Patents by Inventor Andrew David Pris
Andrew David Pris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210123010Abstract: A device and method for detecting the level of foam in a reactor vessel monitors the intensity of the light or the movement of the light detected by a camera which monitors at least one light source positioned inside the reactor vessel or viewable through the reactor vessel.Type: ApplicationFiled: August 28, 2017Publication date: April 29, 2021Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: KLAUS GEBAUER, PIERRE LE GREVES, ANDREW DAVID PRIS, JOZSEF VASI, SAM PETROCELLI, HANNO EHRING, ESMAEIL HEIDARI, ALI CAN
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Patent number: 10989709Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: GrantFiled: March 22, 2017Date of Patent: April 27, 2021Assignee: CYTIVA SWEDEN ABInventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray
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Patent number: 10359419Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.Type: GrantFiled: October 2, 2013Date of Patent: July 23, 2019Assignee: General Electric CompanyInventors: Anthony John Murray, Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj
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Patent number: 9828599Abstract: Methods for selecting a binding-element are provided. The method comprised of different steps. A first mixture is formed using at least one target molecule and a plurality of oligomers, followed by incubating the first mixture to form a second mixture comprising at least one target-bound oligomer and at least one target-unbound oligomer. Then a first accelerator is added to cleave the target-unbound oligomer and the target-bound oligomer is separated from the target molecule. This is followed by addition of a second accelerator for ligation, and a third accelerator for amplification followed by sequencing and post sequence analysis to select the binding-element.Type: GrantFiled: September 18, 2013Date of Patent: November 28, 2017Assignee: General Electric CompanyInventors: Nandini Nagraj, Radislav Alexandrovich Potyrailo, Andrew David Pris, John Richard Nelson
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Publication number: 20170267716Abstract: Provided herein are aptamer-polymer conjugates which are responsive to environmental stimuli and are useful in selective purification of untagged target polypeptides.Type: ApplicationFiled: March 16, 2016Publication date: September 21, 2017Inventors: Anthony John Murray, Andrew David Pris, Erik Leeming Kvam, Nandini Nagraj, Eugene Pauling Boden, Ernest William Kovacs, Louisa Ruth Carr, Rui Chen, Tiberiu Mircea Siclovan, Kelly Scott Chichak
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Publication number: 20170191992Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: ApplicationFiled: March 22, 2017Publication date: July 6, 2017Inventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray
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Publication number: 20150093820Abstract: A method of recovering a target from a sample is provided. The method comprises the adding a substrate coupled binding element to the sample comprising the target to form a substrate coupled binding element-target complex; precipitating the complex by changing one or more environmental conditions of the substrate and recovering the target and the substrate coupled binding-element under mild conditions.Type: ApplicationFiled: October 2, 2013Publication date: April 2, 2015Applicant: General Electric CompanyInventors: Anthony John Murray, Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj
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Publication number: 20150093839Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.Type: ApplicationFiled: October 2, 2013Publication date: April 2, 2015Applicant: General Electric CompanyInventors: Radislav Alexandrovich Potyrailo, Andrew David Pris, Nandini Nagraj, Anthony John Murray
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Publication number: 20150080226Abstract: Methods for selecting a binding-element are provided. The method comprised of different steps. A first mixture is formed using at least one target molecule and a plurality of oligomers, followed by incubating the first mixture to form a second mixture comprising at least one target-bound oligomer and at least one target-unbound oligomer. Then a first accelerator is added to cleave the target-unbound oligomer and the target-bound oligomer is separated from the target molecule. This is followed by addition of a second accelerator for ligation, and a third accelerator for amplification followed by sequencing and post sequence analysis to select the binding-element.Type: ApplicationFiled: September 18, 2013Publication date: March 19, 2015Applicant: General Electric CompanyInventors: Nandini Nagraj, Radislav Alexandrovich Potyrailo, Andrew David Pris, John Richard Nelson
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Publication number: 20130135617Abstract: A transducer includes a source of electromagnetic radiation, a substrate having a plurality of flow through passages and a receiver. The plurality of nanoparticles is disposed on the substrate and includes a material having a dielectric constant being arranged to support a photonically excited Plasmon in response to electromagnetic radiation from the source. The receiver measures the electromagnetic radiation and is disposed in optical communication with the substrate.Type: ApplicationFiled: November 30, 2011Publication date: May 30, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Andrew David PRIS, Windsor Paige OSBERG, Radislav Alexandrovich POTYRAILO
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Patent number: 8318099Abstract: Embodiments of the invention include a wireless sensor, such as an RFID tag, that includes a substrate, an antenna disposed on the substrate, and an environmentally sensitive sensor material disposed over at least a portion of said substrate. Other embodiments an RFID tag and at least one antibody coupled to the RFID tag. The RFID tag includes a substrate, circuitry disposed on the substrate, and an antenna coupled to the substrate. The at least one antibody is capable of affecting the signals emanating from the RFID tag. Further embodiments include a detection system that includes a reader. Yet other embodiments include a method for detecting specific analytes. The method includes providing an RFID tag which emanates a first signal having a first frequency, and enabling the REID tag to emanate a second signal having a second frequency upon attraction of a specific analyte to the RFID tag.Type: GrantFiled: October 26, 2005Date of Patent: November 27, 2012Assignee: General Electric CompanyInventors: Radislav Alexandrovich Potyrailo, William Guy Morris, Kenneth Brakeley Welles, II, Andrew Michael Leach, Andrew David Pris
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Publication number: 20100279272Abstract: Methods are described for performing a multiplexed analysis of a level of target analyte in a sample, employing an identifier and a labeling reagent. Either or both of the identifier and the labeling reagent comprises a SERS-active nanoparticle associated with a SERS-active reporter with a uniquely identifiable spectroscopic signature. Interrogation of the identifier and the labeling reagent is conducted by serial coincident detection. Such methods can provide enhanced multiplexed analysis of analytes in a sample, especially with regards to improving the type of identifying reagents that are employed.Type: ApplicationFiled: February 13, 2008Publication date: November 4, 2010Inventors: Michael Craig Burrell, John Yupeng Gui, Frank John Mondello, Andrew David Pris, Tracy Lynn Paxon
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Publication number: 20100129787Abstract: Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or vapor phase detection methods.Type: ApplicationFiled: November 21, 2008Publication date: May 27, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Andrew David Pris, Frank John Mondello
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Publication number: 20100129795Abstract: Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or vapor phase detection methods.Type: ApplicationFiled: November 21, 2008Publication date: May 27, 2010Applicant: General Electric CompanyInventors: Andrew David Pris, Tracy Lynn Paxon, Anthony John Murray
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Publication number: 20100129785Abstract: Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or vapor phase detection methods.Type: ApplicationFiled: November 21, 2008Publication date: May 27, 2010Applicant: General Electric CompanyInventors: Andrew David Pris, Tracy Lynn Paxon, Ronald James Wroczynski, Anthony John Murray
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Publication number: 20100129786Abstract: Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or vapor phase detection methods.Type: ApplicationFiled: November 21, 2008Publication date: May 27, 2010Applicant: General Electric CompanyInventors: Andrew David Pris, Frank John Mondello
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Patent number: 7615780Abstract: Disclosed herein are biosensors and methods for making and using the same. In one embodiment, the sensor for detecting an analyte comprises: a substrate, recognition elements specific for the analyte, an excitation source, a detector, a chamber located between the substrate and the excitation source and between the substrate and the detector, and an emission filter. The recognition elements are tethered to the substrate such that the recognition elements can be exposed to a sample. The excitation source is capable of emitting a first light having a first light peak intensity at a first wavelength, wherein the first light can excite a luminophore to emit a second light when the recognition elements interact with the analyte. The detector is capable of detecting the second light emitted by the luminophore. The emission filter is capable of filtering in a band gap that includes the first light peak intensity.Type: GrantFiled: June 29, 2006Date of Patent: November 10, 2009Assignee: General Electric CompanyInventors: Steven Alfred Tysoe, Eugene Barash, Andrew David Pris
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Publication number: 20090203149Abstract: Processes for improved efficiencies as it relates to the analysis of small molecules whose concentration in the analysis solution is dependent upon the concentration of a target as determined through a liquid phase biological assays with vapor and/or gas phase analysis are disclosed. The process generally includes the competitive or non-competitive binding of target substances onto carrier particles functioning as substrates in the biological assay. Employing the carrier particles as substrates provides increased surface area for the reaction to occur; increased ease of washing steps; and allows for concentration of the increased surface area into a smaller reaction volume prior to introduction into the vapor and/or gas phase spectrometer such as an ion mobility spectrometer.Type: ApplicationFiled: February 13, 2008Publication date: August 13, 2009Applicant: GENERAL ELECTRIC COMPANYInventor: Andrew David Pris
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Publication number: 20090137058Abstract: A device and method for detecting the presence of one or more analytes, bound directly or indirectly to a binding substrate functionalized with a fluorophore, based on measurements of fluorescence and reflectivity. The device and methods comprise an excitation source that emits light capable of being absorbed by a fluorophore and results in the fluorophore's excitation and emission, a fluorescent probe specific for the analyte that is attached via chemisorption to the binding substrate, a detector, and a processor adapted to determine the quantity of the one or more analytes present, by correlating measurements of reflected and fluorescent light.Type: ApplicationFiled: November 28, 2007Publication date: May 28, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Eugene Barash, Andrew David Pris
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Patent number: 7518721Abstract: A lateral flow device is disclosed. The lateral flow device includes a substrate having a flow path and a detection zone disposed along the flow path. The detection zone includes an immobilized target-binding moiety directed against a target of a Raman-active complex. Also disclosed is a method of conducting a lateral flow assay and detection system. The method includes i) defining a flow path having a detection zone; ii) flowing a sample down the flow path; and iii) immobilizing a Raman-active complex if present, at the detection zone. The sample includes a Raman-active complex or a Raman-active tag.Type: GrantFiled: September 9, 2005Date of Patent: April 14, 2009Assignee: GE Homeland Protection, Inc.Inventors: Michael Craig Burrell, Frank J. Mondello, Yuan-Hsiang Lee, Patrick Ronald Engel, Andrew David Pris