Patents by Inventor Andrei V. Gudkov

Andrei V. Gudkov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLAGELLIN-BASED AGENTS AND USES INCLUDING EFFECTIVE VACCINATION
    Publication number: 20170266278
    Abstract: The present invention relates to, in part, compositions comprising improved flagellin derived constructs and methods of using for vaccination, including adjuvants comprising flagellin-based agents.
    Type: Application
    Filed: July 30, 2015
    Publication date: September 21, 2017
    Inventors: Andrei V. GUDKOV, Vadim METT, Vadim KRIVOKRYSENKO
  • PROTECTION AGAINST APOPTOSIS FROM IONIZING RADIATION
    Publication number: 20170128533
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Application
    Filed: January 24, 2017
    Publication date: May 11, 2017
    Inventor: Andrei V. Gudkov
  • FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF
    Publication number: 20170080051
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Application
    Filed: September 1, 2016
    Publication date: March 23, 2017
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • Protection against apoptosis from ionizing radiation
    Patent number: 9585939
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: March 7, 2017
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Andrei V. Gudkov
  • Flagellin related polypeptides and uses thereof
    Patent number: 9457061
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: October 4, 2016
    Assignee: Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • INDUCTION OF CELLULAR SENESCENCE FOR TISSUE THERAPIES
    Publication number: 20160213714
    Abstract: Provided are compositions and methods for aiding in healing of a tissue wound in an individual. The method generally entail delivering to an individual in need thereof senescent cells such that healing of the wound is accelerated. The disclosure includes use of senescent cells and senescent tumor cells, either of which may be allogeneic or autologous to the individual. Also provided are methods for inducing senescence in cells and using the cells for wound healing, and articles of manufacture comprising senescent cells for use in wound healing.
    Type: Application
    Filed: January 25, 2016
    Publication date: July 28, 2016
    Inventors: Andrei V. Gudkov, Olga Chernova, Brandon Hall
  • MODULATING APOPTOSIS
    Publication number: 20160166644
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Application
    Filed: February 22, 2016
    Publication date: June 16, 2016
    Inventor: Andrei V. Gudkov
  • Modulating apoptosis
    Patent number: 9296793
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: March 29, 2016
    Assignee: The Cleveland Clinic Foundation
    Inventor: Andrei V. Gudkov
  • FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF
    Publication number: 20160082077
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 24, 2016
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • Flagellin related polypeptides and uses thereof
    Patent number: 9228000
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: January 5, 2016
    Assignee: Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF
    Publication number: 20150376241
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Application
    Filed: August 17, 2015
    Publication date: December 31, 2015
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • Viral vector encoding a toll-like receptor and encoding a toll-like receptor agonist
    Patent number: 9205095
    Abstract: The present invention is directed to methods and agents used for treating cancer or infectious diseases by providing toll-like receptors such as toll-like receptor 5 (TLR-5) in combination with providing a toll-like receptor agonists such as flagellin resulting in a cis and in-trans effect that recruits cells involved in both the innate (cis effect) and adaptive (trans effect) immune response to specifically kill cancer cells and cells infected with a pathogen via the NF-?B apoptosis pathway.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: December 8, 2015
    Assignee: Panacela Labs, LLC
    Inventor: Andrei V. Gudkov
  • Flagellin related polypeptides and uses thereof
    Patent number: 9139623
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: September 22, 2015
    Assignee: Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF
    Publication number: 20150203541
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptsis is described.
    Type: Application
    Filed: December 3, 2014
    Publication date: July 23, 2015
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • MODULATING APOPTOSIS
    Publication number: 20150072931
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Application
    Filed: June 16, 2014
    Publication date: March 12, 2015
    Inventor: Andrei V. Gudkov
  • Flagellin related polypeptides and uses thereof
    Patent number: 8932609
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: January 13, 2015
    Assignee: Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • Flagellin related polypeptides and uses thereof
    Patent number: 8871215
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptsis is described.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: October 28, 2014
    Assignee: Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF
    Publication number: 20140294900
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptsis is described.
    Type: Application
    Filed: May 21, 2014
    Publication date: October 2, 2014
    Applicant: Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • Method for screening modulators of apoptosis
    Patent number: 8784840
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: July 22, 2014
    Assignee: The Cleveland Clinic Foundation
    Inventor: Andrei V. Gudkov
  • Method of Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides
    Publication number: 20130324462
    Abstract: The use of flagellin and flagellin related polypeptides for reducing cancer treatment side effects in mammals is described.
    Type: Application
    Filed: March 26, 2013
    Publication date: December 5, 2013
    Inventors: Andrei V. Gudkov, Vadim Krivokrysenko, Lyudmila Burdelya