Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A strut measurement and feedback device and corresponding systems and methods for use with an external fixator are disclosed. The strut measurement and feedback device can be attached to a strut of an external fixator. The strut measurement and feedback device can confirm that the strut measurement and feedback device is attached to a proper strut to be adjusted. The strut measurement and feedback device can provide real-time feedback to an individual as the length of the strut is being adjusted to ensure the length adjustment complies with a prescription for the length of the strut. As a result, a patient can more effectively comply with the prescription as adjustments to the strut are made over time, thereby improving the likelihood of successful bone alignment.

Abstract: A dispensing system includes a container, a holder, and a signal processing module. The container includes a body configured to store a liquid and a conductive strip coupled to an outer surface of the body. The holder is configured to receive the container. The holder includes an electrical contact configured to contact the conductive strip when the container is received in the holder. The signal processing module is in electrical communication with the electrical contact. The signal processing module is configured to receive signals from the electrical contact to determine a level of liquid within the container body based on the signals when the container is received in the holder.

Abstract: There is disclosed a piezoelectric ceramic having the composition: a[PbTiO3]-b[SrTiO3]-c[BiFeO3]-d[(KxBi1-x)TiO3]; wherein 0.4<x<0.6; 0.1<a<0.4; 0.01<b?0.2; c?0.05; d?0.01; and a+b+c+d=1 optionally comprising an A- or B-site metal dopant in an amount of up to 2 at. %.

Abstract: A container for dispensing a liquid includes a body and a piercing device. The body includes an interior storage volume, an outlet through the first wall for dispensing the liquid, a first track disposed in a first side wall of the body, and a second track disposed in a second side wall of the body, the second side wall opposite the first side wall. The piercing device can be slidably coupled to the body and includes a first rail configured to slide within the first track, a second rail configured to slide within the second track, and a piercer that includes a piercing end. The piercer can slide from a first position to a second position to pierce the body and create a vent opening.

Abstract: A dispensing system including a container and a dispenser. In some embodiments, the container includes a container body, a dispensing opening, and a seal over the dispensing opening. In some embodiments, the dispenser includes a base, a drawer, a piercing tube, and a dispensing tap. In some embodiments, the base is configured to receive the container. In some embodiments, the drawer is moveable relative to the base between a first position and a second position. In some embodiments, the piercing tube is coupled to and moveable with the drawer. In some embodiments, the dispensing tap is in fluid communication with the piercing tube. In some embodiments, the piercing tube is configured to pierce the seal of container when the container is received in the base and the drawer is moved from the first position to the second position.

Abstract: A mixture for forming a wear resistant layer on a substrate comprises particles of a first wear resistant particle type, particles of a second wear resistant particle type and a wear resistant layer binder for binding the first and the second wear resistant particles in the wear resistant layer when the layer is formed. As well, wear resistant particle size distributions for the first and second wear resistant particle types have a first mode and a second mode. The first particle type is associated with the first mode and the second particle type is associated with the second mode. Moreover, a number of first wear resistant particles associated with the first mode is larger than a number of second wear resistant particles associated with the second mode. Further, the second mode is larger than the first mode.

Abstract: According to various embodiments, a processing subsystem includes: a processor mounted on a first printed circuit board that is oriented parallel to a first plane; a heat sink thermally coupled to the processor; a second printed circuit board that is communicatively coupled to the first printed circuit board and oriented parallel to a second plane, wherein the second plane is not parallel with the first plane; and at least one cooling fan that is positioned to direct a cooling fluid through the heat sink in a direction parallel to the first plane.

Abstract: A computing device comprises: a heat sink that has a plurality of cooling fins and a vapor chamber; one or more heat-generating electronic devices that are thermally coupled to the vapor chamber; and at least one cooling fan configured to direct cooling air across the plurality of cooling fins, wherein a first fin included in the plurality of cooling fins and a second fin included in the plurality of cooling fins form a first air passage that has a first air inlet opening and a first air outlet opening, and wherein the first fin is adjacent to the second fin, and a first distance between the first fin and the second fin proximate to the first air inlet opening is less than a second distance between the first fin and the second fin proximate to the first air outlet opening.

Abstract: A graphics subsystem includes a printed circuit board (PCB), a set of one or more fans, and a heat sink. A graphics processing unit (GPU) is integrated into the PCB. The PCB is shortened to occupy a portion of the width of the graphics subsystem. The heat sink is coupled to the PCB and/or GPU and configured to extend beyond an edge of the PCB, thereby occupying a larger portion of the width of the graphics subsystem compared to the PCB. A first fan is disposed partially or fully beyond the edge of the PCB and is configured to direct air through the portion of the heat sink that extends beyond the edge of the PCB, along a first airflow path, and out of the graphics subsystem. A second fan is configured to direct air through the heat sink, along a second airflow path, towards the GPU.

Abstract: A dispensing system including a container and a dispenser. In some embodiments, the container includes a container body, a dispensing opening, and a seal over the dispensing opening. In some embodiments, the dispenser includes a base, a drawer, a piercing tube, and a dispensing tap. In some embodiments, the base is configured to receive the container. In some embodiments, the drawer is moveable relative to the base between a first position and a second position. In some embodiments, the piercing tube is coupled to and moveable with the drawer. In some embodiments, the dispensing tap is in fluid communication with the piercing tube. In some embodiments, the piercing tube is configured to pierce the seal of container when the container is received in the base and the drawer is moved from the first position to the second position.

Abstract: A dispensing system including a container and a dispenser. In some embodiments, the container includes a container body, a dispensing opening, and a seal over the dispensing opening. In some embodiments, the dispenser includes a base, a drawer, a piercing tube, and a dispensing tap. In some embodiments, the base is configured to receive the container. In some embodiments, the drawer is moveable relative to the base between a first position and a second position. In some embodiments, the piercing tube is coupled to and moveable with the drawer. In some embodiments, the dispensing tap is in fluid communication with the piercing tube. In some embodiments, the piercing tube is configured to pierce the seal of container when the container is received in the base and the drawer is moved from the first position to the second position.

Abstract: Real-time evaluation and enhancement of image quality prior to capturing an image of a document on a mobile device is provided. An image capture process is initiated on a mobile device during which a user of the mobile device prepares to capture the image of the document, utilizing hardware and software on the mobile device to measure and achieve optimal parameters for image capture. Feedback may be provided to a user of the mobile device to instruct the user on how to manually optimize certain parameters relating to image quality, such as the angle, motion and distance of the mobile device from the document. When the optimal parameters for image capture of the document are achieved, at least one image of the document is automatically captured by the mobile device.

Abstract: For mechanical keyboards or other input devices with individual mechanical key buttons, and particularly for compact keyboards used for laptops and other such devices, the size of the up and down arrow keys is usually half the size of most other keys on the keyboard. For example, each letter key on a physical keyboard is typically double the size of each of the up and down arrow keys on that same keyboard. Due to the smaller physical size of the up and down arrow keys, a modified mechanical configuration is used which results in a variation in the tactile feel of the various buttons of the keyboard for a user. The present disclosure discloses a capacitive touch enabled key with a corresponding tactile button to allow the key to represent multiple different inputs while also maintaining a same tactile response as other single input keys of the input device.

Abstract: Real-time evaluation and enhancement of image quality prior to capturing an image of a document on a mobile device is provided. An image capture process is initiated on a mobile device during which a user of the mobile device prepares to capture the image of the document, utilizing hardware and software on the mobile device to measure and achieve optimal parameters for image capture. Feedback may be provided to a user of the mobile device to instruct the user on how to manually optimize certain parameters relating to image quality, such as the angle, motion and distance of the mobile device from the document. When the optimal parameters for image capture of the document are achieved, at least one image of the document is automatically captured by the mobile device.

Abstract: Crop is carried into a feed opening of a harvester by two side drapers, two rear back sheets defining an opening between inner edges, a central feed draper and a roller with end flight portions and a central finger portion located above the feed draper. In this geometry, a bottom tangent to the flight portions has a position which is at a height below the rear edge of the side drapers. The roller axis of the feed roller is behind the rear edge of the side drapers and behind a common plane containing the back sheets. The inner guide roller of each of the first and second side drapers is located inwardly of the inner edge of the first back sheet and inwardly of an outer end of the end flight portion. A forward most tangent to the flight portions projects forward of or proud of the common back sheet plane.

Abstract: A power adapter has a solenoid actuated retaining latch controlled by an electronic circuit that detects the presence or absence of AC mains voltage. When the assembled AC-DC adapter and plug assembly are removed from the wall, the latch detects removal and unlocks the plug assembly for easy removal without undue force required by the user. The circuit is designed for minimal power consumption, and the solenoid only consumes power when it is engaging or disengaging the latch.

Abstract: A computing device comprises: a base portion; a display portion that is movably coupled to the base portion and includes a housing having a movable panel and one or more fixed panels; and a mechanical assembly that positions the movable panel away from the one or more fixed panels as the display portion opens away from the base portion.

Abstract: A container for dispensing a liquid includes a body and a piercing device. The body includes an interior storage volume, an outlet through the first wall for dispensing the liquid, a first track disposed in a first side wall of the body, and a second track disposed in a second side wall of the body, the second side wall opposite the first side wall. The piercing device can be slidably coupled to the body and includes a first rail configured to slide within the first track, a second rail configured to slide within the second track, and a piercer that includes a piercing end. The piercer can slide from a first position to a second position to pierce the body and create a vent opening.