Patents by Inventor Andrew John Cooke
Andrew John Cooke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230077499Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, and R4 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.Type: ApplicationFiled: December 16, 2020Publication date: March 16, 2023Applicant: Merck Sharp & Dohme LLCInventors: Kira A. Armacost, Andrew John Cooke, Robert Patrick Hayes, Marc A. Labroli, Michael Aaron Plotkin, Izzat Tiedje Raheem, Jeffrey W. Schubert, David M. Tellers
-
Publication number: 20230066268Abstract: The present invention relates to novel Indazole Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5 and R6 are as defined herein. The present invention also relates to compositions comprising at least one Indazole Derivative, and methods of using the Indazole Derivatives for treating or preventing a herpesvirus infection in a patient.Type: ApplicationFiled: December 15, 2020Publication date: March 2, 2023Applicant: Merck Sharp & Dohme LLCInventors: Andrew John Cooke, Christopher D. Cox, Scott D. Edmondson, Charles Lee Jayne, Anilkumar G. Nair, Jeffrey W. Schubert, Jason W. Skudlarek, David M. Tellers, De-Yi Yang
-
Publication number: 20230054782Abstract: The present invention relates to novel Bicyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5, R6, and R7 are as defined herein. The present invention also relates to compositions comprising at least one Bicyclic Heterocycle Compound, and methods of using the Bicyclic Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.Type: ApplicationFiled: December 17, 2020Publication date: February 23, 2023Applicant: Merck Sharp & Dohme LLCInventors: Andrew John Cooke, Brendan M. Crowley, Marc A. Labroli, Michael Aaron Plotkin, Izzat T. Raheem, Ling Tong, Deyou Sha
-
Patent number: 9522141Abstract: This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.Type: GrantFiled: December 17, 2013Date of Patent: December 20, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Scott B. Hoyt, Jerry Andrew Taylor, Clare London, Yusheng Xiong, Andrew John Cooke
-
Patent number: 9205520Abstract: A two-stage punch accomplishes the two-step process of sheet deformation and nut flaring to attach the nut to the sheet in a single stroke of an assembly press. The punch comprises an outer cylindrical sleeve which captivates a resiliently biased center punch. When the punch is moved downward into contact with the sheet, an embossing ring on the sleeve deforms the sheet material around an aperture in the sheet. When the punch is moved farther downward, a pointed end of the center punch extends beyond the embossing ring and into forcible contact with the nut. The nut is thereby flared capturing the sheet between flared edges of the nut and a nut flange.Type: GrantFiled: January 11, 2012Date of Patent: December 8, 2015Assignee: PEM Management, Inc.Inventor: Andrew John Cooke
-
Publication number: 20150320733Abstract: This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.Type: ApplicationFiled: December 17, 2013Publication date: November 12, 2015Applicant: Merck Sharp & Dohme Corp.Inventors: Scott B. Hoyt, Jerry Andrew Taylor, Clare London, Yusheng Xiong, Andrew John Cooke
-
Patent number: 9108939Abstract: The present invention relates to (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl derivatives having the general formula (I) to pharmaceutical compositions comprising the same and to the use of these (1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)phenyl derivatives in the treatment of atherosclerosis.Type: GrantFiled: October 26, 2010Date of Patent: August 18, 2015Assignee: Merck Sharp & Dohme B.V.Inventors: Andrew John Cooke, Emma Louise Carswell, David Jonathan Bennett
-
Patent number: 8759352Abstract: The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein R1 is (C1-8)alkyl, (C3-8)cycloalkyl or (C3-8)cycloalkyl(C1-3)alkyl, each of which may be substituted by hydroxy, cyano or halogen; R2 represents 1 or 2 optional halogens; R3 is (C1-6)alkyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl, each of which may be substituted by one or more halogens; A represents a heteroaryl ring system comprising 1-3 heteroatoms selected from N, O and S, which ring system is 5- or 6-membered when X is C, and 5-membered when X is N; n is 1 or 2; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same, and to the use of a these 1-(4-ureidobenzoyl)piperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterType: GrantFiled: August 26, 2009Date of Patent: June 24, 2014Assignees: Merck Sharp & Dohme B.V., Pharmacopeia LLC.Inventors: Andrew John Cooke, David Jonathan Bennett, Andrew Stanley Edwards, Andrew Laird Roughton, Irina Neagu, Jui-Hsiang Chan, Koc-Kan Ho, Nasrin Ansari, Michelle Lee Morris, Yajing Rong, Michael Ohlmeyer
-
Patent number: 8357679Abstract: The present invention relates to hexafluoroisopropanol derivatives having the general formula I to pharmaceutical compositions comprising the same and to the use of these hexafluoroisopropanol derivatives in the treatment of atherosclerosis.Type: GrantFiled: May 13, 2009Date of Patent: January 22, 2013Assignee: MSD Oss B.V.Inventors: Andrew John Cooke, Andrew Stanley Edwards, Fiona Elizabeth Andrews, David Jonathan Bennett, Olaf Nimz, Emma Louise Carswell
-
Patent number: 8314091Abstract: The present invention relates to N-benzyl,N?-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N?-arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.Type: GrantFiled: August 19, 2008Date of Patent: November 20, 2012Assignees: MSD OSS B.V., Pharmacopeia, Inc.Inventors: Koc-Kan Ho, Andrew Laird Roughton, Irina Neagu, Jui-Hsiang Chan, Nasrin Ansari, Michelle Lee Morris, Yajing Rong, Michael Ohlmeyer, Andrew John Cooke, Andrew Stanley Edwards, David Jonathan Bennett
-
Publication number: 20120238574Abstract: The present invention relates to (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl derivatives having the general formula (I) to pharmaceutical compositions comprising the same and to the use of these (1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)phenyl derivatives in the treatment of atherosclerosis.Type: ApplicationFiled: October 26, 2010Publication date: September 20, 2012Applicant: N.V. ORGANONInventors: Andrew John Cooke, Emma Louise Carswell, David Jonathan Bennett
-
Publication number: 20120180301Abstract: A two-stage punch accomplishes the two-step process of sheet deformation and nut flaring to attach the nut to the sheet in a single stroke of an assembly press. The punch comprises an outer cylindrical sleeve which captivates a resiliently biased center punch. When the punch is moved downward into contact with the sheet, an embossing ring on the sleeve deforms the sheet material around an aperture in the sheet. When the punch is moved farther downward, a pointed end of the center punch extends beyond the embossing ring and into forcible contact with the nut. The nut is thereby flared capturing the sheet between flared edges of the nut and a nut flange.Type: ApplicationFiled: January 11, 2012Publication date: July 19, 2012Applicant: PEM Management, Inc.Inventor: Andrew John Cooke
-
Publication number: 20120015958Abstract: The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein R1 is (C1-8)alkyl, (C3-8)cycloalkyl or (C3-8)cycloalkyl(C1-3)alkyl, each of which may be substituted by hydroxy, cyano or halogen; R2 represents 1 or 2 optional halogens; R3 is (C1-6)alkyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl, each of which may be substituted by one or more halogens; A represents a heteroaryl ring system comprising 1-3 heteroatoms selected from N, O and S, which ring system is 5- or 6-membered when X is C, and 5-membered when X is N; n is 1 or 2; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same, and to the use of a these 1-(4-ureidobenzoyl)piperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterType: ApplicationFiled: August 26, 2009Publication date: January 19, 2012Inventors: Andrew John Cooke, David Jonathan Bennett, Andrew Stanley Edwards, Andrew Laird Roughton, Irina Neagu, Jui-Hsiang Chan, Koc Kan Ho, Nasrin Ansari, Michelle Lee Morris, Yajing Rong, Michael Ohlmeyer
-
1,5,7-trisubstituted benzimidazole derivatives and their use for modulating the GABAreceptor complex
Patent number: 7700638Abstract: This invention relates to novel 1,5,7-trisubstituted benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex.Type: GrantFiled: October 20, 2004Date of Patent: April 20, 2010Assignees: N. V. Organon, Neurosearch A/SInventors: Niall Morton Hamilton, Susan Elizabeth Napier, Morag Ann MacCall Easson, Andrew John Cooke, Lene Teuber, Naheed Mirza, Frank Wätjen -
Publication number: 20100029621Abstract: The present invention relates to hexafluoroisopropanol derivatives having the general formula I to pharmaceutical compositions comprising the same and to the use of these hexafluoroisopropanol derivatives in the treatment of atherosclerosis.Type: ApplicationFiled: May 13, 2009Publication date: February 4, 2010Inventors: Andrew John Cooke, Andrew Stanley Edwards, Fiona Elizabeth Andrews, David Jonathan Bennett, Olaf Nimz, Emma Louise Carswell
-
Publication number: 20090264416Abstract: The present invention relates to N-benzyl,N?-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N?-arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.Type: ApplicationFiled: August 19, 2008Publication date: October 22, 2009Inventors: Koc-Kan Ho, Andrew Laird Roughton, Irina Neagu, Jui-Hsiang Chan, Nasrin Ansari, Michelle Lee Morris, Yajing Rong, Michael Ohlmeyer, Andrew John Cooke, Andrew Stanley Edwards, David Jonathan Bennett
-
Patent number: 6905136Abstract: The present invention relates to a collapsible support (1) for absorbing energy during an impact, particularly to a support for an automobile knee bolster (50). The collapsible support (1) has the form of a tubular body with closed ends. The body extends along a longitudinal axis (3) along which it will collapse during an impact. The support (1) has two opposing end walls (4,10) substantially perpendicular to the axis (3). The two end walls (4,10) are connected by four similar stepped side walls (8) of rectangular plan form that substantially enclose the longitudinal axis (3) such that the side and end walls (8,4,10) of the collapsible support (1) substantially enclose an internal volume. The tubular body is adapted to deform so that sections (31-35) of side walls 8 collapse with one section moving inside another adjacent section upon the application of a compressive force applied to said body along said axis 3.Type: GrantFiled: November 26, 2002Date of Patent: June 14, 2005Assignee: Visteon Global Technologies, Inc.Inventors: Paulo Vidal, Paul Pickett, Andrew John Cooke
-
Publication number: 20030184070Abstract: The present invention relates to a collapsible support (1) for absorbing energy during an impact, particularly to a support for an automobile knee bolster (50). The collapsible support (1) has the form of a tubular body with closed ends. The body extends along a longitudinal axis (3) along which it will collapse during an impact. The support (1) has two opposing end walls (4,10) substantially perpendicular to the axis (3). The two end walls (4,10) are connected by four similar stepped side walls (8) of rectangular plan form that substantially enclose the longitudinal axis (3) such that the side and end walls (8,4,10) of the collapsible support (1) substantially enclose an internal volume. The tubular body is adapted to deform so that sections (31-35) of side walls 8 collapse with one section moving inside another adjacent section upon the application of a compressive force applied to said body along said axis 3.Type: ApplicationFiled: November 26, 2002Publication date: October 2, 2003Applicant: Visteon Global Technologies, Inc.Inventors: Paulo Vidal, Paul Picket, Andrew John Cooke