Abstract: This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.

Abstract: A first input to a mobile device indicates a first navigation destination at a first level of specificity. The mobile device initiates navigation towards a first location corresponding to the first navigation destination. While navigation towards the first location corresponding to the first navigation destination is ongoing and before reaching the first location, in accordance with a determination that one or more first criteria are satisfied, the mobile device prompts for an input for determination a second location corresponding to a second navigation destination with a second level of specificity, the second level of specificity more specific than the first level of specificity. The mobile device receives a second input in response to the prompt. In accordance with a determination that the second input satisfies one or more second criteria, the mobile device initiates navigation towards the second location corresponding to the second navigation destination.

Abstract: The present invention provides apelin receptor (APLNR) modulators that bind to APLNR and methods of using the same. The invention includes APLNR modulators such as antibodies, or antigen-binding fragments thereof, which inhibit or attenuate APLNR-mediated signaling. The invention includes APLNR modulators such as antibodies, or antibody fusion proteins thereof, that activate APLNR-mediated signaling. According to certain embodiments of the invention, the antibodies or antigen-binding fragments or antibody fusion proteins are fully human antibodies that bind to human APLNR with high affinity. The APLNR modulators of the invention are useful for the treatment of diseases and disorders associated with APLNR signaling and/or APLNR cellular expression, such as cardiovascular diseases, angiogenesis diseases, metabolic diseases and fibrotic diseases.

Abstract: The invention relates to computer-implemented systems and methods for implementing a verified digital asset platform. An embodiment of the present invention is directed to enabling companies to provide professional recognition awards to employees utilizing digital assets, such as NFT (Non-Fungible Tokens). With an embodiment of the present invention, a digital wallet may store public and private keys and allow the owner to perform various actions including access assets, manage assets and sign transactions.

Abstract: A method of matching carriers to shippers is described. In an embodiment, the method comprises the steps of receiving carrier capacity data from a plurality of linked sources into a transportation database in a data processing system, wherein the carrier capacity data comprises a parameter for each linked source; saving the carrier capacity data; receiving a request for a requested route into the data processing system, wherein the request includes request data; comparing the parameter of each linked source to the request data; determining if the parameter of at least one linked source matches the request data; displaying a matched route for each at least one linked source for which the parameter matches the request data; and displaying each matched route on a graphical user interface.

Abstract: An endoluminal prosthesis having an unsupported or flexible region and a delivery system for delivering the endoluminal prosthesis is provided. The delivery system includes a prosthesis delivery catheter with stiffening elements that provide longitudinally rigid support to a flexible or unsupported portion of an endoluminal prosthesis as the prosthesis is being deployed. A prosthesis is removably coupled to the stiffening elements. The endoluminal prosthesis can be a stent or a stent graft or graft.

Abstract: An endoluminal prosthesis having an unsupported or flexible region and a delivery system for delivering the endoluminal prosthesis is provided. The delivery system includes a prosthesis delivery catheter with stiffening elements that provide longitudinally rigid support to a flexible or unsupported portion of an endoluminal prosthesis as the prosthesis is being deployed. A prosthesis is removably coupled to the stiffening elements. The endoluminal prosthesis can be a stent or a stent graft or graft.