Patents by Inventor Andrew James Greenland
Andrew James Greenland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7183061Abstract: The invention relates to an insect steroid receptor protein which is capable of acting as a gene switch which is responsive to a chemical inducer enabling external control of the gene.Type: GrantFiled: June 25, 2003Date of Patent: February 27, 2007Assignee: Syngenta LimitedInventors: Ian Jepson, Alberto Martinez, Andrew James Greenland
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Publication number: 20040157287Abstract: The present invention relates to novel AlcR regulatory elements and nucleic acid sequences coding therefor, and their use in controlling gene expression in organisms such as plants. DNA constructs containing such nucleic acids, in particular, expression cassettes comprising inducible promoter elements and regulatory elements of the invention, which are capable of acting as “gene switches”, form further aspects of the invention.Type: ApplicationFiled: August 11, 2003Publication date: August 12, 2004Inventors: Andrew James Greenland, Ian Jepson, Alberto Martinez, Lynne Marie Roxbee Cox
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Publication number: 20040058369Abstract: The invention relates to an insect steroid receptor protein which is capable of acting as a gene switch which is responsive to a chemical inducer enabling external control of the gene.Type: ApplicationFiled: June 25, 2003Publication date: March 25, 2004Inventors: Ian Jepson, Alberto Martinez, Andrew James Greenland
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Publication number: 20040045053Abstract: A recombinant nucleic acid which comprises a promoter sequence of the ZmC5 gene in maize, or a variant or fragment thereof, which acts as a promoter in pollen.Type: ApplicationFiled: December 5, 2002Publication date: March 4, 2004Inventors: Andrew James Greenland, Hilary Joan Rogers, Patrick Joseph Hussey
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Patent number: 6610828Abstract: The invention relates to an insect steroid receptor protein which is capable of acting as a gene switch which is responsive to a chemical inducer enabling external control of the gene.Type: GrantFiled: May 3, 2000Date of Patent: August 26, 2003Assignee: Syngenta LimitedInventors: Ian Jepson, Alberto Martinez, Andrew James Greenland
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Patent number: 6599514Abstract: Antifungal compositions having enhanced antifungal activity comprising an antifungal agent and a food additive are described. Also described are a method for inhibiting fungal growth using the compositions with enhanced activity and the use of a food additive to enhance the antifungal properties of an antifungal agent.Type: GrantFiled: December 21, 1999Date of Patent: July 29, 2003Assignee: Syngenta LimitedInventors: Andrew James Greenland, Angel Manuel Fuentes Mateos
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Patent number: 6379945Abstract: The invention relates to an insect steroid receptor protein which is capable of acting as a gene switch which is responsive to a chemical inducer enabling external control of the gene.Type: GrantFiled: May 24, 1996Date of Patent: April 30, 2002Assignee: Zeneca LimitedInventors: Ian Jepson, Alberto Martinez, Andrew James Greenland
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Publication number: 20010049833Abstract: Disclosed are isolated DNA constructs including (a) a first DNA sequence including either an inducible promoter sequence responsive to the presence or absence of an exogenous inducer or a developmental gene promoter capable of initiating gene expression in a selected tissue or at a selected stage of development of an organism; (b) a second DNA sequence including a DNA sequence coding for a protease enzyme operably linked and under the control of the promoter sequence specified at (a); whereby the presence or absence of the exogenous inducer or the activation of the developmental gene promoter specified at (a) results in expression of the protease enzyme. These constructs are preferably rendered reversible by the presence of further elements. These constructs can be used in plant or mammalian cells for disruption of cell function, controlling senescence and modifying the metabolism of stored proteins.Type: ApplicationFiled: February 14, 2001Publication date: December 6, 2001Inventors: Andrew James Greenland, Didier Rene Philippe Thomas, Ian Jepson
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Patent number: 6228643Abstract: A promoter comprising the DNA sequence of an oil seed rape cysteine protease gene promoter of class 1, 2 or 6 is described. The promoter may be used in an expression system for at least the tissue or tissues of a germinating seedling or developing grain or plant (e.g. in the root, cotyledons, leaves and stem). In a preferred embodiment, the expression system comprises a disrupter gene fused to a promoter according to the present invention.Type: GrantFiled: March 22, 1997Date of Patent: May 8, 2001Assignee: Zeneca LimitedInventors: Andrew James Greenland, Didier Rene Philippe Thomas, Ian Jepson
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Patent number: 6172279Abstract: Male sterility is imparted to a plant by a cascade of gene sequences which expresses a protein which disrupts the biosynthesis of viable pollen. Expression of the disrupter protein is restricted to male parts of the plant by an upstream promoter sequence which is specific to male flowers, the male specific promoter being under control of an operator sequence. The cascade also includes a gene encoding a repressor protein specific for that operator. Expression of the repressor protein is under control of a chemically inducible promoter which is inducible by the application to the plant by, spraying or like process, of an exogenous chemical. In the absence of the exogenous chemical inducer, no repressor protein is expressed, resulting in expression of the disrupter protein and, consequently, male sterility.Type: GrantFiled: November 7, 1995Date of Patent: January 9, 2001Assignee: Zeneca LimitedInventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, Wolfgang Walter Schuch
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Patent number: 6066456Abstract: The chemically-inducible 27 kD subunit of the enzyme glutathione-S-transferase, isoform II (GST-II-27) and sequences encoding it are provided. In particular, a genomic DNA sequence encoding the gene promoter for the GST-II-27 subunit is provided. Then linked to an exogenous gene and introduced into a plant by transformation, and GST-II-27 promoter provides a means for the external regulation of expression of that exogenous gene. Transformation with DNA encoding glutathione-S-transferase polypeptides produces herbicide resistance transgenic plants.Type: GrantFiled: March 26, 1998Date of Patent: May 23, 2000Assignee: Zeneca LimitedInventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, David Charles Holt, Ian Jepson, Wolfgang Walter Schuch
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Patent number: 6037524Abstract: A promoter derived from an SHH gene, especially the SHH gene of Arabidopsis thaliana which is capable of directing expression on a variety of operator genes in both monocotyledonous and dicotyledonous plants. The promoter of the invention may be used for directing expression of pathogen resistance genes to disease or wound sites.Type: GrantFiled: October 9, 1997Date of Patent: March 14, 2000Assignee: Zeneca LimitedInventors: Andrew James Greenland, John Draper, Mark Skipsey, Simon Warner
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Patent number: 6010887Abstract: Pseudo-operator sequences may be located in (or inserted into) plant genomes and utilized to drive expression of foreign genes. These pseudo-operator sequences are nucleotide sequences which are present at a suitable location in a gene at which repressor binding will lead to inhibitation or enhancement of gene expression. The disclosed technique permits the design of altered specificity repressors, which bind the pseudo-operators.Type: GrantFiled: September 14, 1994Date of Patent: January 4, 2000Assignees: Imperial Chemical Industries PLC, University of LeicesterInventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, Wolfgang Walter Schuch, Andrew Merryweather, David Pioli
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Patent number: 5965387Abstract: A chemically inducible gene promoter sequence, and particularly, but not exclusively, a chemically inducible gene promoter sequence based on cis regulatory elements from the maize glutathione S-transferase 27 (GST-27) gene. In a preferred embodiment, the promoter sequence is operatively linked or fused to a gene or series of genes whereby expression of the gene or series of genes may be controlled by application of an effective exogenous inducer.Type: GrantFiled: September 23, 1996Date of Patent: October 12, 1999Assignee: Zeneca LimitedInventors: Ian Jepson, Andrew James Greenland, Michael Bevan, Hilary Sheppard
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Patent number: 5866792Abstract: The chemically-inducible 27 kD subunit of the enzyme glutathione-S-transferase, isoform II (GST-II-27) and sequences encoding it are provided. In particular, a genomic DNA sequence encoding the gene promoter for the GST-II-27 subunit is provided. Then linked to an exogenous gene and introduced into a plant by transformation, and GST-II-27 promoter provides a means for the external regulation of expression of that exogenous gene. Transformation with DNA encoding glutathione-S-transferase polypeptides produces herbicide resistance transgenic plants.Type: GrantFiled: June 17, 1996Date of Patent: February 2, 1999Assignee: Zeneca LimitedInventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, David Charles Holt, Ian Jepson, Wolfgang Walter Schuch
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Patent number: 5808034Abstract: Male sterility is imparted to a plant by a cascade of gene sequences which expresses a protein which disrupts the biosynthesis of viable pollen. Expression of the disrupter protein is restricted to male parts of the plant by an upstream promoter sequence which is specific to male flowers, the male specific promoter being under control of an operator sequence. The cascade also includes a gene encoding a repressor protein specific for that operator. Expression of the repressor protein is under control of a chemically inducible promoter which is inducible by the application to the plant by, spraying or like process, of an exogenous chemical. In the absence of the exogenous chemical inducer, no repressor protein is expressed, resulting in expression of the disrupter protein and, consequently, male sterility.Type: GrantFiled: August 22, 1994Date of Patent: September 15, 1998Assignee: Zeneca LimitedInventors: Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, Wolfgang Walter Schuch