Patents by Inventor Andrej Tarkowski

Andrej Tarkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of microbial infections
    Patent number: 11512118
    Abstract: The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: November 29, 2022
    Assignee: THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
    Inventors: Timothy Foster, Judy Higgins, Elisabet Josefsson, Joan Geoghegan, Andrej Tarkowski
  • Methods for treating or reducing the risk of arthritis in a subject by administering gelsolin
    Patent number: 10238715
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: March 26, 2019
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Anna Charlotta Teresia Magnuson Osborn, Andrej Tarkowski
  • USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES
    Publication number: 20170281724
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Application
    Filed: April 18, 2016
    Publication date: October 5, 2017
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski
  • TREATMENT OF MICROBIAL INFECTIONS
    Publication number: 20170202943
    Abstract: The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 20, 2017
    Inventors: Timothy Foster, Judy Higgins, Elisabet Josefsson, Joan Geoghegan, Andrej Tarkowski
  • Treatment of microbial infections
    Patent number: 9637525
    Abstract: The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: May 2, 2017
    Assignee: THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH
    Inventors: Timothy Foster, Judy Higgins, Elisabet Josefsson, Joan Geoghegan, Andrej Tarkowski
  • USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES
    Publication number: 20160228505
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Application
    Filed: April 18, 2016
    Publication date: August 11, 2016
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski
  • Method of prophlactically treating infection using a recombinant fibrinogen binding protein clumping factor A (ClfA) or fragment thereof
    Patent number: 9353160
    Abstract: The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: May 31, 2016
    Assignees: GLAXOSMITHKLINE BIOLOGICALS S.A., THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
    Inventors: Timothy Foster, Judy Higgins, Elisabet Josefsson, Joan Geoghegan, Guy Dequesne, Andrej Tarkowski, Carlake Andersson
  • TREATMENT OF MICROBIAL INFECTIONS
    Publication number: 20150232518
    Abstract: The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Inventors: Timothy Foster, Judy Higgins, Elisabet Josefsson, Joan Geoghegan, Andrej Tarkowski
  • TREATMENT OF INFECTIONS
    Publication number: 20120244189
    Abstract: The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
    Type: Application
    Filed: July 16, 2010
    Publication date: September 27, 2012
    Applicants: THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF, GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Timothy Foster, Judy Higgins, Elisabet Josefsson, Joan Geoghegan, Guy Dequesne, Andrej Tarkowski, Carlake Andersson
  • USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES
    Publication number: 20120208743
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Application
    Filed: April 25, 2012
    Publication date: August 16, 2012
    Inventors: Thomas P. STOSSEL, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski, Erlc Leuchovius
  • Methods of using gelsolin levels to characterize a subject's risk of developing rheumatoid arthritis
    Patent number: 8198094
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: June 12, 2012
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas P. Stossel, Teresia Anna Charlotta Magnuson Osborn, Andrej Tarkowski, Eric Leuchovius, legal representative
  • Use of Gelsolin to Diagnose and Treat Inflammatory Desease (Stossel)
    Publication number: 20100227807
    Abstract: The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).
    Type: Application
    Filed: March 15, 2007
    Publication date: September 9, 2010
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Tomas P. Stossel, Teresia Anna Charlotta, Andrej Tarkowski
  • Use Of Resistin Antisense Oligonucleotides And/Or Sirna Molecules In The Treatment Of Rheumatoid Arthritis
    Publication number: 20080039411
    Abstract: The present invention relates to the use of oligonucleotides antisense to part of the resistin gene and siRNA blocking the action of resistin for the treatment of Rheumatoid Arthritis. The present invention also relates to the determination of the onset of rheumatoid arthritis.
    Type: Application
    Filed: February 23, 2005
    Publication date: February 14, 2008
    Inventors: Ulf Smith, Ivan Nagaev, Maria Bokarewa, Andrej Tarkowski
  • Use of etoposide
    Publication number: 20030148963
    Abstract: The present invention relates to the use of etoposide at the manufacture of pharmaceutical compositions for the treatment of inflammations, such as arthritis in mammals, in particular humans.
    Type: Application
    Filed: November 25, 2002
    Publication date: August 7, 2003
    Inventors: Andrej Tarkowski, Margareta Verdrengh