Patents by Inventor Andrew M. INTLEKOFER

Andrew M. INTLEKOFER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • L-2-hydroxyglutarate and stress induced metabolism
    Patent number: 11788112
    Abstract: The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: October 17, 2023
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Andrew M. Intlekofer, Craig B. Thompson
  • L-2-HYDROXYGLUTARATE AND STRESS INDUCED METABOLISM
    Publication number: 20200032315
    Abstract: The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
    Type: Application
    Filed: June 25, 2019
    Publication date: January 30, 2020
    Inventors: Andrew M. Intlekofer, Craig B. Thompson
  • L-2-hydroxyglutarate and stress induced metabolism
    Patent number: 10450596
    Abstract: The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: October 22, 2019
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Andrew M. Intlekofer, Craig B. Thompson
  • L-2-HYDROXYGLUTARATE AND STRESS INDUCED METABOLISM
    Publication number: 20170175164
    Abstract: The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
    Type: Application
    Filed: March 27, 2015
    Publication date: June 22, 2017
    Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Andrew M. INTLEKOFER, Craig B. THOMPSON