Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Abstract: The invention relates to cheese and cheese-like products comprising about 0.2 to about 6% by weight ?s-casein, ?-casein, or a combination thereof, at least about 5% by weight of one or more hydrocolloids comprising one or more starches, and wherein the cheese or cheese-like product has one or more characteristics of a dairy product, such as flavour, taste, aroma, body, appearance, texture, firmness, handling, density, structure, coagulation, binding, leavening, aeration, foaming, emulsification, elasticity, viscoelasticity, melt, creaminess and mouthfeel.

Abstract: Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.

Abstract: A processing system may apply a community detection process to a feature graph database to identify a plurality of communities of features, the feature graph database comprising: a plurality of objects, each associated with one of a feature or a concept, and a plurality of relationships between the plurality of objects. Next, the processing system may label a first plurality of features of the feature graph database with at least a first community label, where the first plurality of features comprises features of at least a first community of the plurality of communities. The processing system may then obtain a search associated with at least one feature of the feature graph database, where the at least one feature is a part of the at least the first plurality of features of the at least the first community, and provide the first plurality of features in response to the search.

Abstract: A processing system may obtain a request to add at least a first feature to a feature graph database, where the request comprises a first feature ontology of the first feature, and where the first feature ontology comprises: a label of the first feature and a relationship of the first feature to a concept or to another feature. The processing system may then identify whether the first feature is a duplicate of a second feature in the feature graph database based at least upon the first feature ontology and a second feature ontology of the second feature and generate an indication of whether the first feature is a duplicate in response to the identifying.

Abstract: Provided herein are materials and methods for detecting colorectal neoplasms and colon cancer based on the expression levels of stool-derived eukaryotic RNA biomarkers in eukaryotic nucleic acid present in a stool sample from a subject, for example, a patient. The methods can be used for the detection of high-risk adenomas and colorectal neoplasm molecular subtypes.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: A modular enclosure system and method for repair of one or more leaks in a pipe. The modular enclosure system including a first enclosure portion configured to be disposed in a mated configuration to create a first enclosure around the pipe. Each enclosure includes a first void section configured to enclose a pipe section of the pipe. Sealant grooves extend along enclosure faces of each enclosure to seal the modular enclosure system. Each enclosure includes a sealant control system having a plurality of blocking members and configured to selectively block sealant injected in the sealant grooves. Each of the blocking members are positionable between a blocking position configured to block sealant flow in at least one of the sealant grooves and a non-blocking position.

Abstract: A non-combustible aerosol provision device for generating an aerosol from an aerosol-generating material is provided. The device includes a chamber for receiving a consumable including aerosol-generating material to enable the non-combustible aerosol provision device to generate an aerosol from the aerosol-generating material. The device further includes an adjustment mechanism to allow a user to adjust a dimension of the chamber to allow the chamber to accommodate, one at a time, each of a plurality of consumables having different sizes.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material included in a consumable, the non-combustible aerosol provision device having: a receptacle for receiving the consumable; and an adaptor configured to adapt the non-combustible aerosol provision device by varying an effective length of the receptacle such that each of a plurality consumables of different lengths, which are individually receivable in the receptacle, when received in the receptacle for use, protrude from the non-combustible aerosol provision device by substantially equal amounts.

Abstract: Bioplastic compositions and methods of making are described herein. The various mechanical and physical properties of the bioplastic may be varied by altering the thermoforming or incorporating an additive depending on the desired mechanical and physical properties of the end product. The bioplastic may be made entirely of biomatter and be backyard compostable.

Abstract: An assembly for retaining a pressure jacket (134) and a syringe (132) on a fluid injector, the assembly including a base plate (1902) comprising a body (1904); at least a first retaining arm (1910a) and a second retaining arm (1910b) operatively mounted on the body of the base plate, the first retaining arm having a first retaining surface at a distal end thereof and the second retaining arm having a second retaining surface at a distal end thereof, wherein the first retaining surface and the second retaining surface are configured for abutting a distal surface of at least one of the pressure jacket and the syringe; a linkage assembly operatively connected to at least one of the first retaining arm and the second retaining arm, wherein the linkage assembly is configured to move at least one of the first retaining arm and the second retaining arm between at least a first open position and a closed position.

Abstract: A processing system including at least one processor may obtain a personal identifier comprising a plurality of characters and generate a first embedding of the personal identifier in accordance with an embedding model. The processing system may then identify one or more embeddings of other personal identifiers that are within a threshold distance of the first embedding and generate an alert in response to the identifying of the one or more embeddings of the other personal identifiers that are within the threshold distance.

Abstract: A method for detecting threat pathways using sequence graphs includes constructing a sequence graph from a set of data containing information about activities in a telecommunications service provider network, where the sequence graph represents a subset of the activities that occurs as a sequence, providing an embedding of the sequence graph as input to a machine learning model, wherein the machine learning model has been trained to detect when an input embedding of a sequence graph is likely to indicate a threat activity, determining, based on an output of the machine learning model, whether the subset of the activities is indicative of the threat activity, and initiating a remedial action to mitigate the threat activity.

Abstract: Disclosed herein is a method and apparatus for automatic extrudate loading and alignment. An extrudate handling system includes a head end assembly and an imaging device (which may be part of the head end assembly). The imaging device is configured to image an end face of an extrudate, and generate, during translation of the extrudate, an imaging output signal indicative of a rotational position of the end face of the extrudate. The head end assembly includes a rotational effector to rotate the extrudate during translation thereof and a fixed effector rotationally fixed relative to a track. The extrudate handling system is able to determine the rotational position of the web angle of the extrudate and precisely adjust the rotational position while linearly translating the extrudate along the track. The extrudate handling system provides greater accuracy, reduced costs, and improved results.

Abstract: Mitigation of temporal generalization losses a target machine learning model is disclosed. Mitigation can be based on identifying, removing, modifying, transforming, etc., features, explanatory variables, models, etc., that can have an unstable relationship with a target outcome over time. Implementation of a more stable representation can be initiated. Temporal stability measures (TSMs) for one or more model feature(s) can be determined based on one or more variable performance metrics (VPMs). A group of one or more VPMs can be selected based on features of a model in either a development or production environment. Model feature modification can be recommended based on a TSM, which can prune a feature, transform a feature, add a feature, etc. Temporal stability information can be presented, e.g., via a dashboard-type user interface. Models can be updated based on mutations of a model comprising a feature modification(s), including competitive champion/challenger model updating.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: The present technique provides an apparatus and method for caching data. The apparatus has a cache storage to cache data associated with memory addresses, a first interface to receive access requests, where each access request is a request to access data at a memory address indicated by that access request, and a second interface to couple to a memory controller used to control access to memory. Further, cache control circuitry is used to control allocation of data into the cache storage in accordance with a power consumption based allocation policy that seeks to select which data is cached in the cache storage with the aim of conserving power associated with accesses to the memory via the second interface.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.