Abstract: Provided herein are devices, systems, and methods for detection of sensors, such as light-detectable sensors. The devices or systems as described herein may comprise an illumination assembly configured to direct a light to at least a well of a plurality of wells in the array of wells and a detection assembly configured to detect a signal from the well.

Abstract: Provided herein are devices, systems, and methods for detection of sensors, such as light-detectable sensors. The devices or systems as described herein may comprise an illumination assembly configured to direct a light to at least a well of a plurality of wells in the array of wells and a detection assembly configured to detect a signal from the well.

Abstract: Provided herein are devices, systems, and methods for detection of sensors, such as light-detectable sensors. The devices or systems as described herein may comprise an illumination assembly configured to direct a light to at least a well of a plurality of wells in the array of wells and a detection assembly configured to detect a signal from the well.

Abstract: Provided herein are devices, systems, and methods for detection of sensors, such as light-detectable sensors. The devices or systems as described herein may comprise an illumination assembly configured to direct a light to at least a well of a plurality of wells in the array of wells and a detection assembly configured to detect a signal from the well.

Abstract: Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic device. The apparatus provided includes a microfluidic device coupled to a multi-well structure and an interface for controlling the flow of media within the microchannel device.

Abstract: The present invention provides a system for assaying ion-channels. In some embodiments, the ion-channel assay provides a reversible change to the membrane potential of a target, e.g., a cell, upon exposure to light. In some embodiments, the membrane potential readout is fed back through a control circuit to regulate the excitation intensity of the illumination sources that induce, respectively, hyperpolarizing and depolarizing currents, thereby effecting closed-loop control of the membrane potential.

Abstract: Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic device. The apparatus provided includes a microfluidic device coupled to a multi-well structure and an interface for controlling the flow of media within the microchannel device.

Abstract: A device and a method are provided for holding a stereotactic probe in position after the probe has been precisely positioned by stereotactic procedures, such as brain surgery. The device, a stereotactic probe holder, is adjustable, as it is capable of being positioned to contact and grip a probe at a position between a stereotactic frame and a patient's head, and is suitable for holding the probe in a desired location. Methods of using the stereotactic probe holder are also provided. The invention is useful in maintaining the proper positioning of probes, such as deep brain stimulators, electrodes, cryoprobes, cannulae, and the like, after the initial placement of the probes during stereotactic surgery.