Abstract: Methods for making, identifying, isolating and/or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.

Abstract: A system and method are provided for maintaining state synchronization between a primary device and a secondary device. The present method includes the steps of generating a sequence identifier in the primary device, attaching the sequence identifier to a message in the primary device, transmitting the message and the sequence identifier attached thereto to the secondary device, and storing the sequence identifier in the secondary device as a secondary sequence identifier. In addition, the method includes the step of comparing a secondary sequence identifier from the secondary device with the sequence identifier in the primary device to detect a lost message.

Abstract: A system and method are provided for maintaining a common consistent database in a primary device and in a secondary device. The method includes the steps of determining a need for a merger of a first database maintained in the primary device and a second database maintained in the secondary device, the first and second databases being derived from common database. The method also includes the steps of merging the first database and the second database, resulting in a merged database and assigning a sequence identifier to the merged database. Finally the present method includes the step of synchronizing the merged database in the primary and secondary devices.

Abstract: In connection with an electronic reading/annotation device, a method for automatically selecting between an electronic writing pen tool used for handwriting tasks and an electronic marker tool used for highlighting tasks is provided. Whereas handwriting normally consists of small radius curves, and frequent changes of direction, highlighting strokes are normally long and smooth with hardly ever a change of direction. The automatic selection method utilizes analysis of the shape of each stroke. More specifically, the length of each stroke is calculated between a starting point and a later made point of the stroke. If the length of the stroke is close to that of a straight line between the same two points and the stroke is determined not to be a handwriting stroke, the highlighting function is automatically selected. The exact determination of “close” is a tunable parameter.