Patents by Inventor Andrew J. Prongay

Andrew J. Prongay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factor IXa crystals, related complexes and methods
    Patent number: 8710188
    Abstract: The present invention relates to factor IXa complexes and crystals thereof as well as methods for identifying inhibitors of factor IXa.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: April 29, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Brian M. Beyer, Alan W. Hruza, Richard N. Ingram, Vincent S. Madison, Andrew J. Prongay, Paul Reichert
  • Factor IXa Crystals, Related Complexes and Methods
    Publication number: 20130157281
    Abstract: The present invention relates to factor IXa complexes and crystals thereof as well as methods for identifying inhibitors of factor IXa.
    Type: Application
    Filed: May 31, 2011
    Publication date: June 20, 2013
    Applicant: SCHERING CORPORATION
    Inventors: BRIAN M. BEYER, ALAN W. HRUZA, RICHARD N. INGRAM, VINCENT S. MADISON, ANDREW J. PRONGAY, PAUL REICHERT
  • ASSAY FOR PCSK9 INHIBITORS
    Publication number: 20120214181
    Abstract: The present invention provides methods for identifying modulators of PCSK9, for example, using a variety of assay formats. Inhibitors of PCSK9 can be used for example, to treat diseases such as hyperlipidemia and related disorders.
    Type: Application
    Filed: May 8, 2012
    Publication date: August 23, 2012
    Inventors: Brian M. Beyer, Thomas Hesson, Hung V. Le, Andrew J. Prongay, Krishna Kalghatgi, Jennifer Joanne Gesell, Richard N. Ingram, Michael R. Ziebell
  • Assay for PCSK9 inhibitors
    Patent number: 8206943
    Abstract: The present invention provides methods for identifying modulators of PCSK9, for example, using a variety of assay formats. Inhibitors of PCSK9 can be used for example, to treat diseases such as hyperlipidemia and related disorders.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: June 26, 2012
    Assignee: Schering Corporation
    Inventors: Brian M. Beyer, Thomas Hesson, Hung V. Le, Andrew J. Prongay, Krishna Kalghatgi, Jennifer Joanne Gesell, Richard N. Ingram, Michael R. Ziebell
  • Kinase domain polypeptide of human protein kinase B gamma (AKT3)
    Patent number: 8088611
    Abstract: The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: January 3, 2012
    Assignee: Schering Corp.
    Inventors: Andrew J. Prongay, Thierry O. Fischmann, Chandra C. Kumar, Vincent S. Madison, Joseph E. Myers, Paul Reichert, Rosalinda Syto, William T. Windsor, Li Xiao, Todd W. Mayhood
  • Factor IXa crystals, related complexes and methods
    Patent number: 7968683
    Abstract: The present invention relates to factor IXa complexes and crystals thereof as well as methods for identifying inhibitors of factor IXa.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: June 28, 2011
    Assignee: Schering Corporation
    Inventors: Brian M. Beyer, Alan W. Hruza, Richard N. Ingram, Vincent S. Madison, Andrew J. Prongay, Paul Reichert
  • AKT3 POLYPEPTIDES
    Publication number: 20100267053
    Abstract: The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
    Type: Application
    Filed: May 21, 2010
    Publication date: October 21, 2010
    Applicant: Schering Corporation
    Inventors: ANDREW J. PRONGAY, Thierry O. Fischmann, Chandra Kumar, Vincent S. Madison, Joseph E. Myers, Paul Reichert, Rosalinda Syto, William T. Windsor, Li Xiao, Todd W. Mayhood
  • Polynucleotides encoding polypeptide fragments of protein kinase B gamma (AKT3)
    Patent number: 7776589
    Abstract: The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: August 17, 2010
    Assignee: Schering Corporation
    Inventors: Andrew J. Prongay, Thierry O. Fischmann, Chandra Kumar, Vincent S. Madison, Joseph E. Myers, Paul Reichert, Rosalinda Syto, William T. Windsor, Li Xiao, Todd W. Mayhood
  • Substituted indazoles of formula 1.0 that are kinase inhibitors
    Patent number: 7700601
    Abstract: Disclosed is a compound of the formula: and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating protein kinase mediated diseases using the compound of formula 1.0. Also disclosed are methods of treating cancer using a compound of formula 1.0. The disclosed methods also include combination therapies wherein the compound of formula 1.0 is administered in combination with at least one addition pharmaceutically active ingredient.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: April 20, 2010
    Assignee: Schering Corporation
    Inventors: Tin-Yau Chan, Brian A. McKittrick, Haiyan Pu, Liwu Hong, Andrew J. Prongay, Li Xiao, Mark A. McCoy
  • Kinase inhibitors
    Patent number: 7528132
    Abstract: A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as immunodeficiencies, cancers, cardiovascular diseases, endocrine disorders, Parkinson's disease, metabolic diseases, tumorigenesis, Alzheimer's disease, heart disease, diabetes, neurodegeneration, inflammation, kidney disease, atherosclerosis and airway disease.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: May 5, 2009
    Assignee: Schering Corporation
    Inventors: Tin-Yau Chan, Thierry O. Fischmann, Mark A. McCoy, Brian A. McKittrick, Andrew J. Prongay, Haiyan Pu, Li Wang, Li Xiao
  • Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
    Publication number: 20020016294
    Abstract: The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: April 17, 2001
    Publication date: February 7, 2002
    Inventors: Srikanth Venkatraman, Kevin X. Chen, Ashok Arasappan, F. George Njoroge, Viyyoor M. Girijavallabhan, Tin-Yau Chan, Brian A. Mc Kittrick, Andrew J. Prongay, Vincent S. Madison