Patents by Inventor Andrew M. Glenn

Andrew M. Glenn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240165215
    Abstract: The present disclosure relates to immunogenic compositions comprising at least one Yersinia pestis (Y. pestis) antigen, an aluminum salt adjuvant, and an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against Y. pestis in a subject in need thereof. The present disclosure also relates to kits and methods using the immunogenic compositions, or two separate compositions which together comprise the antigen, the aluminum salt adjuvant, and the oligonucleotide.
    Type: Application
    Filed: June 29, 2023
    Publication date: May 23, 2024
    Applicants: Dynavax Technologies Corporation, The Government of the United States, as Represented by the Secretary of the Army
    Inventors: Robert S. JANSSEN, David Novack, Wai Kwan Chung, Andrew M. Glenn, Lucy A. Ward
  • Publication number: 20210317364
    Abstract: A scintillator material includes a polymer matrix, a primary dye in the polymer matrix, the primary dye being a fluorescent dye; a secondary dye, and a Li-containing compound in the polymer matrix, where the Li-containing compound is a Li salt of a short-chain aliphatic acid. In addition, the scintillator material exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons.
    Type: Application
    Filed: April 8, 2021
    Publication date: October 14, 2021
    Inventors: Natalia P. Zaitseva, M Leslie Carman, Andrew M. Glenn, Andrew Neil Mabe
  • Publication number: 20200224087
    Abstract: Scintillating plastics resistant to crazing and fogging, methods of making and using the same are disclosed. The scintillating plastics include: one or more primary polymers present in an amount ranging from about 40 wt % to about 95 wt %; one or more secondary polymers present in an amount ranging from about 1 wt % to about 60 wt %; and one or more fluors present in an amount ranging from about 0.1 wt % to about 50 wt %. Methods of making such plastics include: creating a homogenous mixture of precursor materials including primary polymer, secondary polymer, and fluor in the amounts set forth above; and polymerizing the homogenous mixture. Methods of using such plastics include: exposing the scintillating plastic to one or more extreme environmental conditions for a predetermined amount of time without generating crazing or fogging within the scintillating plastic. Various additional features and specific embodiments of these inventive concepts are also disclosed.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 16, 2020
    Inventors: Natalia P. Zaitseva, M Leslie Carman, Andrew M. Glenn, Andrew Neil Mabe, Stephen A. Payne
  • Patent number: 10647914
    Abstract: Scintillating plastics resistant to crazing and fogging, methods of making and using the same are disclosed. The scintillating plastics include: one or more primary polymers present in an amount ranging from about 40 wt % to about 95 wt %; one or more secondary polymers present in an amount ranging from about 1 wt % to about 60 wt %; and one or more fluors present in an amount ranging from about 0.1 wt % to about 50 wt %. Methods of making such plastics include: creating a homogenous mixture of precursor materials including primary polymer, secondary polymer, and fluor in the amounts set forth above; and polymerizing the homogenous mixture. Methods of using such plastics include: exposing the scintillating plastic to one or more extreme environmental conditions for a predetermined amount of time without generating crazing or fogging within the scintillating plastic. Various additional features and specific embodiments of these inventive concepts are also disclosed.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: May 12, 2020
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Natalia P. Zaitseva, M. Leslie Carman, Andrew M. Glenn, Andrew Neil Mabe, Stephen A. Payne
  • Patent number: 10266761
    Abstract: In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix comprising at least one of: polyvinyl xylene (PVX); polyvinyl diphenyl; and polyvinyl tetrahydronaphthalene; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %. A total loading of dye in the scintillator material is sufficient to cause the scintillator material to exhibit a pulse-shape discrimination (PSD) figure of merit (FOM) of about at least 2.0.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: April 23, 2019
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Natalia P. Zaitseva, M Leslie Carman, Nerine Cherepy, Andrew M. Glenn, Sebastien Hamel, Stephen A. Payne, Benjamin L. Rupert
  • Publication number: 20180265775
    Abstract: Scintillating plastics resistant to crazing and fogging, methods of making and using the same are disclosed. The scintillating plastics include: one or more primary polymers present in an amount ranging from about 40 wt % to about 95 wt %; one or more secondary polymers present in an amount ranging from about 1 wt % to about 60 wt %; and one or more fluors present in an amount ranging from about 0.1 wt % to about 50 wt %. Methods of making such plastics include: creating a homogenous mixture of precursor materials including primary polymer, secondary polymer, and fluor in the amounts set forth above; and polymerizing the homogenous mixture. Methods of using such plastics include: exposing the scintillating plastic to one or more extreme environmental conditions for a predetermined amount of time without generating crazing or fogging within the scintillating plastic. Various additional features and specific embodiments of these inventive concepts are also disclosed.
    Type: Application
    Filed: March 17, 2017
    Publication date: September 20, 2018
    Inventors: Natalia P. Zaitseva, M. Leslie Carman, Andrew M. Glenn, Andrew Neil Mabe, Stephen A. Payne
  • Patent number: 9650564
    Abstract: A scintillator material according to one embodiment includes a polymer matrix; a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 3 wt % or more; and at least one component in the polymer matrix, the component being selected from a group consisting of B, Li, Gd, a B-containing compound, a Li-containing compound and a Gd-containing compound, wherein the scintillator material exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays. A system according to one embodiment includes a scintillator material as disclosed herein and a photodetector for detecting the response of the material to fast neutron, thermal neutron and gamma ray irradiation.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: May 16, 2017
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Natalia P. Zaitseva, M. Leslie Carman, Michelle A. Faust, Andrew M. Glenn, H. Paul Martinez, Iwona A. Pawelczak, Stephen A. Payne, Keith E. Lewis
  • Publication number: 20160186052
    Abstract: In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix comprising at least one of: polyvinyl xylene (PVX); polyvinyl diphenyl; and polyvinyl tetrahydronaphthalene; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %. A total loading of dye in the scintillator material is sufficient to cause the scintillator material to exhibit a pulse-shape discrimination (PSD) figure of merit (FOM) of about at least 2.0.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Inventors: Natalia P. Zaitseva, M Leslie Carman, Nerine Cherepy, Andrew M. Glenn, Sebastien Hamel, Stephen A. Payne, Benjamin L. Rupert
  • Patent number: 9309456
    Abstract: In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: April 12, 2016
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Natalia P. Zaitseva, M Leslie Carman, Nerine Cherepy, Andrew M. Glenn, Sebastien Hamel, Stephen A. Payne, Benjamin L. Rupert
  • Patent number: 9274237
    Abstract: In one embodiment, a scintillator includes a scintillator material; a primary fluor, and a Li-containing compound, where the Li-containing compound is soluble in the primary fluor, and where the scintillator exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: March 1, 2016
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Natalia P. Zaitseva, M. Leslie Carman, Michelle A. Faust, Andrew M. Glenn, H. Paul Martinez, Stephen A. Payne
  • Publication number: 20150028217
    Abstract: In one embodiment, a scintillator includes a scintillator material; a primary fluor, and a Li-containing compound, where the Li-containing compound is soluble in the primary fluor, and where the scintillator exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays.
    Type: Application
    Filed: April 15, 2014
    Publication date: January 29, 2015
    Applicant: Lawrence Livermore National Sercurity, LLC
    Inventors: Natalia P. Zaitseva, M. Leslie Carman, Michelle A. Faust, Andrew M. Glenn, H. Paul Martinez, Stephen A. Payne
  • Patent number: 8835865
    Abstract: A mixed organic crystal according to one embodiment includes a single mixed crystal having two compounds with different bandgap energies, the organic crystal having a physical property of exhibiting a signal response signature for neutrons from a radioactive source, wherein the signal response signature does not include a significantly-delayed luminescence characteristic of neutrons interacting with the organic crystal relative to a luminescence characteristic of gamma rays interacting with the organic crystal. According to one embodiment, an organic crystal includes bibenzyl and stilbene or a stilbene derivative, the organic crystal having a physical property of exhibiting a signal response signature for neutrons from a radioactive source.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: September 16, 2014
    Assignee: Lawrence Livermore National Security, LLC.
    Inventors: Natalia P. Zaitseva, M Leslie Carman, Andrew M. Glenn, Sebastien Hamel, Robert Hatarik, Stephen A. Payne, Wolfgang Stoeffl
  • Publication number: 20140027646
    Abstract: In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %.
    Type: Application
    Filed: April 2, 2012
    Publication date: January 30, 2014
    Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Natalia P. Zaitseva, M Leslie Carman, Nerine Cherepy, Andrew M. Glenn, Sebastien Hamel, Stephen A. Payne, Benjamin L. Rupert
  • Publication number: 20130299702
    Abstract: A scintillator material according to one embodiment includes a polymer matrix; a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 3 wt % or more; and at least one component in the polymer matrix, the component being selected from a group consisting of B, Li, Gd, a B-containing compound, a Li-containing compound and a Gd-containing compound, wherein the scintillator material exhibits an optical response signature for thermal neutrons that is different than an optical response signature for fast neutrons and gamma rays. A system according to one embodiment includes a scintillator material as disclosed herein and a photodetector for detecting the response of the material to fast neutron, thermal neutron and gamma ray irradiation.
    Type: Application
    Filed: May 14, 2012
    Publication date: November 14, 2013
    Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Natalia P. Zaitseva, M Leslie Carman, Michelle A. Faust, Andrew M. Glenn, H. Paul Martinez, Iwona A. Pawelczak, Stephen A. Payne, Keith E. Lewis
  • Patent number: D296176
    Type: Grant
    Filed: November 27, 1985
    Date of Patent: June 14, 1988
    Inventor: Andrew M. Glenn