Patents by Inventor Andrew C. Hiatt
Andrew C. Hiatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8106169Abstract: This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e.g., leaves, seeds, tubers, etc.); transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.Type: GrantFiled: November 28, 2003Date of Patent: January 31, 2012Assignee: Phyton Holdings, LLCInventors: Kristen Briggs, Todd Glancy, Mich B. Hein, Andrew C. Hiatt, Anton S. Karnoup, W. H. Kerr Anderson, Dayakar Pareddy, Joseph Petolino, Beth Rubin-Wilson, Doug Taylor, Jean L. Roberts
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Publication number: 20080115244Abstract: The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.Type: ApplicationFiled: November 28, 2006Publication date: May 15, 2008Applicant: The Regents of University of CaliforniaInventors: Andrew C. Hiatt, Julian K.-C. Ma, Thomas Lehner
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Patent number: 7311912Abstract: Targeting molecules for use in delivering biological agents to epithelial tissue are disclosed. Upon delivery, the biological agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molecules may be used, for example, for the delivery of therapeutic agents.Type: GrantFiled: January 9, 1998Date of Patent: December 25, 2007Assignee: Plantbodies CorporationInventors: Mich B. Hein, Andrew C. Hiatt, John H. Fitchen
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Patent number: 7282625Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: GrantFiled: February 27, 2003Date of Patent: October 16, 2007Assignee: The Scripps Research InstituteInventors: Mich B. Hein, Andrew C. Hiatt
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Patent number: 7211389Abstract: The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.Type: GrantFiled: February 18, 2004Date of Patent: May 1, 2007Assignee: The Regents of the University of CaliforniaInventors: Andrew C. Hiatt, Julian K.-C. Ma, Thomas Lehner, Keith E. Mostov
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Patent number: 7101688Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: GrantFiled: February 25, 2003Date of Patent: September 5, 2006Assignee: The Scripps Research InstituteInventors: Mich B. Hein, Andrew C. Hiatt
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Patent number: 7022309Abstract: Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having ?-sheet character, each of the domains being separated by domains lacking ?-sheet character. The targeting molecule specifically binds to a basolateral factor attached to a basolateral domain of an epithelial cell surface causing internalization of a linked imaging agent into the cells. The polypeptide or imaging agent may be linked to a peptide amino acid sequence that directs delivery of the imaging agent to a carcinoma cell, a nucleus, or an endoplasmic reticulum.Type: GrantFiled: February 5, 2002Date of Patent: April 4, 2006Assignee: Biolex Newco I, Inc.Inventors: Andrew C. Hiatt, Mich B. Hein, John H. Fitchen
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Patent number: 6808709Abstract: The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates he production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins a therapeutic antibodies against mucosal and other pathogens is also contemplated.Type: GrantFiled: November 20, 2000Date of Patent: October 26, 2004Assignee: The Regents of the University of CaliforniaInventors: Andrew C. Hiatt, Julian K.-C. Ma, Thomas Lehner, Keith E. Mostov
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Publication number: 20040199945Abstract: Arrays of immunoglobulin binding proteins in plants or plant cells are provided. Such arrays comprise plants or plant cells transformed with polynucleotides encoding multiple different immunoglobulin binding proteins, or polypeptide components thereof. Methods are further provided for genetic segregation of the transformation events such that each transformant in an array is capable of producing progeny capable of expressing one or more immunoglobulin binding proteins, including multi-subunit proteins.Type: ApplicationFiled: February 19, 2004Publication date: October 7, 2004Applicant: Epicyte Pharmaceutical, Inc.Inventors: Andrew C. Hiatt, Mitch B. Hein
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Patent number: 6696620Abstract: Arrays of immunoglobulin binding proteins in plants or plant cells are provided. Such arrays comprise plants or plant cells transformed with polynucleotides encoding multiple different immunoglobulin binding proteins, or polypeptide components thereof. Methods are further provided for genetic segregation of the transformation events such that each transformant in an array is capable of producing progeny capable of expressing one or more immunoglobulin binding proteins, including multi-subunit proteins.Type: GrantFiled: May 2, 2000Date of Patent: February 24, 2004Assignee: Epicyte Pharmaceutical, Inc.Inventors: Andrew C. Hiatt, Mich B. Hein
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Publication number: 20030224443Abstract: Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having &bgr;-sheet character, each of the domains being separated by domains lacking &bgr;-sheet character. The targeting molecule specifically binds to a basolateral factor attached to a basolateral domain of an epithelial cell surface causing internalization of a linked imaging agent into the cells. The polypeptide or imaging agent may be linked to a peptide amino acid sequence that directs delivery of the imaging agent to a carcinoma cell, a nucleus, or an endoplasmic reticulum.Type: ApplicationFiled: February 5, 2002Publication date: December 4, 2003Applicant: Epicyte Pharmaceutical, Inc.Inventors: Andrew C. Hiatt, Mich B. Hein, John H. Fitchen
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Publication number: 20030079253Abstract: Arrays of immunoglobulin binding proteins in plants or plant cells are provided. Such arrays comprise plants or plant cells transformed with polynucleotides encoding multiple different immunoglobulin binding proteins, or polypeptide components thereof. Methods are further provided for genetic segregation of the transformation events such that each transformant in an array is capable of producing progeny capable of expressing one or more immunoglobulin binding proteins, including multi-subunit proteins.Type: ApplicationFiled: May 2, 2000Publication date: April 24, 2003Inventors: Andrew C. Hiatt, Mich B. Hein
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Publication number: 20020159958Abstract: The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.Type: ApplicationFiled: October 16, 2001Publication date: October 31, 2002Applicant: The Scripps Research InstituteInventors: Andrew C. Hiatt, Mich B. Hein
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Patent number: 6440419Abstract: Targeting molecules for use in delivering biological agents to non-polarized epithelial cells are disclosed. Upon delivery, the biological agent(s) are lethal to the epithelial cell. The targeting molecules may be used, for example, for the eradication of metastatic epithelial cells.Type: GrantFiled: October 20, 1998Date of Patent: August 27, 2002Assignee: Epicyte Pharmaceutical, Inc.Inventors: Mich B. Hein, Andrew C. Hiatt, John H. Fitchen
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Patent number: 6391280Abstract: Polypeptide targeting molecules are provided for use in delivering imaging agents to epithelial tissue. Upon delivery, the imaging agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molecules may be used, for example, for diagnostic techniques. The polypeptide may be produced by recombinant methods, and forms a closed covalent loop, contains at least three peptide domains having &bgr;-sheet character which are separated by domains lacking &bgr;-sheet character, specifically binds to a basolateral factor attached to a basolateral domain of an epithelial surface causing uptake of a linked imaging agent into cells of the epithelial surface, and is not a full length dimeric Iga. Preferably, the polypeptide is a J chain polypeptide, or a J chain polypeptide linked to an immunoglobulin heavy chain without an immunoglobulin light chain.Type: GrantFiled: January 9, 1998Date of Patent: May 21, 2002Assignee: Epicyte Pharmaceutical, Inc.Inventors: Andrew C. Hiatt, Mich B. Hein, John H. Fitchen
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Patent number: 6303341Abstract: The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.Type: GrantFiled: May 14, 1999Date of Patent: October 16, 2001Assignee: Planet Biotechnology, Inc.Inventors: Andrew C. Hiatt, Julian K.-C. Ma, Thomas Lehner, Keith E. Mostov
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Patent number: 6251392Abstract: Targeting molecules for use in delivering biological agents to non-polarized epithelial cells are disclosed. Upon delivery, the biological agent(s) are lethal to the epithelial cell. The targeting molecules may be used, for example, for the eradication of metastatic epithelial cells.Type: GrantFiled: October 20, 1997Date of Patent: June 26, 2001Assignee: Epicyte Pharmaceuticals, Inc.Inventors: Mich B. Hein, Andrew C. Hiatt, John H. Fitchen
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Patent number: 6232465Abstract: A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3′-hydroxyl group; attaching a mononucleotide selected according to the order of the predetermined nucleotide sequence to the 3′-hydroxyl of the initiating substrate in a solution containing a catalytic amount of an enzyme capable of catalyzing the 5′ to 3′ phosphodiester linkage of the 5′-phosphate of the mononucleotide to the 3′-hydroxyl of the initiating substrate, wherein the mononucleotide contains a protected 3′-hydroxyl group, whereby the protected mononucleotide is covalently linked to the initiating substrate and further additions are hindered by the 3′-hydroxyl protecting group. Methods in which a mononucleotide immobilized on a solid support is added to a free polynucleotide chain are also disclosed.Type: GrantFiled: June 7, 1995Date of Patent: May 15, 2001Inventors: Andrew C. Hiatt, Floyd Rose
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Patent number: 6214987Abstract: A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3′-hydroxyl group; attaching a mononucleotide selected according to the order of the predetermined nucleotide sequence to the 3′-hydroxyl of the initiating substrate in a solution containing a catalytic amount of an enzyme capable of catalyzing the 5′ to 3′ phosphodiester linkage of the 5′-phosphate of the mononucleotide to the 3′-hydroxyl of the initiating substrate, wherein the mononucleotide contains a protected 3′-hydroxyl group, whereby the protected mononucleotide is covalently linked to the initiating substrate and further additions are hindered by the 3′-hydroxyl protecting group. Methods in which a mononucleotide immobilized on a solid support is added to a free polynucleotide chain are also disclosed.Type: GrantFiled: June 7, 1995Date of Patent: April 10, 2001Inventors: Andrew C. Hiatt, Floyd Rose
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Patent number: 6136568Abstract: Disclosed is a method for synthesizing polynucleotide molecules such as genes or gene segments. A primer having 5' and 3' ends is incubated with a relatively shorter template having a 5' region non-complementary to the primer, a 3' region complementary to the 3' end of the primer, and a non-reactive 3' terminus to allow the 3' region of the template to anneal to the primer. The annealed product is reacted with at least one nucleotide in the presence of a template-dependent polynucleotide polymerase to produce a primer extended at its 3' end by at least one nucleotide complementary to the 5' region of the template. The extended primer is then dissociated from the template. The extended primer is further extended by repeating this cycle for sufficient cycles, wherein the templates and enzymes may differ from cycle to cycle, to obtain the object polynucleotide. Also disclosed are template libraries and kits containing said libraries for use in conjunction with the polynucleotide synthesis method.Type: GrantFiled: September 15, 1997Date of Patent: October 24, 2000Inventors: Andrew C. Hiatt, Floyd D. Rose