Abstract: Wellbore synthesis techniques are disclosed suitable for use in geothermal applications. Embodiments are provided where open hole drilled wellbores are sealed while drilling to form an impervious layer at the wellbore/formation interface. The techniques may be chemical, thermal, mechanical, biological and are fully intended to irreversibly damage the formation in terms of the permeability thereof. With the permeability negated, the wellbore may be used to create a closed loop surface to surface geothermal well operable in the absence of well casing for maximizing thermal transfer to a circulating working fluid. Formulations for the working and drilling fluids are disclosed.

Abstract: The present disclosure provides methods of treating cancer, sterol homeostasis diseases, and neurological diseases using compounds which modulate the activity of sigma receptors. In particular, the present disclosure provides method s of modulating the sigma 2 receptor for use in treating one or more diseases associated with that sigma receptor.

Abstract: The invention provides a golf club head constructed from multiple components formed of different materials. In particular, a club head of the present disclosure includes a club head body, such as a cast or forged body portion, made from a first metal, and at least one removable component configured to be releasably attached to the club head body, the removable component being made from a second metal that is different than the first metal. The golf club head includes a semi-hollow, or completely hollow-bodied, ball-striking face cartridge made from at least titanium. In some embodiments, the hollow face cartridge may be integrally formed with the club head body. In other embodiments, the hollow face cartridge may be formed separately from the club head body and may be removed from and re-attached to the club head body.

Abstract: The invention relates to golf clubs, more particularly to mechanisms for fastening accessories to clubs. The invention provides a golf club configured to house an electronic device such as an RFID tag within a recess within the grip, thereby protecting the device from the stress, shock, and exposure that arises when a golf club is used.

Abstract: The invention provides a golf club head with a lid or cover enclosing a recess such as a channel for an adjustable weight. A golf club head can include a multi-position weight track or other channel or concavity to house a feature such as an adjustable weight mechanism. The club head has a lid that covers the channel, which—when closed—provides an outer surface of the golf club head that does not collect dirt or make whistling sounds when used and thus removes distractions and maintains the club head's intended weight distribution.

Abstract: In various embodiments, a hot melt device comprising a heating device that is automatically or manually triggered is configured so as to have its melt surface applied bringing a thermoplastic material in its solid form into contact with a surface via mechanical extrusion; using a heater to heat the thermoplastic material to a temperature above a melting temperature of the thermoplastic material while maintaining the contact of the thermoplastic material with the surface; allowing the heated thermoplastic material to cool to a temperature that is below the thermoplastic material's melting temperature; and allowing the heated thermoplastic material to bond the hot melt apparatus to the contacted surface without a solvent or use of a curing chemical reaction when the heated thermoplastic material is cooled to below the thermoplastic material's melting temperature while remaining connected to the structural body.

Abstract: The invention provides a golf club head constructed from multiple components formed of different materials. In particular, a club head of the present disclosure includes a club head body, such as a cast or forged body portion, made from a first metal, and at least one removable component configured to be releasably attached to the club head body, the removable component being made from a second metal that is different than the first metal. The golf club head includes a semi-hollow, or completely hollow-bodied, ball-striking face cartridge made from at least titanium. In some embodiments, the hollow face cartridge may be integrally formed with the club head body. In other embodiments, the hollow face cartridge may be formed separately from the club head body and may be removed from and re-attached to the club head body.

Abstract: Provided herein are SIRP-gamma, SIRP-beta or SIRP-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy, auto-immune disease, and viral infection.

Abstract: The invention generally relates to golf clubs with adjustable mass properties. In certain aspects, the invention provides methods and mechanisms for adjusting a club head center of gravity and/or moment of inertia by way of an adjustable weight assembly positionable along the sole of the club head body. When in a first position, the weight assembly provides a lower center of gravity so as to increase launch angle and reduce spin rate, resulting in greater overall distance of ball flight. When in a second position, the weight assembly provides a greater mass moment of inertia, which effectively enlarges the sweet spot and produces a more forgiving club for off-center hits.

Abstract: The invention relates to golf clubs, more particularly to mechanisms for fastening accessories to clubs. The invention provides a golf club configured to house an electronic device such as an RFID tag within a recess within the grip, thereby protecting the device from the stress, shock, and exposure that arises when a golf club is used.

Abstract: The invention provides a golf club head with a fully removable component that can withstand the stress of repeated hits. When assembled, the removable component is held in place by a fastening mechanism that includes structural elements that distribute the holding force across the component and tend to equalize the forces around the periphery where the component meets the body. The fastening mechanism may include a post that reaches across the open space within the hollow club head, pulling the removable component towards an opposed main club head body. Since a golf club of the present invention can be opened, it may include a mechanism on the inside for use by a golfer, such as an electronic device or an adjustment mechanism. The golf club may include a weight adjustment system that allows the club to be custom-fitted to a golfer.

Abstract: The invention provides a golf club head that includes a weight adjustment system inside of the club head. Preferably, when the club is played, no part of the adjustment system is directly accessible or exposed to an exterior of the club. The club head may include a panel that opens or is removable, or the club head may be disassembled to provide access to the internal weight adjustment system. A weight adjustment system generally includes at least one mechanism by which a mass distribution of the golf club head can be changed.

Abstract: The invention relates to golf clubs, more particularly to mechanisms for fastening accessories to clubs. The invention provides a golf club configured to house an electronic device such as an RFID tag within a recess within the grip, thereby protecting the device from the stress, shock, and exposure that arises when a golf club is used.

Abstract: Provided herein are SIRP-gamma, SIRP-beta or SIRP-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy, auto-immune disease, and viral infection.

Abstract: The invention relates to golf clubs, more particularly to mechanisms for fastening accessories to clubs. The invention provides a golf club configured to house an electronic device such as an RFID tag within a recess within the grip, thereby protecting the device from the stress, shock, and exposure that arises when a golf club is used.

Abstract: The invention provides a golf club head with an opening covered from within by a lightweight cap. The opening can be part of, e.g., a weight track. The club head includes a crown, sole, face, and hosel cooperating to define a hollow club head body comprising at least a first material. The club head has an opening through the hollow body. Part of an edge around the opening is provided by a first material and a cap member of a second material less dense than the first material is mounted e.g., by an adhesive to an inside surface of the hollow body and enclosing the opening. The described construction is easier to mold or cast that other forms featuring undercuts and does not unduly interfere with a club head center of gravity.

Abstract: The invention generally relates to golf clubs with adjustable mass properties. In certain aspects, the invention provides methods and mechanisms for adjusting a club head center of gravity and/or moment of inertia by way of an adjustable weight assembly positionable along the sole of the club head body. When in a first position, the weight assembly provides a lower center of gravity so as to increase launch angle and reduce spin rate, resulting in greater overall distance of ball flight. When in a second position, the weight assembly provides a greater mass moment of inertia, which effectively enlarges the sweet spot and produces a more forgiving club for off-center hits.

Abstract: The invention provides a golf club head that includes a weight adjustment system inside of the club head. Preferably, when the club is played, no part of the adjustment system is directly accessible or exposed to an exterior of the club. The club head may include a panel that opens or is removable, or the club head may be disassembled to provide access to the internal weight adjustment system. A weight adjustment system generally includes at least one mechanism by which a mass distribution of the golf club head can be changed.

Abstract: The invention relates to golf clubs, more particularly to mechanisms for fastening accessories to clubs. The invention provides a golf club configured to house an electronic device such as an RFID tag within a recess within the grip, thereby protecting the device from the stress, shock, and exposure that arises when a golf club is used.

Abstract: Provided herein are SIRP-gamma, SIRP-beta or SIRP-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy, auto-immune disease, and viral infection.