Abstract: A fluid connection device includes a first connector having at least one fluid passage and a second connector having at least one fluid passage. The second connector includes a sealing door that may be opened and closed for sealing the fluid passage when the first connector and the second connector are disconnected. The first connector includes a mechanical or electronic key for actuating the second connector, such that the sealing door opens in response to the key. When the sealing door is opened, the first connector may be joined with the second connector. When the first connector is fully joined with the second connector, the fluid passages may be adjacently aligned and in fluid communication for fluid flow therebetween.