Patents by Inventor Andrew Horti

Andrew Horti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DREADD actuators
    Patent number: 11739063
    Abstract: Disclosed is a compound of formula (I) in which R1, R2, and R3 are as described herein. Also provided are pharmaceutical compositions comprising the compound of formula (I) and methods of using the compound of formula (I), including a method of treating a disease or disorder and a method for effectuating a G-protein coupled receptor (GPCR)-mediated response in a subject.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: August 29, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Johns Hopkins University
    Inventors: Jordi Bonaventura, Juan Luis Gomez, Andrew Horti, Feng Hu, Michael Michaelides, Martin Pomper, Marta Sanchez-Soto
  • F-FNDP for pet imaging of soluble epoxide hydrolase (sEH)
    Patent number: 10912850
    Abstract: Radiofluorinated FNDP for PET imaging of soluble epoxide hydrolase (sEH) and method of using the same are disclosed.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: February 9, 2021
    Assignees: The Johns Hopkins University, Oregon Health & Science University
    Inventors: Andrew Horti, Martin G. Pomper, Nabil J. Alkayed
  • DREADD ACTUATORS
    Publication number: 20200399228
    Abstract: Disclosed is a compound of formula (I) in which R1, R2, and R3 are as described herein. Also provided are pharmaceutical compositions comprising the compound of formula (I) and methods of using the compound of formula (I), including a method of treating a disease or disorder and a method for effectuating a G-protein coupled receptor (GPCR)-mediated response in a subject.
    Type: Application
    Filed: February 6, 2019
    Publication date: December 24, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, The Johns Hopkins University
    Inventors: Jordi Bonaventura, Juan Luis Gomez, Andrew Horti, Feng Hu, Michael Michaelides, Martin Pomper, Marta Sanchez-Soto
  • 18F-FNDP FOR PET IMAGING OF SOLUBLE EPOXIDE HYDROLASE (sEH)
    Publication number: 20190134235
    Abstract: Radiofluorinated FNDP for PET imaging of soluble epoxide hydrolase (sEH) and method of using the same are disclosed.
    Type: Application
    Filed: May 4, 2017
    Publication date: May 9, 2019
    Inventors: ANDREW HORTI, MARTIN G. POMPER, NABIL J. ALAYED
  • DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS
    Publication number: 20170296682
    Abstract: The presently disclosed subject matter provides non-invasive methods for imaging, quantifying ?7 nicotinic cholinergic receptors, and diagnosing a disease or condition associated with ?7-nAChRs. Methods for preparing radiolabeled derivatives of dibenzothiophene and compounds provided thereof also are provided.
    Type: Application
    Filed: May 3, 2017
    Publication date: October 19, 2017
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Yongjun Gao, Andrew Horti, Robert Dannals, Richard Wahl, Ronnie Mease, Ken Kellar, Paige Finley, Martin Pomper
  • DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS
    Publication number: 20160235869
    Abstract: The presently disclosed subject matter provides non-invasive methods for imaging, quantifying ?7 nicotinic cholinergic receptors, and diagnosing a disease or condition associated with ?7-nAChRs. Methods for preparing radiolabeled derivatives of dibenzothiophene and compounds provided thereof also are provided.
    Type: Application
    Filed: February 13, 2015
    Publication date: August 18, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Yongjun Gao, Andrew Horti, Robert Dannals, Richard Wahl, Ronnie Mease, Ken Kellar, Paige Finley, Martin Pomper
  • Radiolabeled pyridyl-7-azabicyclo[2,2,1]heptanes
    Patent number: 5969144
    Abstract: The present invention is directed to radiolabeled epibatidine analogues, specifically FPH labeled with radioisotopes of fluorine and/or carbon. These radiolabeled epibatidine compounds are used to noninvasively image and quantify nicotinic cholinergic receptors in the living brain for both research studies and the diagnosis of neurodegenerative diseases.
    Type: Grant
    Filed: December 1, 1997
    Date of Patent: October 19, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Edythe D. London, Alane S. Kimes, Andrew Horti, Robert F. Dannals, Michael Kassiou
  • Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo ?2.2.1!heptanes
    Patent number: 5726189
    Abstract: The present invention is directed to radiolabeled epibatidine analogues, specifically FPH labeled with radioisotopes of fluorine and/or carbon. These radiolabeled epibatidine compounds are used to noninvasively image and quantify nicotinic cholinergic receptors in the living brain for both research studies and the diagnosis of neurodegenerative diseases.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: March 10, 1998
    Assignees: The United States of America, represented by The Secretary, Department of Health and Human Services, Johns Hopkins University School of Medicine
    Inventors: Edythe D. London, Alane S. Kimes, Andrew Horti, Robert F. Dannals, Michael Kassiou