosphorylation of ubiquitination in treatment or prevention of diseases, disorders or conditions.
    Type: Application
    Filed: February 11, 2009
    Publication date: December 1, 2011
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: David Wallach, Parameswaran Ramakrishnan, Andrei Kovalenko
  • SIVA 3, ITS PREPARATION AND USE
    Publication number: 20110035817
    Abstract: The present invention relates to a splice variant of SIVA, SIVA3, and to its use.
    Type: Application
    Filed: February 9, 2009
    Publication date: February 10, 2011
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: David Wallach, Parameswaran Ramakrishnan, Andrei Kovalenko
  • SIVA Ubiquitination and/or Degradation-Related Activity and Modulators Thereof
    Publication number: 20100204091
    Abstract: The present invention relates to the ubiquitination and/or degradation-related activity of a SIVA polypeptide and to agents capable of modulating said activity.
    Type: Application
    Filed: January 11, 2007
    Publication date: August 12, 2010
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: David Wallach, Parameswaran Ramakrishnan, Wang Wangxia, Andrei Kovalenko
  • Inhibitor of NF-KB activation
    Patent number: 7745579
    Abstract: The present invention relates to a protein, designated NAP (Nemo Associated Protein), that was discovered to inhibit the activation of transcription factor NF-kB by various signals that are important in inflammatory and immune processes. The DNA and the recombinant production of this protein is also disclosed as well as methods of using the protein or encoding DNA.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: June 29, 2010
    Inventors: David Wallach, Andrei Kovalenko, Giuseppina Cantarella
  • MODULATORS OF TNF RECEPTOR ASSOCIATED FACTOR (TRAF), THEIR PREPARATION AND USE
    Publication number: 20090291888
    Abstract: A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
    Type: Application
    Filed: February 3, 2009
    Publication date: November 26, 2009
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: David Wallach, Nikolai Malinin, Mark Boldin, Andrei Kovalenko, Igor Mett
  • USE OF CASPASES FOR THE PREPARATION OF MEDICAMENTS
    Publication number: 20090104175
    Abstract: The invention relates to caspases and to extracellular use of caspases for regulating cell functions.
    Type: Application
    Filed: March 3, 2007
    Publication date: April 23, 2009
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: David Wallach, Elena Appel, Andrei Kovalenko, Rajput Akhil
  • Modulators of TNF receptor associated factor (TRAF), their preparation and use
    Patent number: 7485456
    Abstract: A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: February 3, 2009
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Nikolai Malinin, Mark Boldin, Andrei Kovalenko, Igor Mett
  • CASH (Caspase Homologue) with death effector domain, modulators of the function of FAS
    Patent number: 7419804
    Abstract: Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: September 2, 2008
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Yura Goltsev, Andrei Kovalenko, Eugene Varfolomeev, Vadim Brodianski
  • Cash (caspase homologue) with death effector domain, modulators of the function of FAS receptors
    Patent number: 7407771
    Abstract: Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: August 5, 2008
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Yura Goltsev, Andrei Kovalenko, Eugene Varfolomeev, Vadim Brodianski
  • MODULATORS OF THE FUNCTIONS OF RECEPTORS OF THE TNF/NGF RECEPTOR FAMILY AND OTHER PROTEINS
    Publication number: 20080159986
    Abstract: Proteins which are capable of modulating/mediating the function of RIP, their preparation and uses are provided.
    Type: Application
    Filed: March 12, 2007
    Publication date: July 3, 2008
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: David Wallach, Andrei Kovalenko
  • Modulators of the function of receptors of the TNF/NGF receptor family and other proteins
    Patent number: 7189535
    Abstract: Proteins which are capable of modulating/mediating the function of RIP, their preparation and uses are provided.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: March 13, 2007
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Andrei Kovalenko
  • CASH (CASPASE HOMOLOGUE) with death effector domain, modulators of the function of FAS
    Publication number: 20060216788
    Abstract: Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use.
    Type: Application
    Filed: June 8, 2006
    Publication date: September 28, 2006
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: David Wallach, Yura Goltsev, Andrei Kovalenko, Eugene Vappolomeev, Vadim Brodianski
  • Modulators of the function of receptors of the TNF/NGF receptor family and other proteins
    Patent number: 7083788
    Abstract: Proteins which are capable of modulating/mediating the function of RIP, their preparation and uses are provided.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: August 1, 2006
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Andrei Kovalenko
  • CASH (CASPASE HOMOLOGUE) with death effector domain, modulators of the function of FAS receptors
    Publication number: 20050152877
    Abstract: Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as their use.
    Type: Application
    Filed: November 30, 2004
    Publication date: July 14, 2005
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: David Wallach, Yura Goltsev, Andrei Kovalenko, Eugene Varfolomeev, Vadim Brodianski