Patents by Inventor Andrew M. Glenn
Andrew M. Glenn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240165215Abstract: The present disclosure relates to immunogenic compositions comprising at least one Yersinia pestis (Y. pestis) antigen, an aluminum salt adjuvant, and an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against Y. pestis in a subject in need thereof. The present disclosure also relates to kits and methods using the immunogenic compositions, or two separate compositions which together comprise the antigen, the aluminum salt adjuvant, and the oligonucleotide.Type: ApplicationFiled: June 29, 2023Publication date: May 23, 2024Applicants: Dynavax Technologies Corporation, The Government of the United States, as Represented by the Secretary of the ArmyInventors: Robert S. JANSSEN, David Novack, Wai Kwan Chung, Andrew M. Glenn, Lucy A. Ward
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Publication number: 20210317364Abstract: A scintillator material includes a polymer matrix, a primary dye in the polymer matrix, the primary dye being a fluorescent dye; a secondary dye, and a Li-containing compound in the polymer matrix, where the Li-containing compound is a Li salt of a short-chain aliphatic acid. In addition, the scintillator material exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons.Type: ApplicationFiled: April 8, 2021Publication date: October 14, 2021Inventors: Natalia P. Zaitseva, M Leslie Carman, Andrew M. Glenn, Andrew Neil Mabe
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Publication number: 20200224087Abstract: Scintillating plastics resistant to crazing and fogging, methods of making and using the same are disclosed. The scintillating plastics include: one or more primary polymers present in an amount ranging from about 40 wt % to about 95 wt %; one or more secondary polymers present in an amount ranging from about 1 wt % to about 60 wt %; and one or more fluors present in an amount ranging from about 0.1 wt % to about 50 wt %. Methods of making such plastics include: creating a homogenous mixture of precursor materials including primary polymer, secondary polymer, and fluor in the amounts set forth above; and polymerizing the homogenous mixture. Methods of using such plastics include: exposing the scintillating plastic to one or more extreme environmental conditions for a predetermined amount of time without generating crazing or fogging within the scintillating plastic. Various additional features and specific embodiments of these inventive concepts are also disclosed.Type: ApplicationFiled: March 20, 2020Publication date: July 16, 2020Inventors: Natalia P. Zaitseva, M Leslie Carman, Andrew M. Glenn, Andrew Neil Mabe, Stephen A. Payne
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Patent number: 10647914Abstract: Scintillating plastics resistant to crazing and fogging, methods of making and using the same are disclosed. The scintillating plastics include: one or more primary polymers present in an amount ranging from about 40 wt % to about 95 wt %; one or more secondary polymers present in an amount ranging from about 1 wt % to about 60 wt %; and one or more fluors present in an amount ranging from about 0.1 wt % to about 50 wt %. Methods of making such plastics include: creating a homogenous mixture of precursor materials including primary polymer, secondary polymer, and fluor in the amounts set forth above; and polymerizing the homogenous mixture. Methods of using such plastics include: exposing the scintillating plastic to one or more extreme environmental conditions for a predetermined amount of time without generating crazing or fogging within the scintillating plastic. Various additional features and specific embodiments of these inventive concepts are also disclosed.Type: GrantFiled: March 17, 2017Date of Patent: May 12, 2020Assignee: Lawrence Livermore National Security, LLCInventors: Natalia P. Zaitseva, M. Leslie Carman, Andrew M. Glenn, Andrew Neil Mabe, Stephen A. Payne
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Patent number: 10266761Abstract: In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix comprising at least one of: polyvinyl xylene (PVX); polyvinyl diphenyl; and polyvinyl tetrahydronaphthalene; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %. A total loading of dye in the scintillator material is sufficient to cause the scintillator material to exhibit a pulse-shape discrimination (PSD) figure of merit (FOM) of about at least 2.0.Type: GrantFiled: March 7, 2016Date of Patent: April 23, 2019Assignee: Lawrence Livermore National Security, LLCInventors: Natalia P. Zaitseva, M Leslie Carman, Nerine Cherepy, Andrew M. Glenn, Sebastien Hamel, Stephen A. Payne, Benjamin L. Rupert
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Publication number: 20180265775Abstract: Scintillating plastics resistant to crazing and fogging, methods of making and using the same are disclosed. The scintillating plastics include: one or more primary polymers present in an amount ranging from about 40 wt % to about 95 wt %; one or more secondary polymers present in an amount ranging from about 1 wt % to about 60 wt %; and one or more fluors present in an amount ranging from about 0.1 wt % to about 50 wt %. Methods of making such plastics include: creating a homogenous mixture of precursor materials including primary polymer, secondary polymer, and fluor in the amounts set forth above; and polymerizing the homogenous mixture. Methods of using such plastics include: exposing the scintillating plastic to one or more extreme environmental conditions for a predetermined amount of time without generating crazing or fogging within the scintillating plastic. Various additional features and specific embodiments of these inventive concepts are also disclosed.Type: ApplicationFiled: March 17, 2017Publication date: September 20, 2018Inventors: Natalia P. Zaitseva, M. Leslie Carman, Andrew M. Glenn, Andrew Neil Mabe, Stephen A. Payne
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Patent number: 9650564Abstract: A scintillator material according to one embodiment includes a polymer matrix; a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 3 wt % or more; and at least one component in the polymer matrix, the component being selected from a group consisting of B, Li, Gd, a B-containing compound, a Li-containing compound and a Gd-containing compound, wherein the scintillator material exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays. A system according to one embodiment includes a scintillator material as disclosed herein and a photodetector for detecting the response of the material to fast neutron, thermal neutron and gamma ray irradiation.Type: GrantFiled: May 14, 2012Date of Patent: May 16, 2017Assignee: Lawrence Livermore National Security, LLCInventors: Natalia P. Zaitseva, M. Leslie Carman, Michelle A. Faust, Andrew M. Glenn, H. Paul Martinez, Iwona A. Pawelczak, Stephen A. Payne, Keith E. Lewis
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Publication number: 20160186052Abstract: In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix comprising at least one of: polyvinyl xylene (PVX); polyvinyl diphenyl; and polyvinyl tetrahydronaphthalene; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %. A total loading of dye in the scintillator material is sufficient to cause the scintillator material to exhibit a pulse-shape discrimination (PSD) figure of merit (FOM) of about at least 2.0.Type: ApplicationFiled: March 7, 2016Publication date: June 30, 2016Inventors: Natalia P. Zaitseva, M Leslie Carman, Nerine Cherepy, Andrew M. Glenn, Sebastien Hamel, Stephen A. Payne, Benjamin L. Rupert
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Patent number: 9309456Abstract: In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %.Type: GrantFiled: April 2, 2012Date of Patent: April 12, 2016Assignee: Lawrence Livermore National Security, LLCInventors: Natalia P. Zaitseva, M Leslie Carman, Nerine Cherepy, Andrew M. Glenn, Sebastien Hamel, Stephen A. Payne, Benjamin L. Rupert
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Patent number: 9274237Abstract: In one embodiment, a scintillator includes a scintillator material; a primary fluor, and a Li-containing compound, where the Li-containing compound is soluble in the primary fluor, and where the scintillator exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays.Type: GrantFiled: April 15, 2014Date of Patent: March 1, 2016Assignee: Lawrence Livermore National Security, LLCInventors: Natalia P. Zaitseva, M. Leslie Carman, Michelle A. Faust, Andrew M. Glenn, H. Paul Martinez, Stephen A. Payne
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Publication number: 20150028217Abstract: In one embodiment, a scintillator includes a scintillator material; a primary fluor, and a Li-containing compound, where the Li-containing compound is soluble in the primary fluor, and where the scintillator exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays.Type: ApplicationFiled: April 15, 2014Publication date: January 29, 2015Applicant: Lawrence Livermore National Sercurity, LLCInventors: Natalia P. Zaitseva, M. Leslie Carman, Michelle A. Faust, Andrew M. Glenn, H. Paul Martinez, Stephen A. Payne
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Patent number: 8835865Abstract: A mixed organic crystal according to one embodiment includes a single mixed crystal having two compounds with different bandgap energies, the organic crystal having a physical property of exhibiting a signal response signature for neutrons from a radioactive source, wherein the signal response signature does not include a significantly-delayed luminescence characteristic of neutrons interacting with the organic crystal relative to a luminescence characteristic of gamma rays interacting with the organic crystal. According to one embodiment, an organic crystal includes bibenzyl and stilbene or a stilbene derivative, the organic crystal having a physical property of exhibiting a signal response signature for neutrons from a radioactive source.Type: GrantFiled: November 7, 2012Date of Patent: September 16, 2014Assignee: Lawrence Livermore National Security, LLC.Inventors: Natalia P. Zaitseva, M Leslie Carman, Andrew M. Glenn, Sebastien Hamel, Robert Hatarik, Stephen A. Payne, Wolfgang Stoeffl
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Publication number: 20140027646Abstract: In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %.Type: ApplicationFiled: April 2, 2012Publication date: January 30, 2014Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Natalia P. Zaitseva, M Leslie Carman, Nerine Cherepy, Andrew M. Glenn, Sebastien Hamel, Stephen A. Payne, Benjamin L. Rupert
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Publication number: 20130299702Abstract: A scintillator material according to one embodiment includes a polymer matrix; a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 3 wt % or more; and at least one component in the polymer matrix, the component being selected from a group consisting of B, Li, Gd, a B-containing compound, a Li-containing compound and a Gd-containing compound, wherein the scintillator material exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays. A system according to one embodiment includes a scintillator material as disclosed herein and a photodetector for detecting the response of the material to fast neutron, thermal neutron and gamma ray irradiation.Type: ApplicationFiled: May 14, 2012Publication date: November 14, 2013Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventors: Natalia P. Zaitseva, M Leslie Carman, Michelle A. Faust, Andrew M. Glenn, H. Paul Martinez, Iwona A. Pawelczak, Stephen A. Payne, Keith E. Lewis
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Patent number: D296176Type: GrantFiled: November 27, 1985Date of Patent: June 14, 1988Inventor: Andrew M. Glenn