Patents by Inventor Andrew Cubitt

Andrew Cubitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining the presence of an enzyme in a sample
    Patent number: 8679742
    Abstract: This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: March 25, 2014
    Assignees: The Regents of the University of California, Life Technologies Corporation
    Inventors: Roger Y. Tsien, Roger Heim, Andrew Cubitt
  • METHOD OF PRODUCING TRANSCRIPTS USING CRYPTIC SPLICE SITES
    Publication number: 20130035472
    Abstract: The invention is directed to a method of preparing a nucleic acid sequence with a modified splice site usage profile, which employs the use of a nucleic acid sequence comprising a cryptic splice donor site. The invention also provides a method of producing an alternate form of an RNA molecule encoded by a nucleic acid sequence, which nucleic acid sequence comprises a cryptic splice donor site, a heterologous nucleic acid sequence, and a splice acceptor site.
    Type: Application
    Filed: March 15, 2011
    Publication date: February 7, 2013
    Applicant: ANAPTYSBIO, INC.
    Inventors: Robert Horlick, John Macomber, Andrew Cubitt, David King
  • TANDEM FLUORESCENT PROTEIN CONSTRUCTS
    Publication number: 20100233726
    Abstract: This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.
    Type: Application
    Filed: November 4, 2009
    Publication date: September 16, 2010
    Applicants: The Regents of the University of California, Invitrogen Corporation
    Inventors: Roger Y. Tsien, Roger Heim, Andrew Cubitt
  • Fluorescent Protein Sensors of Post-Translational Modifications
    Publication number: 20080166749
    Abstract: The present invention includes a fluorescent compound that can detect an activity, such as an enzymatic activity, and exhibits quenching. The fluorescent compound can include a fluorescent protein, such as an Aequorea-related green fluorescent protein. The fluorescent compound can include a substrate site for an enzymatic activity such as a kinase activity, a phosphatase activity, a protease activity, and a glycosylase activity. The fluorescent compound of the present invention can be used to detect such enzymatic activities in samples, such as biological samples, including cells. The present invention also includes nucleic acids that encode the fluorescent compounds of the present inventions, and cells that include such nucleic acids or fluorescent compounds.
    Type: Application
    Filed: July 9, 2007
    Publication date: July 10, 2008
    Applicant: INVITROGEN CORPORATION
    Inventor: Andrew Cubitt
  • Long wavelength engineered fluorescent proteins
    Publication number: 20050079525
    Abstract: Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.
    Type: Application
    Filed: August 23, 2004
    Publication date: April 14, 2005
    Inventors: Roger Tsien, S. Remington, Andrew Cubitt, Roger Heim, Mats Ormo
  • Tandem fluorescent protein constructs
    Publication number: 20020164674
    Abstract: This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.
    Type: Application
    Filed: January 25, 2002
    Publication date: November 7, 2002
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Roger Y. Tsien, Roger Heim, Andrew Cubitt
  • Tandem fluorescent protein constructs
    Patent number: 5981200
    Abstract: This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic assays.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: November 9, 1999
    Assignees: The Regents of the University of California, Aurora Biosciences Corporation
    Inventors: Roger Y. Tsien, Roger Heim, Andrew Cubitt