Patents by Inventor Andrew Crofton

Andrew Crofton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9746458
    Abstract: Methods and kits for identifying neurological conditions in a patient by determining a level of expression of dynactin subunit p62 are disclosed. The neurological conditions may include, for example, Alzheimer's Disease (AD) without cerebral amyloid angiopathy (CAA).
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: August 29, 2017
    Assignee: Loma Linda University Medical Center
    Inventors: Wolff M. Kirsch, Matthew Schrag, Andrew Crofton, Matthew Zabel, Claudius Mueller
  • Patent number: 9414967
    Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using ?-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using ?-irradiation, treating under a nitrogen plasma, or both.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: August 16, 2016
    Assignees: Loma Linda University, Loma Linda University Medical Center, North Carolina State University
    Inventors: Wolff M. Kirsch, Samuel M. Hudson, Andrew Crofton
  • Publication number: 20160184429
    Abstract: A chitosan material is treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan, and the chitosan material is formulated into a hydrogel which can be utilized as a drug delivery vehicle for medicaments or therapeutic agents to treat certain conditions, such as cancers.
    Type: Application
    Filed: August 7, 2014
    Publication date: June 30, 2016
    Inventors: Wolff M. Kirsch, Samuel M. Hudson, Andrew Crofton
  • Publication number: 20160121021
    Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using ?-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using ?-irradiation, treating under a nitrogen plasma, or both.
    Type: Application
    Filed: January 8, 2016
    Publication date: May 5, 2016
    Inventors: Wolff M. Kirsch, Samuel M. Hudson, Andrew Crofton
  • Publication number: 20160082037
    Abstract: A powder chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using ?-irradiation, treated under a nitrogen plasma, or both. A powder chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using ?-irradiation, treating under a nitrogen plasma, or both.
    Type: Application
    Filed: September 23, 2015
    Publication date: March 24, 2016
    Inventors: Wolff M. Kirsch, Samuel M. Hudson, Andrew Crofton
  • Patent number: 9259357
    Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using ?-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using ?-irradiation, treating under a nitrogen plasma, or both.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: February 16, 2016
    Assignees: Loma Linda University, Loma Linda University Medical Center, North Carolina State University
    Inventors: Wolff M. Kirsch, Samuel M. Hudson, Andrew Crofton
  • Publication number: 20150353623
    Abstract: A substance for treating a cerebral amyloid angiopathy related condition or disease affecting cerebrovasculature in a patient, comprising an inhibitor that causes inhibition of the formation of membrane attack complex of the complement system; and a vehicle for transporting the inhibitor into the cerebrovasculature; where the inhibition by the inhibitor is sufficient to decrease the incidence of or to prevent the incidence of cytolysis of the smooth muscle cells. A method for treating a cerebral amyloid angiopathy related condition or disease affecting cerebrovasculature in a patient, comprising: a) identifying a patient with a cerebral amyloid angiopathy related condition or disease; b) providing one or more than one substance that comprises an inhibitor that causes inhibition of the formation of membrane attack complex of the complement system, c) administering one or more than one dose of the one or more than one substance to the patient.
    Type: Application
    Filed: April 2, 2015
    Publication date: December 10, 2015
    Inventors: Wolff M. Kirsch, Andrew Crofton, Tanya Cupino, Charles Glabe, Samuel M. Hudson, Matthew Schrag, Harry V. Vinters, Matthew Zabel
  • Publication number: 20150297783
    Abstract: A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using ?-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using ?-irradiation, treating under a nitrogen plasma, or both.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 22, 2015
    Inventors: Wolff M. Kirsch, Samuel M. Hudson, Andrew Crofton
  • Publication number: 20150297674
    Abstract: A substance for treating a cerebral amyloid angiopathy related condition or disease affecting cerebrovasculature in a patient, comprising an inhibitor that causes inhibition of the formation of membrane attack complex of the complement system; and a vehicle for transporting the inhibitor into the cerebrovasculature; where the inhibition by the inhibitor is sufficient to decrease the incidence of or to prevent the incidence of cytolysis of the smooth muscle cells. A method for treating a cerebral amyloid angiopathy related condition or disease affecting cerebrovasculature in a patient, comprising: a) identifying a patient with a cerebral amyloid angiopathy related condition or disease; b) providing one or more than one substance that comprises an inhibitor that causes inhibition of the formation of membrane attack complex of the complement system, c) administering one or more than one dose of the one or more than one substance to the patient.
    Type: Application
    Filed: March 12, 2013
    Publication date: October 22, 2015
    Inventors: Wolff M. Kirsch, Andrew Crofton, Tanya Freeman, Charles Glabe, SAmuel M. Hudson, Matthew Schrag, Harry Vinters, Matthew Zabel
  • Publication number: 20120331573
    Abstract: Methods and kits for identifying neurological conditions in a patient by determining a level of expression of dynactin subunit p62 are disclosed. The neurological conditions may include, for example, Alzheimer's Disease (AD) without cerebral amyloid angiopathy (CAA).
    Type: Application
    Filed: April 26, 2012
    Publication date: December 27, 2012
    Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER
    Inventors: Wolff M. Kirsch, Matthew Schrag, Andrew Crofton, Matthew Zabel