Abstract: A first aspect of the invention provides a method of fault monitoring in a utility supply network, the method comprising: receiving user queries, each user query about a performance of the network at a respective location; defining a region based on the locations specified in the received user queries; determining an estimate of a user population in the region; and according the region, based on the estimate, a priority for one or more of fault investigation and remediation.

Abstract: A method of diagnosing faults in a utility supply network involves receiving performance data indicative of performance of the utility supply network, and receiving historical performance data indicative of a historical performance of the utility supply network and a fault associated with the historical performance data. A fault in the utility supply network is determined based on a comparison of the performance data with the historical performance data.

Abstract: A method of treating a cancer in a mammalian subject afflicted with the cancer, consisting essentially of administering to the subject a therapeutically effective amount of a platinum-based anticancer agent, and administering to the subject a therapeutically effective amount of a pentaaza macrocyclic ring complex corresponding to the Formula (I) below, prior to, concomitantly with, or after administration of the platinum-based anticancer agent, whereby response of the cancer to the platinum-based anticancer agent is increased.

Abstract: Methods, systems and computer program products for evacuating memory from a drawer in a live multi-node system are provided. Aspects include placing a first drawer into an evacuation mode. The evacuation mode includes a cessation of non-evacuation operations and provides for a transfer of data stored by memory of the first drawer to a destination drawer using dynamic memory reallocation (DMR). Aspects also include transmitting a store request by the first drawer to the destination drawer. The store request represents a request to transfer the data stored by the memory of the first drawer to the destination drawer for storage by the destination drawer. Aspects also include transmitting the data stored by the memory of the first drawer to the destination drawer. The data is transmitted by the first drawer using a local pool of fetch/store controllers.

Abstract: The invention provides a computer-implemented method of planning a path for a mobile robot such as an autonomous vehicle in the presence of K obstacles. The method uses, for each of the K obstacles, a shape Bk and a density function pk(x) representing the probabilistic position of the obstacle. The method repeats the following steps for at least two different paths A:—choosing a path A, where A is the swept area of the robot within a given time interval; and—calculating based on the density function of each obstacle and the swept path an upper bound on the total probability of at least one collision FD between the robot and the K obstacles. This allows a number of candidate paths to be ranked for safety. By precomputing factors of the computational steps over K obstacles, the computation per path is O(N), and not O(NK). A safety threshold can be used to filter out paths below that threshold.

Abstract: Disclosed are analogues of hinokitiol, methods for preparing them, and pharmaceutical compositions thereof. Also disclosed are methods for their use in treating iron-related diseases.

Abstract: Where elements in a utility supply network are dependent upon another element for their proper operation, determining, by reference to user queries about network performance, whether there are faults in the dependent elements or a fault in the element upon which the dependent elements rely.

Abstract: A port configuration replication system includes a first networking device including a first port, and a second networking device including a second port. A management device communicates with the first networking device to provide a first networking device Graphical User Interface (GUI) that displays port configuration details for the first port. The management device then copies the port configuration details, and analyzes the port configuration details to identify port configuration replication information. The management device then communicates with the second networking device to display a second networking device GUI that provides for the configuration of the second port, and provides the port configuration replication information in the second networking device GUI in order to provide for the configuration of the second port.

Abstract: Provided are systems, methods, and media for simultaneous, non-atomic request processing of snooped operations of a broadcast scope within a SMP system. An example method includes detecting, by a first controller, based on a set of coherency resolution conditions, whether there are coherency resolution problems between two snooped operations. The method includes in response to detecting, by the first controller, that coherency resolution problems will not result, transmitting, from the first controller to a second controller, an indication signal indicating that coherency resolution problems will not result from the operation. The set of coherency resolution conditions includes: (a) detecting that a second operation of the two snooped operations operation is of a predetermined type, (b) detecting at time of snooping of the second operation that a directory state does not allow for exclusive data, and (c) detecting that the first controller has started committing to an update.

Abstract: Methods, systems and computer program products for evacuating memory from a drawer in a live multi-node system are provided. Aspects include placing a first drawer into an evacuation mode. The evacuation mode includes a cessation of non-evacuation operations and provides for a transfer of data stored by memory of the first drawer to a destination drawer using dynamic memory reallocation (DMR). Aspects also include transmitting a store request by the first drawer to the destination drawer. The store request represents a request to transfer the data stored by the memory of the first drawer to the destination drawer for storage by the destination drawer. Aspects also include transmitting the data stored by the memory of the first drawer to the destination drawer. The data is transmitted by the first drawer using a local pool of fetch/store controllers.

Abstract: Provided are systems, methods, and media for simultaneous, non-atomic request processing of snooped operations of a broadcast scope within a SMP system. An example method includes detecting, by a first controller, based on a set of coherency resolution conditions, whether there are coherency resolution problems between two snooped operations. The method includes in response to detecting, by the first controller, that coherency resolution problems will not result, transmitting, from the first controller to a second controller, an indication signal indicating that coherency resolution problems will not result from the operation. The set of coherency resolution conditions includes: (a) detecting that a second operation of the two snooped operations operation is of a predetermined type, (b) detecting at time of snooping of the second operation that a directory state does not allow for exclusive data, and (c) detecting that the first controller has started committing to an update.

Abstract: This invention relates to a method of treating cancer by administering a PARP inhibitor in combination with a PD-1 axis binding antagonist to a patient in need thereof.

Abstract: A patient interface face contact element comprises a surface for contacting the face of a patient, and a connection face for coupling the patient interface face contact element to a support using a magnetic coupling. The support is also provided as well as the complete patient interface. Headgear strap clips can also be retained magnetically.

Abstract: A Wireless Wide Area Network (WWAN)-enabled remote switch management system includes a management device having a management device WWAN communication subsystem that is configured to transmit management commands from the management device through a WWAN. The WWAN-enabled remote switch management system also includes a switch device having a chassis. A switch device wired communication subsystem is located in the chassis, coupled to a Local Area Network (LAN), and is not coupled to the Internet. A switch device WWAN communication subsystem is located in the chassis and is configured to receive management commands from the management device through the WWAN. A switch management engine is located in the chassis, coupled to the switch device WWAN communication subsystem, and is configured to receive the management commands from the switch device WWAN communication subsystem, and execute the management commands to perform a management action on the switch device.

Abstract: Where elements in a utility supply network are dependent upon another element for their proper operation, determining, by reference to user queries about network performance, whether there are faults in the dependent elements or a fault in the element upon which the dependent elements rely.

Abstract: A patient interface face contact (14) element comprises a surface for contacting the face of a patient, and a connection face for coupling the patient interface face contact element to a support (15) using a magnetic coupling (30). The support is also provided as well as the complete patient interface. Headgear strap clips can also be retained magnetically.

Abstract: Provided are methods of treating bladder cancer (e.g., urothelial carcinoma, UC) in a subject having bladder cancer, e.g., UC, with an effective dose regimen of an anti-PD-L1 antibody, e.g., durvalumab, or an antigen binding fragment thereof. Also provided are methods in which an anti-PD-L1 antibody is used in combination with another immunotherapeutic agent, e.g., tremelimumab to treat a bladder cancer, e.g., UC, in a subject having bladder cancer. In some cases, the subject undergoing treatment is identified as having a bladder cancer or tumor that is PD-L1-low/neg, or PD-L1-high. Methods are also provided in which anti-PD-L1 antibody treatment of bladder cancer is used following a standard of care or first-line therapy in subjects who have progressed following such therapies or who have relapsed after a prior treatment regimen.

Abstract: A networking device includes a chassis, a port located on the chassis, a port configuration display located on the chassis, and a plurality of port configuration buttons located on the chassis. A port configuration engine is included in the chassis and is coupled to each of the port, the port configuration display, and the plurality of port configuration buttons. The port configuration engine is configured to provide a current Virtual Local Area Network (VLAN) assignment for the port for display on the port configuration display. When the port configuration engine determines that a first port configuration button of the plurality of port configuration buttons has been actuated at least once, the port configuration engine modifies the current VLAN assignment for the port to provide a modified VLAN assignment for the port, and provides the modified VLAN assignment for the port for display on the port configuration display.

Abstract: A disposable staining system is provided including an insertable module configured to receive a biological sample therein, the insertable module including a well in which the biological sample is positioned; and a staining cartridge configured to receive the insertable module including the biological sample therein, the insertable module being positioned in the staining cartridge. The insertable module has first and second inclined planes on opposing sides of an upper surface of the insertable module. A sled configured to receive the insertable module has corresponding first and second inclined planes on a bottom surface thereof. The first and second inclined planes of the insertable module and the first and second inclined planes of the sled are configured to transform horizontal movement of the insertable module into the staining cartridge into a vertical movement of the sled such that the sled is pushed upward.

Abstract: A Wireless Wide Area Network (WWAN)-enabled remote switch management system includes a management device having a management device WWAN communication subsystem that is configured to transmit management commands from the management device through a WWAN. The WWAN-enabled remote switch management system also includes a switch device having a chassis. A switch device wired communication subsystem is located in the chassis, coupled to a Local Area Network (LAN), and is not coupled to the Internet. A switch device WWAN communication subsystem is located in the chassis and is configured to receive management commands from the management device through the WWAN. A switch management engine is located in the chassis, coupled to the switch device WWAN communication subsystem, and is configured to receive the management commands from the switch device WWAN communication subsystem, and execute the management commands to perform a management action on the switch device.