Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

Abstract: A control device for a medical system is provided. The medical system may be a medical diagnosis and/or medical therapy system. The medical system may include a control unit operable to be used to carry out control processes that control the medical system, and a mobile handheld control unit operable to control at least one controllable element of the medical system by a user. The control device may be configured so that one or more control processes may only be carried out by the control unit when the mobile handheld control unit is located at a predefined location.

Abstract: A system for wireless transmission of signals is provided. The system includes a mobile operator unit that is operable to transmit signals; and a base unit of a safety-critical device that is operable to receive signals from the mobile operator unit. The mobile operator unit is operable to categorize the signals to be transmitted as safety-relevant control signals and non-critical communication signals. Only the safety-relevant control signals are checked for error-free transmission. The non-critical communication signals are transmitted without error safety checking.

Abstract: An apparatus is provided for determining and monitoring parameters of a radiation treatment. The apparatus produces a first image of a region of a patient body to be radiated using a medical imaging process, determines a parameter setting of a radiation system using the first image, and provides the radiation treatment to the body region to be radiated using the radiation system with the determined parameter setting. The apparatus further produces a second image of the body region radiated with the parameter setting, automatically comparing the first image and the second image, and generates a deviation signal when a difference between the first image and the second image exceeds a predetermined threshold value.

Abstract: An apparatus for supporting a patient during radiation therapy includes a treatment table that is pivotable about a horizontal axis, and a laser measurement system which is designed to indicate a non-horizontal orientation of the treatment table to be adopted during the radiation therapy.

Abstract: A particle therapy system for irradiating a volume of a patient to be irradiated with high-energy particles is provided. The system includes a radiation outlet of a radiation delivery and acceleration system from which a particle beam exits in order to interact with the patient positioned in an irradiation position; an imaging device for verifying the position of the volume to be irradiated in relation to the particle beam; and a patient-positioning device with which the patient can be brought into the irradiation position for irradiation. The imaging device checks the position of the volume to be irradiated in an imaging position of the patient that is spatially remote from the irradiation position, and the patient-positioning device automatically changes position between imaging position and irradiation position.

Abstract: A method is provided for determining and monitoring parameters of a radiation treatment. The method comprises producing a first image of a region of a patient body to be radiated using a medical imaging process, determining a parameter setting of a radiation system using the first image, and providing the radiation treatment to the body region to be radiated using the radiation system with the determined parameter setting. The method further comprises producing a second image of the body region radiated with the parameter setting, automatically comparing the first image and the second image, and generating a deviation signal when a difference between the first image and the second image exceeds a predetermined threshold value.

Abstract: A medical examination and treatment apparatus includes a robot operable to control a tool, and an internal position-determination system to measure a position of the tool by determining a setting of adjusting elements of the robot. The apparatus further includes an external position-determination system to measure the position of the tool, and a position monitoring system to compare the position of the tool determined by the internal position-determination system with the position of the tool determined by the external position-determination system. A mobility of the tool is restricted if an adjustable threshold relating to deviations between position measurements is exceeded.

Abstract: An apparatus is provided for determining and monitoring parameters of a radiation treatment. The apparatus produces a first image of a region of a patient body to be radiated using a medical imaging process, determines a parameter setting of a radiation system using the first image, and provides the radiation treatment to the body region to be radiated using the radiation system with the determined parameter setting. The apparatus further produces a second image of the body region radiated with the parameter setting, automatically comparing the first image and the second image, and generates a deviation signal when a difference between the first image and the second image exceeds a predetermined threshold value.

Abstract: The invention relates to a patient-positioning device for positioning a patient in an irradiation position in a radiation therapy arrangement, in particular in a particle radiation therapy arrangement comprising a patient supporting module, which is provided with a patient supporting device for holding the patient in a body holder where the irradiation is to be carried out, wherein, said patient supporting device is mounted on a base unit in such a way that it is rotatable about an axis by means of a bearing, said base unit is provided with a coupling element, the inventive device is also provided with a positioning arm, which comprises several joints and a coupling point for coupling the coupling element and for freely positioning the patient in any predefined irradiation position by adjusting the angle of rotation of the patient supporting module.

Abstract: An imaging device and therapy facility are provided. An imaging device includes a table that supports a patient. An image-making unit is operative to create digital picture data of a body region of the patient. The image-making unit is operative to three-dimensionally scale the coordinates of the picture data recorded with respect to a space coordinate system that is stationary with the table, with respect to a table coordinate system that is stationary with a patient support of the table, or with respect to both the space coordinate system and the table coordinate system.

Abstract: An apparatus for supporting a patient during radiation therapy includes a treatment table that is pivotable about a horizontal axis, and a laser measurement system which is designed to indicate a non-horizontal orientation of the treatment table to be adopted during the radiation therapy.

Abstract: The invention relates to a treatment room for a particle therapy system that has a treatment room isocenter, which can be set variably during treatment and forms an origin of a coordinate system, and a patient positioning apparatus for automatically positioning the patient with reference to the set treatment room isocenter.

Abstract: A control device for a medical system is provided. The medical system may be a medical diagnosis and/or medical therapy system. The medical system may include a control unit operable to be used to carry out control processes that control the medical system, and a mobile handheld control unit operable to control at least one controllable element of the medical system by a user. The control device may be configured so that one or more control processes may only be carried out by the control unit when the mobile handheld control unit is located at a predefined location.

Abstract: A system for wireless transmission of signals is provided. The system includes a mobile operator unit that is operable to transmit signals; and a base unit of a safety-critical device that is operable to receive signals from the mobile operator unit. The mobile operator unit is operable to categorize the signals to be transmitted as safety-relevant control signals and non-critical communication signals. Only the safety-relevant control signals are checked for error-free transmission. The non-critical communication signals are transmitted without error safety checking.

Abstract: An electrically conductive connection is provided. The electrically conductive connection includes a gantry, rotatable about a pivot axis, and a stand. The connection comprising a wireless electrical contact, and at least one defined rotary position of the gantry. The connection including a slipring and brush or a slipring and non-contact transmission. A radiation therapy system and method for operating a gantry of a radiation therapy system is also provided.

Abstract: The invention relates to a gantry system for a particle therapy facility, having a beam guidance gantry which has elements for beam guidance, and having a measurement gantry which has a device for beam monitoring. The measurement gantry and beam guidance gantry are thus of a mutually independent design and are, in particular, arranged in a mutually concentric manner. A gantry system of this kind is inter alia less susceptible to mechanical deviations during rotation of the beam guidance gantry.

Abstract: A particle therapy system is provided. The particle therapy system includes a rotatable gantry with a gantry wall that surrounds an interior. A small irradiation chamber, with an irradiation chamber wall, is located inside the interior. The irradiation chamber wall is spaced apart from the gantry wall, and a deflection chamber is embodied between the two walls. The irradiation chamber wall includes a plurality of wall elements, which to enlarge the irradiation chamber are adjustable in the direction of the deflection chamber, for example, when positioning a treatment table in the small irradiation chamber, such that an opening in the irradiation chamber wall is created.

Abstract: The present embodiments relate to a device for obtaining image data for planning a radiation therapy of a patient. The device includes a CT gantry and a patient positioning unit. The patient positioning unit is designed in such a way that the patient can be brought in space into any desired body position in which the radiation therapy is also carried out. The CT gantry is arranged in a freely moveable fashion in such a way that imaging for the purpose of radiation therapy planning can be carried out in this body position of the patient.