Abstract: A flexible electrode array with hundreds or thousands channels for clinical use includes an array of at least hundreds of electrodes on a flexible biocompatible polymer substrate. Perfusion through holes are provided through the substrate. Individual elongate leads connect to each of the electrodes, the elongate lead connections being supported by the flexible biocompatible polymer substrate and extending away from the array. Flexible biocompatible polymer insulates the individual elongate lead connections and supporting the array. An interposer with individual channel connections is conductively bonded to the individual elongate lead connections. Sterile bag packaging encloses a portion of the interposer, where the outer side of the package including the array and individual elongate lead is sterile while the inner side of the packaging is non-sterile. The portion interposer inside the package is configured to connect to a circuit board within the packaging.

Abstract: A computer-implemented system for training a subject to improve psychophysiological function for performance of stress-inducing activity includes a sensor interface device and a non-transitory, tangible computer readable storage medium storing computer program code. The sensor interface provides measurement of a physiological parameter of the subject, indicating stress in the subject. The computer readable storage medium stores computer code that provides a set of training segments presenting the subject with one or more visual, audible, or tactile prompts wherein at least one of the training segments simultaneously presents the subject with a stress-inducing prompt while inducing the subject to perform a relaxation-inducing protocol.

Abstract: A computer-implemented system for training a subject to improve psychophysiological function for performance of stress-inducing activity includes a sensor interface device and a non-transitory, tangible computer readable storage medium storing computer program code. The sensor interface provides measurement of a physiological parameter of the subject, indicating stress in the subject. The computer readable storage medium stores computer code that provides a set of training segments presenting the subject with one or more visual, audible, or tactile prompts wherein at least one of the training segments simultaneously presents the subject with a stress-inducing prompt while inducing the subject to perform a relaxation-inducing protocol.

Abstract: A method of improving psychophysiological function of a subject performing a stress-inducing activity using a computer includes, after a plurality of sensors that monitor stress-indicating physiological parameters have been coupled to the subject and to the computer, providing, by the computer to the subject, a set of training segments that each present the subject with one or more visual, audible, or tactile prompts, wherein in at least one of the training segments, the prompts induce the subject to simultaneously perform both the stress-inducing activity and a relaxation-inducing protocol. The computer provides the set of training segments until a value of at least one physiological parameter that indicates stress in the subject is within a pre-defined range of a baseline value of the parameter, thereby indicating that the subject has successfully performed the stress-inducing activity while maintaining alertness with a relative minimum of stress.

Abstract: A method of improving psychophysiological function of a subject performing a stress-inducing activity using a computer includes, after a plurality of sensors that monitor stress-indicating physiological parameters have been coupled to the subject and to the computer, providing, by the computer to the subject, a set of training segments that each present the subject with one or more visual, audible, or tactile prompts, wherein in at least one of the training segments, the prompts induce the subject to simultaneously perform both the stress-inducing activity and a relaxation-inducing protocol. The computer provides the set of training segments until a value of at least one physiological parameter that indicates stress in the subject is within a pre-defined range of a baseline value of the parameter, thereby indicating that the subject has successfully performed the stress-inducing activity while maintaining alertness with a relative minimum of stress.

Abstract: A method of improving psychophysiological function of a subject performing a stress-inducing activity using a computer includes, after a plurality of sensors that monitor stress-indicating physiological parameters have been coupled to the subject and to the computer, providing, by the computer to the subject, a set of training segments that each present the subject with one or more visual, audible, or tactile prompts, wherein in at least one of the training segments, the prompts induce the subject to simultaneously perform both the stress-inducing activity and a relaxation-inducing protocol. The computer provides the set of training segments until a value of at least one physiological parameter that indicates stress in the subject is within a pre-defined range of a baseline value of the parameter, thereby indicating that the subject has successfully performed the stress-inducing activity while maintaining alertness with a relative minimum of stress.

Abstract: A method of improving psychophysiological function of a subject performing a stress-inducing activity using a computer includes, after a plurality of sensors that monitor stress-indicating physiological parameters have been coupled to the subject and to the computer, providing, by the computer to the subject, a set of training segments that each present the subject with one or more visual, audible, or tactile prompts, wherein in at least one of the training segments, the prompts induce the subject to simultaneously perform both the stress-inducing activity and a relaxation-inducing protocol. The computer provides the set of training segments until a value of at least one physiological parameter that indicates stress in the subject is within a pre-defined range of a baseline value of the parameter, thereby indicating that the subject has successfully performed the stress-inducing activity while maintaining alertness with a relative minimum of stress.

Abstract: A computer-implemented method for improving psychophysiological function for performance of a subject under stress includes, after a plurality of sensors that monitor stress-indicating physiological parameters have been coupled to the subject, exposing the subject, using computer processes, to at least one training segment during which is determined a degree to which the subject has achieved a targeted level of least one stress-indicating physiological parameter as to be indicative of coherence in the subject. Additionally, the method includes providing, to the subject, feedback indicative of the degree to which the subject has achieved the targeted level of the at least one parameter as to be indicative of coherence in the subject.

Abstract: A computer-implemented method for improving psychophysiological function for performance of a subject under stress includes, after a plurality of sensors that monitor stress-indicating physiological parameters have been coupled to the subject, exposing the subject, using computer processes, to at least one training segment during which is determined a degree to which the subject has achieved a targeted level of least one stress-indicating physiological parameter as to be indicative of coherence in the subject. Additionally, the method includes providing, to the subject, feedback indicative of the degree to which the subject has achieved the targeted level of the at least one parameter as to be indicative of coherence in the subject.

Abstract: A computer-implemented method for improving psychophysiological function for performance of a subject under stress includes, after a plurality of sensors that monitor stress-indicating physiological parameters have been coupled to the subject, exposing the subject, using computer processes, to at least one training segment during which is determined a degree to which the subject has achieved a targeted level of least one stress-indicating physiological parameter as to be indicative of coherence in the subject. Additionally, the method includes providing, to the subject, feedback indicative of the degree to which the subject has achieved the targeted level of the at least one parameter as to be indicative of coherence in the subject.