Abstract: A centraliser (10) for use in centralising tubing (12) in a bore (W) comprises a first end collar (14), a second end collar (16) and a number of elongate strut members (18). The strut members (18) are interposed between the first end collar (14) and the second end collar (16) and are circumferentially arranged and spaced around the first end collar (14) and second end collar (16). The strut members (18) have angled wing portions (32). The centraliser (10) comprises a retaining arrangement (20) for holding the strut members (18), which comprises a retainer member (22) extending circumferentially between and disposed through the strut members (18). The centraliser (10) comprises a release arrangement (24) configured to release the retaining arrangement (20) and permit the strut members (18) to move between radially retracted and radially extended positions.

Abstract: Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.

Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.

Abstract: A method includes obtaining a series of more than two Boolean events, each respective Boolean event having either a first value indicating that reimbursement for a respective overpayment of a service was timely received or a second value indicating reimbursement was not timely received. The method includes determining an actual number of switch events in the series of Boolean events and determining an expected number of switch events. The method includes determining a confidence interval for the expected number of switch events, and determining a score based on the actual number of switch events, the expected number of switch events, and the confidence interval. The score is indicative of a fault in a process generating the series of Boolean events. The method includes generating an alert based on the score being greater than or equal to a threshold score.

Abstract: A centraliser (10) for use in centralising tubing (12) in a bore (W) comprises a first end collar (14), a second end collar (16) and a number of elongate strut members (18). The strut members (18) are interposed between the first end collar (14) and the second end collar (16) and are circumferentially arranged and spaced around the first end collar (14) and second end collar (16). The strut member (18) have a first end portion (20), a second end portion (22), an intermediate portion (24) and angled wing portions (26) which extend from the intermediate portion (24).

Abstract: A centraliser (10;110) for centralising tubing (T) in a bore (B) comprises a body (12;112), one or more blades (14;114) extending radially outwards from the body (12;112). One or more of the blades (14;114) receives a blade standoff (20;120) which is disposed on and extends radially outwards from the blade (14;114) with which it is associated. The blade standoff (20;120) is configured to space the blade (14;114) from the bore (B) and is configured to form a galvanic inhibitor between the blade (14;114) and the bore (B).

Abstract: The present disclosure relates to method and systems for amplifying nucleic acid molecule and quantify amplification thereof, with a polymerase chain reaction (PCR) or a loop-mediated isothermal amplification (LAMP), through bulk heating a biological enzymatic reaction mixture in solution containing nucleic acid templates, polymerase enzyme, and chemically modified nanoparticles. The method and system may comprise quantify amplification by irradiating the biological enzymatic reaction mixture during an annealing and/or elongation steps with an ultraviolet (UV) light source.

Abstract: A centraliser (10) for use in centralising tubing (12) in a bore (W) comprises a first end collar (14), a second end collar (16) and a number of elongate strut members (18). The strut members (18) are interposed between the first end collar (14) and the second end collar (16) and are circumferentially arranged and spaced around the first end collar (14) and second end collar (16). The strut member (18) have a first end portion (20), a second end portion (22), an intermediate portion (24) and angled wing portions (26) which extend from the intermediate portion (24).

Abstract: Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.

Abstract: Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.

Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.

Abstract: Methods and apparatus relate to the synthesis of polynucleotides having a predefined sequence on a support. Assembly methods include primer extension to generate overlapping construction oligonucleotides and assembly of the polynucleotides of interest onto an anchor support-bound oligonucleotides. Methods and apparatus for selection of polynucleotides having the predefined sequence and/or length are disclosed.

Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.

Abstract: A centraliser comprises two collars that are connected by asymmetric spring bows. The spring bows each comprise two arcs, where the curvature of one arc is inverted with respect to the curvature of the other arc, one being concave and the other convex. The spring bows are in sets that are equidistantly spaced around the circumference of the collars, each set having the same configuration, and the opposite configuration to the spring bows in the other set. Upon insertion into a wellbore, one set of spring bows is therefore compressed before the other set. Upon compression, the deformation of the concave arc leads to mutual deformation of the convex arc, and the spring bows adopt a flatter configuration, enhancing the rotational freedom of the tubular.

Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.

Abstract: A centralizer comprises two collars that are connected by asymmetric spring bows. The spring bows each comprise two arcs, where the curvature of one arc is inverted with respect to the curvature of the other arc, one being concave and the other convex. The spring bows are in sets that are equidistantly spaced around the circumference of the collars, each set having the same configuration, and the opposite configuration to the spring bows in the other set. Upon insertion into a wellbore, one set of spring bows is therefore compressed before the other set. Upon compression, the deformation of the concave arc leads to mutual deformation of the convex arc, and the spring bows adopt a flatter configuration, enhancing the rotational freedom of the tubular.

Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.

Abstract: A vehicle airflow control apparatus (900) has an air inlet (902) at the rear quarter glass (906) of the vehicle and ducting (908) leading via an openable joint (912) and rear ducting (912) past a bend (916) to an exit blowing aperture (918), a concertina element (928) allowing duct movement, the openable joint having a self-alignment cup (938) with wedging inner sides (944, 946), an interface seal connecting the rear ducting and the cup, a deployable spoiler (920) having a drive system (978), 10 outboard positional control of the spoiler being provided by a rod (998) with cone surfaces (1000, 1002).

Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.