Patents by Inventor Andrew L. Salzman
Andrew L. Salzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8609833Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.Type: GrantFiled: April 20, 2012Date of Patent: December 17, 2013Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman
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Publication number: 20120264706Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.Type: ApplicationFiled: April 20, 2012Publication date: October 18, 2012Applicant: INOTEK PHARMACEUTICALS CORPORATIONInventors: Prakash JAGTAP, Csaba SZABO, Andrew L. SALZMAN
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Patent number: 8263078Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.Type: GrantFiled: September 5, 2008Date of Patent: September 11, 2012Assignees: Inotek Pharmaceuticals Corporation, Yeda Research and Development Co., Ltd.Inventors: Nurit Rachamim, Andrew L. Salzman, Kanneganti Murthy
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Patent number: 8183224Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.Type: GrantFiled: August 4, 2008Date of Patent: May 22, 2012Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman
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Patent number: 8173130Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.Type: GrantFiled: September 5, 2008Date of Patent: May 8, 2012Assignee: Inotek Pharmaceuticals CorporationInventors: Andrew L. Salzman, Kanneganti Murthy
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Patent number: 8133880Abstract: The invention relates to Purine Derivatives having the formula; The invention also relates to pharmaceutical compositions comprising an effective amount of the Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of the Purine Derivative to a subject in need thereof.Type: GrantFiled: November 12, 2010Date of Patent: March 13, 2012Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Andrew L. Salzman, Csaba Szabo
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Publication number: 20110059915Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of a Purine Derivative to a subject in need thereof.Type: ApplicationFiled: November 12, 2010Publication date: March 10, 2011Applicant: INOTEK PHARMACEUTICALS CORPORATIONInventors: Prakash JAGTAP, Andrew L. SALZMAN, Csaba SZABO
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Patent number: 7863253Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of a Purine Derivative to a subject in need thereof.Type: GrantFiled: September 19, 2005Date of Patent: January 4, 2011Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Andrew L. Salzman, Csaba Szabo
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Publication number: 20100239583Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating infections and diseases using anti-flagellin antibodies in humans, other animals and birds.Type: ApplicationFiled: March 4, 2010Publication date: September 23, 2010Applicant: INOTEK PHARMACEUTICALS CORPORATIONInventors: Kanneganti MURTHY, Andrew L. SALZMAN
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Patent number: 7732424Abstract: The present invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's core body temperature, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ophthalmic condition, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.Type: GrantFiled: November 30, 2006Date of Patent: June 8, 2010Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Andrew L. Salzman
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Publication number: 20090208506Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.Type: ApplicationFiled: September 5, 2008Publication date: August 20, 2009Applicants: Inotek Pharmaceuticals Corporation, Yeda Research and Development Co., Ltd.Inventors: Nurit Rachamim, Andrew L. Salzman, Kanneganti Murthy
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Publication number: 20090191208Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.Type: ApplicationFiled: September 5, 2008Publication date: July 30, 2009Applicant: Inotek Pharmaceuticals CorporationInventors: Andrew L. Salzman, Kanneganti Murthy
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Publication number: 20090062314Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.Type: ApplicationFiled: August 4, 2008Publication date: March 5, 2009Applicant: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman
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Publication number: 20080262016Abstract: The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.Type: ApplicationFiled: June 16, 2008Publication date: October 23, 2008Applicant: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Erkan Baloglu, John H. van Duzer, Csaba Szabo, Andrew L. Salzman, Aloka Roy, William Williams, Alexander Nivorozhkin
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Patent number: 7423144Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.Type: GrantFiled: May 25, 2005Date of Patent: September 9, 2008Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman
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Patent number: 7268143Abstract: The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.Type: GrantFiled: October 12, 2004Date of Patent: September 11, 2007Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman, Aloka Roy, William Williams
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Patent number: 6958324Abstract: Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in need thereof are disclosed.Type: GrantFiled: March 26, 2002Date of Patent: October 25, 2005Assignee: Inotek Pharmaceuticals CorporationInventors: Andrew L. Salzman, Csaba Szabo
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Patent number: 6956035Abstract: The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.Type: GrantFiled: February 28, 2003Date of Patent: October 18, 2005Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Erkan Baloglu, John H. van Duzer, Csaba Szabo, Andrew L. Salzman
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Patent number: 6828319Abstract: The invention provides novel classes of substituted Indeno[1,2-c]isoquinoline Compounds. Pharmaceutical compositions and methods of making and using the compounds, are also described.Type: GrantFiled: August 30, 2002Date of Patent: December 7, 2004Assignee: Inotek Pharmaceuticals CorporationInventors: Prakash Jagtap, Erkan Baloglu, John H. van Duzer, Csaba Szabo, Andrew L. Salzman
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Publication number: 20040039009Abstract: The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.Type: ApplicationFiled: February 28, 2003Publication date: February 26, 2004Inventors: Prakash Jagtap, Erkan Baloglu, John H. van Duzer, Csaba Szabo, Andrew L. Salzman, Aloka Roy, William Williams, Alexander Nivoroshkin