Patents by Inventor Andrew M. L. Chan

Andrew M. L. Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Truncated hepatocyte growth factor variant protein HGF/NK2
    Patent number: 7605127
    Abstract: The present invention relates to a novel truncated form of heptocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: October 20, 2009
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Andrew M. L. Chan, Jeffrey S. Rubin, Donald P. Bottaro, Stuart A. Aaronson, Stephen J. Stahl, Paul T. Wingfield, Vittoria Cioce
  • Truncated hepatocyte growth factor variants
    Publication number: 20030124671
    Abstract: The present invention relates to a novel truncated forms of hepatocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions.
    Type: Application
    Filed: October 30, 2002
    Publication date: July 3, 2003
    Inventors: Andrew M.L. Chan, Jeffrey S. Rubin, Donald P. Bottaro, Stuart A. Aaronson, Stephen J. Stahl, Paul T. Wingfield, Vittoria Cioce
  • DNA encoding truncated hepatocyte growth factor variants
    Patent number: 6566098
    Abstract: The present invention relates to a novel truncated forms of hepatocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 20, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Andrew M. L. Chan, Jeffrey S. Rubin, Donald P. Bottaro, Stuart A. Aaronson
  • DNA encoding plasminogen-like growth factor (PLGF) and related embodiments
    Patent number: 6225088
    Abstract: The present invention relates to a potent mitogenic growth factor called plasminogen-like growth factor (PLGF) isolated from conditioned medium of human lung fibroblasts. The protein has an apparent molecular weight under reducing conditioning of 87 kDa and is structurally related to hepatocyte growth factor (HGF); however unlike HGF, which appears to be specific for hepatic cells, PLGF stimulates a wide spectrum of target cells including melanocytes, endothelial cells and epithelial cells but excludes fibroblast cells. The present invention further relates to recombinant cloned DNA fragments and expression cell systems expressing biologically active PLGF. The availability of purified PLGF as well as immunological and molecular probes should facilitate the study of proliferative disorders in which the factor plays an important role.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: May 1, 2001
    Assignee: The United States of America, as represented by the Department of Health and Human Services
    Inventors: Jeffrey S. Rubin, Andrew M. L. Chan, Stuart A. Aaronson
  • Method of stimulating cell growth with a novel broad spectrum human lung fibroblast-derived mitogen
    Patent number: 5821223
    Abstract: The present invention relates to a potent mitogenic growth factor called plasminogen-like growth factor (PLGF) isolated from conditioned medium of human lung fibroblasts. The protein has an apparent molecular weight under reducing conditions of 87 kDa and is structurally related to hepatocyte growth factor (HGF); however unlike HGF, which was reported to be specific for hepatic cells, PLGF stimulates a wide spectrum of target cells including melanocytes, endothelial cells and epithelial cells but excludes fibroblast cells.The present invention further relates to recombinant cloned DNA fragments and expression cell systems expressing biologically active PLGF. The availability of purified PLGF as well as immunological and molecular probes should facilitate the study of proliferative disorders in which the factor plays an important role.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: October 13, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jeffrey S. Rubin, Andrew M.-L. Chan, Stuart A. Aaronson
  • Hepatic growth factor receptor is the MET proto-oncogene
    Patent number: 5648273
    Abstract: The present invention relates to a complex comprising hepatocyte growth factor (HGF) and met proto-oncogene protein. The present invention also relates to methods for detecting the presence of HGF ligand, met proto-oncogene receptor and methods for isolating either the ligand or receptor or complex comprising both. The present invention further relates to methods of diagnostic proliferative disorders and diseases such as hepatitis or hepatocarcinogenesis by detecting these ligand-receptor pairs.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: July 15, 1997
    Assignee: The United States of America, as represented by the Department of Health and Human Services
    Inventors: Donald P. Bottaro, Jeffery S. Rubin, Donna Faletto, Andrew M.-L. Chan, George F. Vande Woude, Stuart A. Aaronson