Abstract: An ultrasonic transducer probe comprises an array transducer and a microbeamformer ASIC (46a, 46b) containing transmit amplifiers and receive circuitry for operation of the array transducer. For higher power operation, the drive current of the amplifiers is increased, rather than the transmit voltage. The elements of the array present a low impedance to the transmit amplifiers for increased drive current by their construction of thin layers (12) of piezoelectric material which are electrically coupled in parallel to an amplifier while being mechanically coupled in series for ultrasound transmission.

Abstract: Methods and compositions for the treatment of a corneal dystrophy in a subject in need thereof are provided. In one aspect, the method includes the step of obtaining a plurality of stem cells comprising a nucleic acid mutation in a corneal dystrophy target nucleic acid from the subject and manipulating the nucleic acid mutation in one or more stem cells of the plurality of stem cells to correct the nucleic acid mutation, thereby forming one or more manipulated stem cells. The manipulated stem cells are isolated and then transplanted into the subject. In some embodiments, the nucleic acid mutation is manipulated using CRISPR system.

Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.

Abstract: A novel maize variety designated X13R056 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X13R056 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X13R056 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X13R056, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X13R056 are provided. Methods for producing maize varieties derived from maize variety X13R056 and methods of using maize variety X13R056 are disclosed.

Abstract: Disclosed herein are system, method and/or device embodiments for using a wireless mouthguard with pressure sensors for measuring bite compression forces generated by a bruxism patient during sleep. A system comprises a mouthguard and a microelectromechanical system (MEMS) coupled to a portion of the mouthguard covering an axial plane of a tooth. The MEMS comprises an antenna, a capacitive sensor, a microcontroller, and a power supply. The sensor generates sensor signals corresponding to a force generated by a mouthguard wearer's bite. The MEMS may then transmit data describing the wearer's bite force over a period of time to an external computing device for display and analysis.

Abstract: The present disclosure relates to compounds that bind to human GITR, pharmaceutical compositions comprising such compounds, and methods of using such compounds.

Abstract: Methods of welding high manganese steel, the methods comprising: supplying at least one piece of high manganese steel; supplying the metal cored wire comprising a steel sheath with a core comprising powders of certain metal and carbon percentages and at least one of: i: sulfur in an amount less than 0.3 wt. %; or ii. phosphorous in an amount less than 0.03 wt. %; or a combination thereof; and the balance with iron; submerging the at least one piece of high manganese steel in a slag and arc stabilizer; and applying a current to the metal cored wire to produce a liquid alloy steel composition on the at least one piece of high manganese steel.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer-readable media that generates editable email components by utilizing an Answer Set Programming (ASP) model with hard and soft constraints. For instance, in one or more embodiments, the disclosed systems generate editable email components from email fragments of an email file utilizing an Answer Set Programming (ASP) model. In particular, the disclosed systems extract facts for the ASP model from the email file. In addition, the disclosed systems determine rows or columns defining cells of the email file utilizing ASP hard constraints defined by a first set of ASP atoms corresponding to the facts. Moreover, the disclosed systems determine editable email component classes for the email fragments utilizing ASP soft constraints defined by ASP classification weights and a second set of ASP atoms corresponding to the facts.

Abstract: Systems, methods, and control systems for a switching rocker arm assembly are disclosed. A switching rocker arm (10) engages a valve (29), the switching rocker arm (10) is movable by contact with a cam (60) having a lift portion (59) and a base circle (58). The switching rocker arm (10) comprises an inner arm (20), an outer arm (12) pivotably secured to the inner arm (20) and having a latch bore, and a latch pin (28) selectively movable between a first position where the latch pin (28) does not contact the inner arm (20), and a second position wherein the latch pin (28) contacts the inner arm (20). A solenoid assembly (500) is energized while the rocker arm is in contact with the lift portion (59) of the cam. The solenoid assembly is direct-acting and overhead and is calibratable with respect to the rocker arm.

Abstract: Various methods, apparatuses/systems, and media for implementing automatic project transformation and migration processes are disclosed. A processor accesses a private cloud to fetch data related to a state of a project and posts migration mapping data to a migration director corresponding to the project based on the fetched data. The processor also sets user interface state according to project migration state; queues the project for processing; transforms the project to a standardized line of business (LOB) configuration; determines that a validation environment is in a clean configuration; migrates, based on determining that the validation environment is in a clean configuration, the transformed project to the validation environment; and receives user input to approve the migrated project.

Abstract: A protective housing structure for a heating, ventilation, and air conditioning (HVAC) system comprises a first end and a second end with a centerline extending there between. The protecting housing structure includes a cover section that is located between the first end and second end. The cover section comprises a dome-shaped top panel that is rigidly attached to a first sidewall and a second sidewall.

Abstract: Methods of forming semiconductor packages include providing a lead frame having leads and no tie-bars. Tape is attached to the lead frame and one or more semiconductor die are coupled therewith. Electrical contacts of the die are interconnected with the leads using electrical connectors. An encapsulated assembly is formed by at least partially encapsulating the die and electrical connectors. The assembly is singulated to form a semiconductor package. The tape is detached from the package or encapsulated assembly. One or more die attach flags may be attached to the tape and the die may be attached thereto. Semiconductor packages formed using the methods include one or more semiconductor die at least partially encapsulated, pins exposed through the encapsulant, electrical connectors within the encapsulant and electrically interconnecting the pins with electrical contacts of the die, and no tie-bars coupling the die with the pins. Packages may also include die attach flags.

Abstract: Methods and systems for resilient network communication are provided. In one aspect, a network includes multiple edge network elements, core network elements, and off-network network elements. Each network element has multiple ports. Communication paths exist between edge network elements, traversing core network elements. A maintenance domain maintains communication resiliency in the network through maintenance domain entities that detect network communication faults. Maintenance domain entities are associated with ports of edge network elements. Proxy maintenance domain entities, associated with unused ports of core network elements or edge network elements allow for network extensibility as additional network elements may be provisioned in the network over time.

Abstract: Technology described herein can verify readiness of a customer tenant/customer for cloud provisioning based on the customer tenant. An example method comprises collecting, by a system comprising a processor, data based on user input from a customer tenant via a user interface, the data comprising information of a configuration setting that is to be used for cloud provisioning of a device based on the configuration setting. The method comprises, in response to collecting the configuration setting, analyzing, by the system, the configuration setting by comparing the configuration setting with respect to a selected rules check. The method comprises, in response to the analyzing of the configuration setting, determining, by the system, whether the configuration setting is acceptable for use in the cloud provisioning based on the configuration setting.

Abstract: According to certain embodiments, a device comprises a body, a mechanical propulsion system affixed to the body to cause the body to traverse a multi-oriented surface and to prevent contact between the body and the multi-oriented surface, a thrust system to apply a thrust force to the device that opposes a gravitational force acting on the device, and a payload with at least one sensor to detect a characteristics of the multi-oriented surface.

Abstract: A self-leveling sensor assembly comprising an outer bushing defining a bushing passage, a bushing axis extending centrally through the bushing passage; an inner housing received in the bushing passage and rotatable about the bushing axis, the inner housing comprising a housing weight disposed at a first housing side of the inner housing; and a vibration sensor mounted to the inner housing and defining a sensor axis; wherein the housing weight is configured to pull the first housing side of the inner housing downward to rotate the inner housing and the vibration sensor about the bushing axis and to align the sensor axis is a desired orientation.

Abstract: Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.

Abstract: A gastric bypass device includes an occlusion device that is adapted to be deployed relative to a patient's pyloric sphincter, an anastomosis anchor that is adapted to be deployed relative to an anastomosis between the patient's stomach and their small intestine, and a tether that extends through the patient's small intestine between the occlusion device and the anastomosis anchor. A dynamic leash may be secured relative to the occlusion device and may work in conjunction with the tether to help hold the occlusion device in place. The gastric bypass device may be deployed using a variety of methods including a push-pull wire method, a rail method, a garage method, a two-piece method and a comprehensive method.

Abstract: The present disclosure describes devices and methods for improving the power efficiency and control of an induction heating system. In particular, the induction heating system includes a series resonant bridge inverter circuit and a control circuit. The inverter circuit includes one or more induction coils that are structured to inductively couple to the cookware to heat the cookware and a current sensor structured to sense a coil current signal across the one or more inductor coils. In particular, the current sensor is structured to generate a positive sensed voltage signal corresponding to a positive portion of the coil current signal and a negative sensed voltage signal corresponding to a negative portion of the coil current. The control signal is structured to control switching of a first and a second set of switches based on the positive and negative sensed voltage signals.