Abstract: A cellulosic inclusion-thermoplastic composition that includes cellulosic inclusions and a thermoplastic polyolefin that forms a matrix in which the cellulosic inclusions are dispersed. A maleated polymer and a polar thermoplastic polymer resin of a polyamide or polyester are provided to improve adhesion between the cellulosic inclusions and the thermoplastic polyolefin. The polar thermoplastic polymer resin is characterized by a melting temperature greater than that of the thermoplastic polyolefin. The composition as provided has increased break tensile strength relative to a composition devoid of the polar thermoplastic polymer resin but otherwise is unchanged. The break tensile is measured at 23° Celsius and at an elongation rate of 50 millimeters per minute.

Abstract: A high speed debug support interface has circuits to interface on-chip debug support circuits to a high bandwidth communications port means located on the surface of a system integrated circuit (101) and to on-chip debug support circuits (100). The communication port means can be realised by bonding or integrating special sender and or receiver cells preferably optical sender cells (103) and or optical receiver cells (110) onto the surface of the system integrated circuit (101). The high speed debug support interface communicates with on-chip or in-assembly debug support circuits and an external development tool (108) to permit hardware and software related debugging and development activities, including program tracing, data tracing and memory substitution. The high speed debug support interface has circuits to interface on-chip debug support circuits to system resources such as memory located within the device assembly (102) and connected by the system interconnect.

Abstract: The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. Also contemplated by the present invention are crystals of PDE5/PDE5 inhibitor complexes.

Abstract: The present invention relates to the soakable crystals of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 ligands and inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. The present invention additionally relates to crystals of PDE5 into which ligands may be soaked and crystals of PDE5 comprising PDE5 ligands that have been soaked into the crystal.

Abstract: A pharmaceutical knowledge base is provided that contains multiple information items stored in at least one computer. Pharmaceutical knowledge is represented in a multi-dimensional coordinate space having at least first, second and third axes, where the first axis pertains to diseases, the second axis pertains to targets, and the third axis pertains to drug compounds. Pharmaceutical knowledge may be mapped into the multi-dimensional coordinate space by assigning each information item one or more locations in the space, dependent upon the data contained within the information item. This mapping may then be used to reveal hitherto unappreciated connections between the axes, such as the potential use of a particular compound or target for treating a certain disease.

Abstract: A regenerative photoelectrochemical (RPEC) device comprising two substrates, wherein: one or both substrates are transparent and are coated with transparent electrical conductor (TEC) layer; one or more layers of porous wide band gap semiconductor is/are applied to selected area of said TEC layer and sensitised with dye; electrolyte is placed between said two substrates; hole(s) made in one or both said substrates to enable external electrical connection(s) to said RPEC device.

Abstract: The present invention relates to manufacturing of regenerative photovolatic photoelectrochemical (RPEC) devices. The invention describes a method for manufacturing RPEC devices in a production line. The method comprises the steps of: dispensing a protective film in a substantially continuous sheet; attaching at least one substrate to the protective film in such a way that predetermined areas of the substrate are protected from being coated during at least one subsequent manufacturing process; using the protective films as a means to transport the substrate, along the production line through the at least one subsequent manufacturing process.

Abstract: A system and method for guiding a business after an initial funding state to an initial public offering (“IPO”) readiness state. A first stage approach launches the business and a second stage approach is performed for at least one of maturing the business and guiding the business to an IPO readiness state. The first stage approach readies the company for launch, focusing on moving quickly to market, defining expectations, attracting customers, building a brand, building alliances, creating disposable solutions, and investing resources. The second stage approach grows and matures the company, focusing on capturing the market, expanding expectations, retaining customers, attracting new customers, expanding alliances, creating effective solutions, and making money.

Abstract: The present invention relates to multi-cell regenerative photovoltaic photoelectrochemical (RPEC) devices. The invention describes the structure of a multi-cell RPEC device where conductive interconnects are formed by a matrix mounting conductive particles, formed between extended portions of opposed planar conductive members.