Patents by Inventor Andrew Lane
Andrew Lane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240074829Abstract: Tissue access devices and methods of using the same are disclosed. The devices can have a sensor configured to occlude a flow path by deflecting a membrane into the flow path when the devices become dislodged from tissue. The sensor can be configured to partially or fully occlude the flow path. The sensor can have a spring. The spring can be biased to move the sensor from a sensor first configuration to a sensor second configuration when a force applied by the sensor first surface against a non-sensor surface changes from a first force to a second force less than the first force. The membrane can be deflected into the flow path when the sensor is in the sensor second configuration.Type: ApplicationFiled: November 9, 2023Publication date: March 7, 2024Applicant: Hemotek Medical IncorporatedInventors: Patrick ROUSCHE, Peter TEK, Charles VENTURA, Richard A. SCRIBNER, Andrew BLACK, Andrew LEOPOLD, Mark CARLSON, Todd MACY, Daniel LANE, Adam HENSEL, Edward BROWKA
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Publication number: 20230307088Abstract: Controlling antibody affinity and expression are key to clinical applications. High affinity antibodies correlate with higher specificity and can be used at lower doses. Presently, antibody maturation is tackled with directed evolution methods. In this case, an initial library of mutated binders is seeded into a process and affinity is improved through multiple rounds of mutation and selection. However, the present disclosure employs a machine learning approach to computationally mature antibody sequences using a process having parallels to directed evolution. These antibody sequences can be manufactured into physical antibodies after their computation and verification. Additionally, the present method has the potential to outperform directed evolution when targeting a specific affinity, and is applicable to general protein-protein interactions.Type: ApplicationFiled: July 28, 2021Publication date: September 28, 2023Inventors: Zachary Kohl Costello, Jacob Feala, Andrew Lane Beam
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Patent number: 11674950Abstract: The present invention is based in part on the identification of DPH1 and other members of the diphthamide synthesis pathway as biomarkers of resistance to an ADP-ribosylating toxin in a cell, and methods for identification, assessment, and treatment of a condition that is resistant to an ADP-ribosylating toxin.Type: GrantFiled: October 30, 2018Date of Patent: June 13, 2023Assignees: Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.Inventors: Andrew Lane, Jon Aster
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Publication number: 20230122168Abstract: Accurate function estimations and well-calibrated uncertainties are important for Bayesian optimization (BO). Most theoretical guarantees for BO are established for methods that model the objective function with a surrogate drawn from a Gaussian process (GP) prior. GP priors are poorly-suited for discrete, high-dimensional, combinatorial spaces, such as biopolymer sequences. Using a neural network (NN) as the surrogate function can obtain more accurate function estimates. Using a NN can allow arbitrarily complex models, removing the GP prior assumption, and enable easy pretraining, which is beneficial in the low-data BO regime. However, a fully-Bayesian treatment of uncertainty in NNs remains intractable, and existing approximate methods, like Monte Carlo dropout and variational inference, can highly miscalibrate uncertainty estimates.Type: ApplicationFiled: January 29, 2021Publication date: April 20, 2023Inventors: Molly Krisann Gibson, Kevin Kaichuang Yang, Maxim Baranov, Andrew Lane Beam
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Publication number: 20220270711Abstract: Systems, apparatuses, software, and methods for engineering amino acid sequences configured to have specific protein functions or properties. Machine learning is implemented by methods to process an input seed sequence and generate as output an optimized sequence having the desired function or property.Type: ApplicationFiled: July 31, 2020Publication date: August 25, 2022Inventors: Jacob D. Feala, Andrew Lane Beam, Molly Krisann Gibson, Bernard Joseph Cabral
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Publication number: 20220122692Abstract: Systems, apparatuses, software, and methods for identifying associations between amino acid sequences and protein functions or properties. The application of machine learning is used to generate models that identify such associations based on input data such as amino acid sequence information. Various techniques including transfer learning can be utilized to enhance the accuracy of the associations.Type: ApplicationFiled: February 10, 2020Publication date: April 21, 2022Inventors: Jacob D. Feala, Andrew Lane Beam, Molly Krisann Gibson
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Publication number: 20210325368Abstract: The present invention is based in part on the identification of DPH1 and other members of the diphthamide synthesis pathway as biomarkers of resistance to an ADP-ribosylating toxin in a cell, and methods for identification, assessment, and treatment of a condition that is resistant to an ADP-ribosylating toxin.Type: ApplicationFiled: October 30, 2018Publication date: October 21, 2021Inventors: Andrew Lane, Jon Aster
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Publication number: 20210325916Abstract: In some embodiments, a tube portion can be configured to be fluidically coupled to a patient access component. A source of pressurized fluid can be coupled to the tube portion and can be configured to deliver fluid to the tube portion at a source pressure. A fluid pressure regulating device can include an expandable reservoir and can be coupled to the tube portion such that the expandable reservoir is in fluidic communication with the tube portion. The fluid pressure regulating device can be configured such that, when fluid is delivered from the source of pressurized fluid to the lumen of the tube portion at the source pressure, the expandable reservoir of the fluid pressure regulating device can receive fluid such that the expandable reservoir of the fluid pressure regulating device expands and fluid is delivered from the lumen of the tube portion to the patient via the patient access component.Type: ApplicationFiled: December 21, 2020Publication date: October 21, 2021Inventors: Andrew LANE, Savannah CARLSEN, Galen C. ROBERTSON, Mark D. PIEHL, Stephen LATHAM, Douglas RODENKIRCH, Jesse DARLEY, Curtis IRWIN, Amrish CHOURASIA
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Patent number: 10871788Abstract: In some embodiments, a tube portion can be configured to be fluidically coupled to a patient access component. A source of pressurized fluid can be coupled to the tube portion and can be configured to deliver fluid to the tube portion at a source pressure. A fluid pressure regulating device can include an expandable reservoir and can be coupled to the tube portion such that the expandable reservoir is in fluidic communication with the tube portion. The fluid pressure regulating device can be configured such that, when fluid is delivered from the source of pressurized fluid to the lumen of the tube portion at the source pressure, the expandable reservoir of the fluid pressure regulating device can receive fluid such that the expandable reservoir of the fluid pressure regulating device expands and fluid is delivered from the lumen of the tube portion to the patient via the patient access component.Type: GrantFiled: August 13, 2019Date of Patent: December 22, 2020Assignee: 410 Medical, Inc.Inventors: Andrew Lane, Savannah Carlsen, Galen C. Robertson, Mark D. Piehl
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Publication number: 20200050222Abstract: In some embodiments, a tube portion can be configured to be fluidically coupled to a patient access component. A source of pressurized fluid can be coupled to the tube portion and can be configured to deliver fluid to the tube portion at a source pressure. A fluid pressure regulating device can include an expandable reservoir and can be coupled to the tube portion such that the expandable reservoir is in fluidic communication with the tube portion. The fluid pressure regulating device can be configured such that, when fluid is delivered from the source of pressurized fluid to the lumen of the tube portion at the source pressure, the expandable reservoir of the fluid pressure regulating device can receive fluid such that the expandable reservoir of the fluid pressure regulating device expands and fluid is delivered from the lumen of the tube portion to the patient via the patient access component.Type: ApplicationFiled: August 13, 2019Publication date: February 13, 2020Inventors: Andrew LANE, Savannah CARLSEN, Galen C. ROBERTSON, Mark D. PIEHL, Stephen LATHAM, Douglas RODENKIRCH, Jesse DARLEY, Curtis IRWIN, Amrish CHOURASIA
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Patent number: 9486771Abstract: A method and apparatus for producing a carbon monoxide containing product in which cathode and anode sides of an electrically driven oxygen separation device are contacted with carbon dioxide and a reducing agent, respectively. The carbon dioxide is reduced to carbon monoxide through ionization of oxygen and the reducing agent lowers the partial pressure of oxygen at the anode side to partially drive oxygen ion transport within the device through the consumption of the oxygen and to supply heat. The lowering of oxygen partial pressure reduces voltage and therefore, electrical power required to be applied to the device and the heat is supplied to heat the device to an operational temperature and to the reduction of the carbon dioxide occurring at the cathode side. The device can be used as part of an integrated apparatus in which the carbon dioxide is supplied from a waste stream of a process plant.Type: GrantFiled: October 14, 2013Date of Patent: November 8, 2016Assignee: PRAXAIR TECHNOLOGY, INC.Inventors: Jonathan Andrew Lane, Gervase Maxwell Christie, Dante Patrick Bonaquist
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SURGICAL INSTRUMENTS, SYSTEMS, AND METHODS FOR COUPLING OF ELECTRICAL ENERGY TO SURGICAL INSTRUMENTS
Publication number: 20160271385Abstract: A systems and method for coupling electrical energy to the medical instruments includes a tubular socket having a conductive region and a lumen for receiving a segment of a medical instrument. An energy source is electrically coupled to a conductor in contact with an outer surface of the tubular socket, such that the conductor and the conductive portion of the tubular socket conduct energy to the instrument. The segment of the medical is instrument is rotationally engageable with the tubular socket such that axially rolling of the tubular socket causes axial rolling of a portion of the instrument shaft.Type: ApplicationFiled: July 11, 2014Publication date: September 22, 2016Inventors: Patrick Sterlina, Galen C. Robertson, Nicholas J. Jardine, Andrew Lane, Lucas Tew -
Publication number: 20160194718Abstract: The present invention relates to methods for identifying, assessing, preventing, and treating cancer (e.g., lymphoid and/or myeloid malignancies such as B-ALL in humans). A variety of histone H3K27rne3 biomarkers are provided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or activity of one or more of the biomarkers is associated with cancer status and indicates amenability to treatment or prevention by modulating H3K27me3 levels. The present invention further relates to methods of increasing the number of lymphoid progenitor cells (e.g., increase self-renewal and cell proliferation) by contacting the lymphoid progenitor cells (e.g., wild type and/or genomically altered cells) with an agent that inhibits polycomb repressor complex 2 (PRC2) activity or reduces H3K27roe3 levels.Type: ApplicationFiled: May 21, 2014Publication date: July 7, 2016Inventors: Andrew Lane, David Weinstock
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Publication number: 20140044604Abstract: A method and apparatus for producing a carbon monoxide containing product in which cathode and anode sides of an electrically driven oxygen separation device are contacted with carbon dioxide and a reducing agent, respectively. The carbon dioxide is reduced to carbon monoxide through ionization of oxygen and the reducing agent lowers the partial pressure of oxygen at the anode side to partially drive oxygen ion transport within the device through the consumption of the oxygen and to supply heat. The lowering of oxygen partial pressure reduces voltage and therefore, electrical power required to be applied to the device and the heat is supplied to heat the device to an operational temperature and to the reduction of the carbon dioxide occurring at the cathode side. The device can be used as part of an integrated apparatus in which the carbon dioxide is supplied from a waste stream of a process plant.Type: ApplicationFiled: October 14, 2013Publication date: February 13, 2014Inventors: Jonathan Andrew Lane, Gervase Maxwell Christie, Dante Patrick Bonaquist
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Patent number: 8591718Abstract: A method and apparatus for producing a carbon monoxide containing product in which cathode and anode sides of an electrically driven oxygen separation device are contacted with carbon dioxide and a reducing agent, respectively. The carbon dioxide is reduced to carbon monoxide through ionization of oxygen and the reducing agent lowers the partial pressure of oxygen at the anode side to partially drive oxygen ion transport within the device through the consumption of the oxygen and to supply heat. The lowering of oxygen partial pressure reduces voltage and therefore, electrical power required to be applied to the device and the heat is supplied to heat the device to an operational temperature and to the reduction of the carbon dioxide occurring at the cathode side. The device can be used as part of an integrated apparatus in which the carbon dioxide is supplied from a waste stream of a process plant.Type: GrantFiled: December 7, 2010Date of Patent: November 26, 2013Assignee: Praxair Technology, Inc.Inventors: Jonathan Andrew Lane, Gervase Maxwell Christie, Dante Patrick Bonaquist
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Patent number: 8511139Abstract: A testing system having a retainer configured to selectively retain a specimen and a carrier configured to selectively carry the retainer along an at least partially predefined space curve from a first point along the space curve to a second point along the space curve, wherein a gravitational potential energy of the retainer at the first point is greater than a gravitational potential energy of the retainer at the second point. The retainer is configured to release the specimen in response to the retainer moving to a location that provides the retainer a predetermined gravitational potential energy.Type: GrantFiled: February 28, 2011Date of Patent: August 20, 2013Assignee: Research In Motion LimitedInventors: Christopher Andrew Lane, Cornel Mercea
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Publication number: 20120216596Abstract: A testing system having a retainer configured to selectively retain a specimen and a carrier configured to selectively carry the retainer along an at least partially predefined space curve from a first point along the space curve to a second point along the space curve, wherein a gravitational potential energy of the retainer at the first point is greater than a gravitational potential energy of the retainer at the second point. The retainer is configured to release the specimen in response to the retainer moving to a location that provides the retainer a predetermined gravitational potential energy.Type: ApplicationFiled: February 28, 2011Publication date: August 30, 2012Applicant: RESEARCH IN MOTION LIMITEDInventors: Christopher Andrew Lane, Cornel Mercea
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Publication number: 20120142305Abstract: There are disclosed methods that enable a user in an emergency situation to capture an image (such as a picture image or a video image) and transmit the image to an emergency authority (such as a PSAP) and/or to another party. In some embodiments, these operations can be performed while the user equipment and/or a Universal Integrated Circuit Card (UICC) inserted into the user equipment are in a locked condition. Devices and systems are also disclosed for performing the methods, as well as a computer-readable medium having instructions stored thereon that, when executed, perform the methods.Type: ApplicationFiled: December 7, 2010Publication date: June 7, 2012Applicant: RESEARCH IN MOTION LIMITEDInventors: CHRISTOPHER ANDREW LANE, CORNEL MERCEA
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Publication number: 20110253551Abstract: A method and apparatus for producing a carbon monoxide containing product in which cathode and anode sides of an electrically driven oxygen separation device are contacted with carbon dioxide and a reducing agent, respectively. The carbon dioxide is reduced to carbon monoxide through ionization of oxygen and the reducing agent lowers the partial pressure of oxygen at the anode side to partially drive oxygen ion transport within the device through the consumption of the oxygen and to supply heat. The lowering of oxygen partial pressure reduces voltage and therefore, electrical power required to be applied to the device and the heat is supplied to heat the device to an operational temperature and to the reduction of the carbon dioxide occurring at the cathode side. The device can be used as part of an integrated apparatus in which the carbon dioxide is supplied from a waste stream of a process plant.Type: ApplicationFiled: December 7, 2010Publication date: October 20, 2011Inventors: Jonathan Andrew Lane, Gervase Maxwell Christie, Dante Patrick Bonaquist
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Patent number: 7883571Abstract: Purification method and apparatus for purifying a gas stream by oxygen removal. The apparatus includes primary and secondary oxygen separation zones and tubular electrically driven oxygen separation elements. There are more elements in the primary zone than the secondary zone so that low concentrations of oxygen can be obtained in a purified stream and turbulent flow conditions can also be obtained that will permit purification to very low levels. In addition, a junction is provided to connect the tubular separation elements to metallic elements such as manifolds.Type: GrantFiled: October 8, 2010Date of Patent: February 8, 2011Assignee: Praxair Technology, Inc.Inventors: Jonathan Andrew Lane, David M. Reed